AC T01351
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ID T01351
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DT 26.10.1994 (created); ewi.
DT 25.02.2014 (updated); asv.
CO Copyright (C), QIAGEN.
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FA T3R-alpha
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SY c-ErbA; c-ErbA-alpha; NR1A1; T3R; T3R-alpha; THRA; thyroid hormone receptor; thyroid hormone receptor alpha; TR; TRalpha.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G031448 THRA.
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CL C0002; CC (rec); 2.1.2.2.1.
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CP cardiac and skeletal muscle [8].
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FF may play a role in both immature and mature neural cells (brain) [1];
FF activates the myoD gene during muscle differentiation via binding to a T3 responsive element as a heterodimeric complex together with RXR-alpha or RXR-gamma [8];
FF binding to DNA as homodimer or heterodimer with RXR-alpha (to a direct repeat with an intervening spacer of 4 bp) and transcriptional activity is critically dependent on sequence between the two half-sites [9];
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IN T34290 Alien; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T01327 NR1B1; mouse, Mus musculus.
IN T01356 NR1B1; clawed frog, Xenopus laevis.
IN T00720 RAR-gamma; human, Homo sapiens.
IN T00716 RAR; monkey, Cercopithecus aethiops.
IN T00717 RAR; mouse, Mus musculus.
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01333 RXR-gamma; mouse, Mus musculus.
IN T01351 T3R-alpha; chick, Gallus gallus.
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MX M01724 V$T3RALPHA_Q6.
MX M00963 V$T3R_Q6.
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BS R04759.
BS R02595.
BS R26837.
BS R26838.
BS R00619.
BS R01690.
BS R03523.
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DR TRANSPATH: MO000025607.
DR TRANSCOMPEL: C00361.
DR UniProtKB: P04625;
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RN [1]; RE0000466.
RX PUBMED: 1991448.
RA Forrest D., Hallboeoek F., Persson H., Vennstroem B.
RT Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes
RL EMBO J. 10:269-275 (1991).
RN [2]; RE0001498.
RX PUBMED: 1922030.
RA Lazar M. A., Berrodin T. J., Harding H. P.
RT Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor
RL Mol. Cell. Biol. 11:5005-5015 (1991).
RN [3]; RE0001739.
RX PUBMED: 1656224.
RA Lucas P. C., Forman B. M., Samuels H. H., Granner D. K.
RT Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding
RL Mol. Cell. Biol. 11:5164-5170 (1991).
RN [4]; RE0001752.
RX PUBMED: 2172797.
RA Forman B. M., Samuels H. H.
RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
RL Mol. Endocrinol. 4:1293-1301 (1990).
RN [5]; RE0001828.
RX PUBMED: 2879242.
RA Sap J., Munoz A., Damm K., Goldberg Y., Ghysdael J., Leutz A., Beug H., Vennstroem B.
RT The c-erb-A protein is a high-affinity receptor for thyroid hormone
RL Nature 324:635-640 (1986).
RN [6]; RE0001853.
RX PUBMED: 2569164.
RA Sap J., Munoz A., Schmitt J., Stunnenberg H., Vennstroem B.
RT Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product
RL Nature 340:242 (1989).
RN [7]; RE0002738.
RX PUBMED: 2159385.
RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R.
RT Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site
RL Cell 61:505-514 (1990).
RN [8]; RE0003240.
RX PUBMED: 8127707.
RA Muscat G. E. O., Mynett-Johnson L., Dowhan D., Downes M., Griggs R.
RT Activation of MyoD gene transcription by 3, 4, 3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors
RL Nucleic Acids Res. 22:583-591 (1994).
RN [9]; RE0017093.
RX PUBMED: 8710493.
RA Harbers M., Wahlstrom G. M., Vennstrom B.
RT Transactivation by the thyroid hormone receptor is dependent on the spacer sequence in hormone response elements containing directly repeated half-sites
RL Nucleic Acids Res. 24:2252-2259 (1996).
RN [10]; RE0034472.
RX PUBMED: 10877839.
RA Polly P., Herdick M., Moehren U., Baniahmad A., Heinzel T., Carlberg C.
RT VDR-Alien: a novel, DNA-selective vitamin D(3) receptor-corepressor partnership.
RL FASEB J. 14:1455-63 (2000).
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