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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T01648 XX ID T01648 XX DT 01.02.1996 (created); ewi. DT 07.08.2013 (updated); jmh. CO Copyright (C), QIAGEN. XX FA HES-1 XX SY hairy and enhancer of split 1 (Drosophila); Hes1; RHL. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014485 Hes1. XX HO Hairy, E(spl) proteins. XX CL C0010; bHLH; 1.2.4.1.1. XX SF 77% homology with Hairy within the bHLH domain [1]; SF preferentially binding to N-box (CACNAG), but also (weakly) to E-box (CANNTG) [1]; XX CP widespread; high levels in embryos and adults: gastrointestinal tract; high in embryos, low in adults: heart, kidney, muscle [1]. XX FF E2 (beta-estradiol) mediated suppression is counteracted by TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) in T47D cells [3]; FF repressor; FF suppresses activation by MyoD or MASH-1, and also myogenic conversion by MyoD, probably by sequestering the E47/E12 component [1]; FF immediate-early response gene product to bFGF, EGF, NGF [2]; XX IN T02266 AML3-isoform2; mouse, Mus musculus. IN T02441 AML3; rat, Rattus norvegicus. IN T08443 AML3; mouse, Mus musculus. XX MX M01009 V$HES1_Q2. MX M07042 V$HES1_Q3. MX M07420 V$HES1_Q4. MX M02011 V$HES1_Q6. XX BS R57318. XX DR TRANSPATH: MO000025835. DR UniProtKB: Q04666; XX RN [1]; RE0003677. RX PUBMED: 1340473. RA Sasai Y., Kageyama R., Tagawa Y., Shigemoto R., Nakanishi S. RT Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split RL Genes Dev. 6:2620-2634 (1992). RN [2]; RE0003678. RX PUBMED: 8417318. RA Feder J. N., Jan L. Y., Jan Y.-N. RT A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation RL Mol. Cell. Biol. 13:105-113 (1993). RN [3]; RE0031437. RX PUBMED: 14722248. RA Thomsen J. S., Kietz S., Strom A., Gustafsson J. A. RT HES-1, a novel target gene for the aryl hydrocarbon receptor. RL Mol. Pharmacol. 65:165-71 (2004). RN [4]; RE0048867. RX PUBMED: 16195230. RA Shen Q., Christakos S. RT The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin. RL J. Biol. Chem. 280:40589-40598 (2005). RN [5]; RE0048954. RX PUBMED: 16753023. RA Lee J. S., Thomas D. M., Gutierrez G., Carty S. A., Yanagawa S., Hinds P. W. RT HES1 cooperates with pRb to activate RUNX2-dependent transcription. RL J. Bone Miner. Res. 21:921-933 (2006). XX //