AC T04430
XX
ID T04430
XX
DT 17.04.2001 (created); mas.
DT 18.06.2015 (updated); msr.
CO Copyright (C), QIAGEN.
XX
FA LXR-alpha
XX
SY liver X receptor alpha; LXR; LXR A; LXR-A; NR1H3; nuclear orphan receptor LXR-alpha; oxysterol receptor LXR-alpha; oxysterol receptor LXRalpha; RLD1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002739 Nr1h3.
XX
CL C0002; CC (rec); 2.1.2.7.1.
XX
SF forms heterodimers with RXR-alpha [5] [6];
SF for the heterodimer with RXR-alpha, see LXR-alpha:RXR-alpha T05320;
SF AF2 domain is necessary for gene activation in response to oxysterols [4];
SF conflict in protein sequence between EMBL entry #AJ132599 (pos. 399:R) and SWISSPROT entry #Q9Z0Y9 (pos. 399:P);
XX
CP (embryo:) probably weak expression starting at embryonic day 13.5 that increases in abundance up to birth [1]; peritoneal macrophages [7] [1] [7].
EX liver,,,adult; high; Northern blot; total RNA; [5].
EX mouse, Mus musculus,,,Theiler Stage 15; none; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 17; none; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 19; none; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 20; none; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 21; very low; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 22; very low; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 23; low; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 24; medium; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 25; high; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 26; high; Northern blot; mRNA (poly-A); [1].
EX white fat,,,adult; high; Northern blot; total RNA; [5].
XX
FF activator as a heterodimer with RXR-alpha [5] [6];
FF ligands: oxysterols 24(S),25-epoxycholesterol, 24(S)-hydroxycholesterol and 22(R)-hydroxycholesterol [3];
FF seems to link fatty acid and cholesterol metabolism via induction of SREBP-1c gene expression G002466 [5];
FF activates transcription of (rat) cholesterol 7alpha-hydroxylase gene (CYP7A) G001194 in vitro (CYP7A encodes enzyme for initial and rate-limiting step in classical conversion of cholesterol to bile acids) [3];
FF mRNA is indirectly induced by insulin, therefore is an important mediator of insulin effects in liver [8];
XX
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T01345 RXR-alpha; human, Homo sapiens.
XX
MX M00965 V$DR4_Q2.
MX M00647 V$LXR_Q3.
MX M03795 V$LXR_Q6.
MX M07280 V$NR1NR2_Q3.
XX
BS R27494.
BS R68458.
BS R62846.
BS R59922.
BS R59923.
BS R59924.
BS R42105.
BS R40416.
BS R28551.
BS R14416.
BS R09971.
BS R19644.
BS R57619.
XX
DR TRANSPATH: MO000028283.
DR UniProtKB: Q9Z0Y9;
XX
RN [1]; RE0010391.
RX PUBMED: 7744246.
RA Willy P. J., Umesono K., Ong E. S., Evans R. M., Heyman R. A., Mangelsdorf D. J.
RT LXR, a nuclear receptor that defines a distinct retinoid response pathway
RL Genes Dev. 9:1033-1045 (1995).
RN [2]; RE0016052.
RX PUBMED: 7935418.
RA Apfel R., Benbrook D., Lernhardt E., Ortiz M. A., Salbert G., Pfahl M.
RT A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
RL Mol. Cell. Biol. 14:7025-7035 (1994).
RN [3]; RE0016108.
RX PUBMED: 9013544.
RA Lehmann J. M., Kliewer S. A., Moore L. B., Smith-Oliver T. A., Oliver B. B., Su J. L., Sundseth S. S., Winegar D. A., Blanchard D. E., Spencer T. A., Willson T. M.
RT Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
RL J. Biol. Chem. 272:3137-3140 (1997).
RN [4]; RE0016118.
RX PUBMED: 11035776.
RA Venkateswaran A., Laffitte B. A., Joseph S. B., Mak P. A., Wilpitz D. C., Edwards P. A., Tontonoz P.
RT Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
RL Proc. Natl. Acad. Sci. USA 97:12097-12102 (2000).
RN [5]; RE0016121.
RX PUBMED: 11287605.
RA Yoshikawa T., Shimano H., Amemiya-Kudo M., Yahagi N., Hasty A. H., Matsuzaka T., Okazaki H., Tamura Y., Iizuka Y., Ohashi K., Osuga J. I., Harada K., Gotoda T., Kimura S., Ishibashi S., Yamada N.
RT Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
RL Mol. Cell. Biol. 21:2991-3000 (2001).
RN [6]; RE0016208.
RX PUBMED: 11030331.
RA Lu T. T., Makishima M., Repa J. J., Schoonjans K., Kerr T. A., Auwerx J., Mangelsdorf D. J.
RT Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
RL Mol. Cell 6:507-515 (2000).
RN [7]; RE0023359.
RX PUBMED: 10858438.
RA Costet P., Luo Y., Wang N., Tall A. R.
RT Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
RL J. Biol. Chem. 275:28240-28245 (2000).
RN [8]; RE0023594.
RX PUBMED: 11781314.
RA Tobin K. A., Ulven S. M., Schuster G. U., Steineger H. H., Andresen S. M., Gustafsson J. A., Nebb H. I.
RT Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis.
RL J. Biol. Chem. 277:10691-10697 (2002).
RN [9]; RE0064905.
RX PUBMED: 16461908.
RA Majdalawieh A., Zhang L., Fuki I. V., Rader D. J., Ro H. S.
RT Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation.
RL Proc. Natl. Acad. Sci. USA 103:2346-2351 (2006).
XX
//