AC T01648
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ID T01648
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DT 01.02.1996 (created); ewi.
DT 07.08.2013 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA HES-1
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SY hairy and enhancer of split 1 (Drosophila); Hes1; RHL.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014485 Hes1.
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HO Hairy, E(spl) proteins.
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CL C0010; bHLH; 1.2.4.1.1.
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SF 77% homology with Hairy within the bHLH domain [1];
SF preferentially binding to N-box (CACNAG), but also (weakly) to E-box (CANNTG) [1];
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CP widespread; high levels in embryos and adults: gastrointestinal tract; high in embryos, low in adults: heart, kidney, muscle [1].
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FF E2 (beta-estradiol) mediated suppression is counteracted by TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) in T47D cells [3];
FF repressor;
FF suppresses activation by MyoD or MASH-1, and also myogenic conversion by MyoD, probably by sequestering the E47/E12 component [1];
FF immediate-early response gene product to bFGF, EGF, NGF [2];
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IN T02266 AML3-isoform2; mouse, Mus musculus.
IN T02441 AML3; rat, Rattus norvegicus.
IN T08443 AML3; mouse, Mus musculus.
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MX M01009 V$HES1_Q2.
MX M07042 V$HES1_Q3.
MX M07420 V$HES1_Q4.
MX M02011 V$HES1_Q6.
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BS R57318.
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DR TRANSPATH: MO000025835.
DR UniProtKB: Q04666;
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RN [1]; RE0003677.
RX PUBMED: 1340473.
RA Sasai Y., Kageyama R., Tagawa Y., Shigemoto R., Nakanishi S.
RT Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
RL Genes Dev. 6:2620-2634 (1992).
RN [2]; RE0003678.
RX PUBMED: 8417318.
RA Feder J. N., Jan L. Y., Jan Y.-N.
RT A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation
RL Mol. Cell. Biol. 13:105-113 (1993).
RN [3]; RE0031437.
RX PUBMED: 14722248.
RA Thomsen J. S., Kietz S., Strom A., Gustafsson J. A.
RT HES-1, a novel target gene for the aryl hydrocarbon receptor.
RL Mol. Pharmacol. 65:165-71 (2004).
RN [4]; RE0048867.
RX PUBMED: 16195230.
RA Shen Q., Christakos S.
RT The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin.
RL J. Biol. Chem. 280:40589-40598 (2005).
RN [5]; RE0048954.
RX PUBMED: 16753023.
RA Lee J. S., Thomas D. M., Gutierrez G., Carty S. A., Yanagawa S., Hinds P. W.
RT HES1 cooperates with pRb to activate RUNX2-dependent transcription.
RL J. Bone Miner. Res. 21:921-933 (2006).
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