TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01351 XX ID T01351 XX DT 26.10.1994 (created); ewi. DT 25.02.2014 (updated); asv. CO Copyright (C), QIAGEN. XX FA T3R-alpha XX SY c-ErbA; c-ErbA-alpha; NR1A1; T3R; T3R-alpha; THRA; thyroid hormone receptor; thyroid hormone receptor alpha; TR; TRalpha. XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae XX GE G031448 THRA. XX CL C0002; CC (rec); XX CP cardiac and skeletal muscle [8]. XX FF may play a role in both immature and mature neural cells (brain) [1]; FF activates the myoD gene during muscle differentiation via binding to a T3 responsive element as a heterodimeric complex together with RXR-alpha or RXR-gamma [8]; FF binding to DNA as homodimer or heterodimer with RXR-alpha (to a direct repeat with an intervening spacer of 4 bp) and transcriptional activity is critically dependent on sequence between the two half-sites [9]; XX IN T34290 Alien; human, Homo sapiens. IN T00719 NR1B1-isoform1; human, Homo sapiens. IN T01327 NR1B1; mouse, Mus musculus. IN T01356 NR1B1; clawed frog, Xenopus laevis. IN T00720 RAR-gamma; human, Homo sapiens. IN T00716 RAR; monkey, Cercopithecus aethiops. IN T00717 RAR; mouse, Mus musculus. IN T01331 RXR-alpha; mouse, Mus musculus. IN T01345 RXR-alpha; human, Homo sapiens. IN T01333 RXR-gamma; mouse, Mus musculus. IN T01351 T3R-alpha; chick, Gallus gallus. XX MX M01724 V$T3RALPHA_Q6. MX M00963 V$T3R_Q6. XX BS R04759. BS R02595. BS R26837. BS R26838. BS R00619. BS R01690. BS R03523. XX DR TRANSPATH: MO000025607. DR TRANSCOMPEL: C00361. DR UniProtKB: P04625; XX RN [1]; RE0000466. RX PUBMED: 1991448. RA Forrest D., Hallboeoek F., Persson H., Vennstroem B. RT Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes RL EMBO J. 10:269-275 (1991). RN [2]; RE0001498. RX PUBMED: 1922030. RA Lazar M. A., Berrodin T. J., Harding H. P. RT Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor RL Mol. Cell. Biol. 11:5005-5015 (1991). RN [3]; RE0001739. RX PUBMED: 1656224. RA Lucas P. C., Forman B. M., Samuels H. H., Granner D. K. RT Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding RL Mol. Cell. Biol. 11:5164-5170 (1991). RN [4]; RE0001752. RX PUBMED: 2172797. RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [5]; RE0001828. RX PUBMED: 2879242. RA Sap J., Munoz A., Damm K., Goldberg Y., Ghysdael J., Leutz A., Beug H., Vennstroem B. RT The c-erb-A protein is a high-affinity receptor for thyroid hormone RL Nature 324:635-640 (1986). RN [6]; RE0001853. RX PUBMED: 2569164. RA Sap J., Munoz A., Schmitt J., Stunnenberg H., Vennstroem B. RT Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product RL Nature 340:242 (1989). RN [7]; RE0002738. RX PUBMED: 2159385. RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site RL Cell 61:505-514 (1990). RN [8]; RE0003240. RX PUBMED: 8127707. RA Muscat G. E. O., Mynett-Johnson L., Dowhan D., Downes M., Griggs R. RT Activation of MyoD gene transcription by 3, 4, 3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors RL Nucleic Acids Res. 22:583-591 (1994). RN [9]; RE0017093. RX PUBMED: 8710493. RA Harbers M., Wahlstrom G. M., Vennstrom B. RT Transactivation by the thyroid hormone receptor is dependent on the spacer sequence in hormone response elements containing directly repeated half-sites RL Nucleic Acids Res. 24:2252-2259 (1996). RN [10]; RE0034472. RX PUBMED: 10877839. RA Polly P., Herdick M., Moehren U., Baniahmad A., Heinzel T., Carlberg C. RT VDR-Alien: a novel, DNA-selective vitamin D(3) receptor-corepressor partnership. RL FASEB J. 14:1455-63 (2000). XX //