AC T05320
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ID T05320
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DT 29.10.2002 (created); oke.
DT 13.02.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA LXR-alpha:RXR-alpha
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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CL C0002; CC (rec).
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SF heterodimer, for individual polypeptides see mouse LXR-alpha T04430 and mouse RXR-alpha T01331;
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FF activator upon induction by oxysterols and rexinoids [2] [3] [4] [5];
FF classical binding DNA element is DR4;
FF plays an important role in cholesterol homeostasis [2] [4];
FF regulates cholesterol catabolism into bile acids by induction of CYP7A [2] [4];
FF regulates reverse cholesterol transport by induction of ABCA1 expression in intestine [2];
FF regulates cholesterol efflux in macrophages [1];
FF induces ABC8 transporter [5];
FF regulates glucose metabolism in liver and in adipose tissue [6];
FF in adipose tissue activates transcription of insulin-sensitive glucose transporter GLUT4 gene [6];
FF can act synergistically with LRH-1 (FTF) [4];
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MX M00965 V$DR4_Q2.
MX M00766 V$LXRDR4_Q3.
MX M00647 V$LXR_Q3.
MX M07280 V$NR1NR2_Q3.
MX M00964 V$PXR_Q2.
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BS R14234.
BS R14395.
BS R28002.
BS R28491.
BS R28492.
BS R28493.
BS R28494.
BS R28495.
BS R28496.
BS R28554.
BS R14415.
BS R28589.
BS R28591.
BS R28593.
BS R14402.
BS R14416.
BS R09971.
BS R09972.
BS R09968.
BS R13134.
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DR TRANSPATH: MO000033925.
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RN [1]; RE0016118.
RX PUBMED: 11035776.
RA Venkateswaran A., Laffitte B. A., Joseph S. B., Mak P. A., Wilpitz D. C., Edwards P. A., Tontonoz P.
RT Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
RL Proc. Natl. Acad. Sci. USA 97:12097-12102 (2000).
RN [2]; RE0016119.
RX PUBMED: 10968783.
RA Repa J. J., Turley S. D., Lobaccaro J. A., Medina J., Li L., Lustig K., Shan B., Heyman R. A., Dietschy J. M., Mangelsdorf D. J.
RT Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
RL Science 289:1524-1529 (2000).
RN [3]; RE0016121.
RX PUBMED: 11287605.
RA Yoshikawa T., Shimano H., Amemiya-Kudo M., Yahagi N., Hasty A. H., Matsuzaka T., Okazaki H., Tamura Y., Iizuka Y., Ohashi K., Osuga J. I., Harada K., Gotoda T., Kimura S., Ishibashi S., Yamada N.
RT Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
RL Mol. Cell. Biol. 21:2991-3000 (2001).
RN [4]; RE0016208.
RX PUBMED: 11030331.
RA Lu T. T., Makishima M., Repa J. J., Schoonjans K., Kerr T. A., Auwerx J., Mangelsdorf D. J.
RT Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
RL Mol. Cell 6:507-515 (2000).
RN [5]; RE0023589.
RX PUBMED: 10799558.
RA Venkateswaran A., Repa J. J., Lobaccaro J. M., Bronson A., Mangelsdorf D. J., Edwards P. A.
RT Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.
RL J. Biol. Chem. 275:14700-14707 (2000).
RN [6]; RE0023611.
RX PUBMED: 12697904.
RA Laffitte B. A., Chao L. C., Li J., Walczak R., Hummasti S., Joseph S. B., Castrillo A., Wilpitz D. C., Mangelsdorf D. J., Collins J. L., Saez E., Tontonoz P.
RT Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
RL Proc. Natl. Acad. Sci. USA 100:5419-5424 (2003).
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