AC T02753
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ID T02753
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DT 04.06.1999 (created); mpr.
DT 25.09.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA FXR
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SY BAR; bile acid receptor; farnesoid X activated receptor; FXR; HRR-1; HRR1; NR1H4; retinoid X receptor interacting protein 14; RIP-14; RIP14.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004841 Nr1h4.
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CL C0002; CC (rec); 2.1.2.7.3.
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SF forms heterodimers with RXR-alpha, see mouse FXR:RXR-alpha T05322;
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CP (adult:) adrenal cortex [3].
EX adrenal gland (right + left),,,adult; high; RT-PCR; RNA (undefined); [6].
EX bone marrow,,,adult; none; RT-PCR; RNA (undefined); [6].
EX brain,,,embryo; none; RT-PCR; RNA (undefined); [6].
EX eye and related structures (right and left),,,adult; very low; RT-PCR; RNA (undefined); [6].
EX heart,,,adult; high; RT-PCR; RNA (undefined); [6].
EX heart,,,embryo; low; RT-PCR; RNA (undefined); [6].
EX intestine,,,adult; high; RT-PCR; RNA (undefined); [6].
EX intestine,,,embryo; high; RT-PCR; RNA (undefined); [6].
EX kidney (right and left),,,adult; very high; RT-PCR; RNA (undefined); [6].
EX kidney (right and left),,,embryo; low; RT-PCR; RNA (undefined); [6].
EX liver,,,adult; very high; RT-PCR; RNA (undefined); [6].
EX liver,,,embryo; medium; RT-PCR; RNA (undefined); [6].
EX lung,,,adult; none; RT-PCR; RNA (undefined); [6].
EX lung,,,embryo; very low; RT-PCR; RNA (undefined); [6].
EX mouse, Mus musculus,,,Theiler Stage 11; medium; RT-PCR; RNA (undefined); [6].
EX mouse, Mus musculus,,,Theiler Stage 22; medium; RT-PCR; RNA (undefined); [6].
EX ovary,,,adult; medium; RT-PCR; RNA (undefined); [6].
EX ovary,,,embryo; medium; RT-PCR; RNA (undefined); [6].
EX skin,,,adult; none; RT-PCR; RNA (undefined); [6].
EX skin,,,embryo; none; RT-PCR; RNA (undefined); [6].
EX spleen,,,adult; high; RT-PCR; RNA (undefined); [6].
EX testis (right and left),,,adult; very low; RT-PCR; RNA (undefined); [6].
EX testis (right and left),,,embryo; medium; RT-PCR; RNA (undefined); [6].
EX thymus,,,adult; high; RT-PCR; RNA (undefined); [6].
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FF activator as a heterodimer with RXR-alpha [4];
FF natural activating ligands: bile acids, the most potent are CDCA, DCA [5];
FF regulates lipid metabolism [4];
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IN T01331 RXR-alpha; mouse, Mus musculus.
IN T01345 RXR-alpha; human, Homo sapiens.
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MX M07256 V$FXRRXR_Q5.
MX M01268 V$FXR_Q2.
MX M00631 V$FXR_Q3.
MX M03790 V$FXR_Q5.
MX M03795 V$LXR_Q6.
MX M00964 V$PXR_Q2.
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BS R62676.
BS R56851.
BS R59825.
BS R63959.
BS R63961.
BS R64039.
BS R63944.
BS R63975.
BS R63967.
BS R63969.
BS R62225.
BS R62230.
BS R63979.
BS R63977.
BS R63965.
BS R63957.
BS R59835.
BS R59840.
BS R66004.
BS R10074.
BS R63949.
BS R72453.
BS R72455.
BS R63985.
BS R62632.
BS R67225.
BS R69799.
BS R69800.
BS R69801.
BS R63954.
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DR TRANSPATH: MO000026727.
DR UniProtKB: Q60641;
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RN [1]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [2]; RE0013645.
RX PUBMED: 7760852.
RA Seol W., Choi H. S., Moore D. D.
RT Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors
RL Mol. Endocrinol. 9:72-85 (1995).
RN [3]; RE0016189.
RX PUBMED: 7774010.
RA Forman B. M., Goode E., Chen J., Oro A. E., Bradley D. J., Perlmann T., Noonan D. J., Burka L. T., McMorris T., Lamph W. W., et a. l.
RT Identification of a nuclear receptor that is activated by farnesol metabolites
RL Cell 81:687-693 (1995).
RN [4]; RE0018126.
RX PUBMED: 10998425.
RA Urizar N. L., Dowhan D. H., Moore D. D.
RT The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression.
RL J. Biol. Chem. 275:39313-39317 (2000).
RN [5]; RE0023349.
RX PUBMED: 10334992.
RA Makishima M., Okamoto A. Y., Repa J. J., Tu H., Learned R. M., Luk A., Hull M. V., Lustig K. D., Mangelsdorf D. J., Shan B.
RT Identification of a nuclear receptor for bile acids.
RL Science 284:1362-1365 (1999).
RN [6]; RE0023352.
RX PUBMED: 12529392.
RA Otte K., Kranz H., Kober I., Thompson P., Hoefer M., Haubold B., Remmel B., Voss H., Kaiser C., Albers M., Cheruvallath Z., Jackson D., Casari G., Koegl M., Paabo S., Mous J., Kremoser C., Deuschle U.
RT Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.
RL Mol. Cell. Biol. 23:864-872 (2003).
XX
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