AC T00423
XX
ID T00423
XX
DT 15.10.1992 (created); ewi.
DT 01.06.2016 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA IRF-1
XX
SY IRF1; Interferon regulatory factor 1; IRF-1; IRF1; ISGF2.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G000324 IRF1; HGNC: IRF1.
XX
CL C0022; trp; 3.5.3.0.1.
XX
SF M-form appears as 56-kDa protein;
SF IAD2 domain is conserved between IRF-1 and IRF-2, but is different in other family members [18];
SF IAD2 is responsible for protein-protein interactions [18];
XX
FF positive regulator of interferon-beta and IFN-induced genes [10];
FF tumor suppressor antagonizing IRF-2 transforming potential [14];
FF deleted in some leukemias and myelodysplasias showing cytogenetic abnormalities of chromosome 5 [16];
FF M- and G-forms of ISGF2 are generated by posttranscriptional modifications;
FF same DNA binding specificity as IRF-2;
FF inducible by IL-6 [8];
FF inducible by IFN-gamma (and weakly by IFN-alpha) through an inverted GAAANN repeat, no autoregulation observed [11];
FF activated by ISGF3 and thus being a target gene of STAT1 [12] [17];
FF induction requires de novo protein synthesis;
FF cooperates with STAT-1alpha for IFN-gamma-dependent gene induction in myeloid cells [20];
XX
IN T10390 FKLF-isoform1; human, Homo sapiens.
IN T04759 STAT1; human, Homo sapiens.
XX
MX M00062 V$IRF1_01.
MX M04788 V$IRF1_03.
MX M07216 V$IRF1_05.
MX M07045 V$IRF1_Q5.
MX M00747 V$IRF1_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
XX
BS R26855.
BS R26958.
BS R26960.
BS R04222.
BS R26786.
BS R26813.
BS R03274.
BS R35884.
BS R19521.
BS R73492.
BS R30511.
BS R59351.
BS R22214.
BS R37713.
BS R34156.
BS R19544.
BS R56000.
BS R25556.
BS R14432.
BS R59336.
BS R59337.
BS R59340.
BS R62772.
BS R35220.
BS R35221.
BS R13380.
BS R26496.
BS R40393.
BS R68433.
BS R13560.
BS R20291.
BS R58818.
BS R26854.
BS R57700.
BS R02897.
BS R14776.
BS R56783.
BS R14801.
BS R26274.
BS R25968.
BS R14433.
BS R14435.
BS R30079.
BS R26722.
BS R30651.
BS R30654.
BS R30648.
BS R30649.
BS R26805.
BS R26810.
BS R26812.
BS R26823.
BS R59987.
BS R26294.
BS R58177.
BS R35243.
BS R26765.
BS R19557.
BS R19558.
BS R00946.
BS R00947.
BS R14802.
BS R26723.
BS R35238.
BS R26398.
BS R68651.
BS R56142.
BS R12726.
BS R26915.
BS R28294.
BS R27050.
BS R19611.
BS R23922.
BS R63550.
BS R68933.
BS R68938.
BS R26784.
BS R26785.
BS R19746.
BS R27105.
BS R39524.
BS R42106.
BS R60954.
BS R34351.
BS R29808.
BS R26477.
BS R27117.
BS R20267.
BS R35882.
BS R13011.
BS R26796.
BS R30991.
BS R22184.
BS R26759.
BS R04683.
BS R02187.
BS R74075.
BS R35587.
BS R01061.
BS R05075.
XX
DR TRANSPATH: MO000007686.
DR TRANSCOMPEL: C00249.
DR TRANSCOMPEL: C00300.
DR TRANSCOMPEL: C00340.
DR TRANSCOMPEL: C00386.
DR UniProtKB: P10914;
XX
RN [1]; RE0000099.
RX PUBMED: 3409321.
RA Miyamoto M., Fujita T., Kimura Y., Maruyama M., Harada H., Sudo Y., Miyata T., Taniguchi T.
RT Regulated Expression of a Gene Encoding a Nuclear Factor, IRF-1, That Specifically Binds to IFN-beta Gene Regulatory Elements
RL Cell 54:903-913 (1988).
RN [2]; RE0000687.
RX PUBMED: 1851123.
RA Keller A. D., Maniatis T.
RT Identification and characterization of a novel repressor of beta-interferon gene expression
RL Genes Dev. 5:868-879 (1991).
RN [3]; RE0001377.
RX PUBMED: 2796995.
RA Pine R., Darnell J. E.
RT In Vivo Evidence of Interaction between Interferon-Stimulated Gene Factors and the Interferon-Stimulated Response Element
RL Mol. Cell. Biol. 9:3533-3537 (1989).
RN [4]; RE0001438.
RX PUBMED: 2342456.
RA Pine R., Decker T., Kessler D. S., Levy D. E., Darnell J. E.
RT Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator of Either
RL Mol. Cell. Biol. 10:2448-2457 (1990).
RN [5]; RE0002006.
RX PUBMED: 2726484.
RA Reich N. C., Darnell jr J. E.
RT Differential binding of interferon-induced factors to an oligonucleotide that mediates transcriptional activation
RL Nucleic Acids Res. 17:3415-3424 (1989).
RN [6]; RE0002092.
RX PUBMED: 2123539.
RA Imam A. M. A., Ackrill A. M., Dale T. C., Kerr I. M., Stark G. R.
RT Transcription factors induced by interferons alpha and gamma
RL Nucleic Acids Res. 18:6573-6580 (1990).
RN [7]; RE0002322.
RX PUBMED: 2460869.
RA Kessler D. S., Levy D. E., Darnell jr J. E.
RT Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes
RL Proc. Natl. Acad. Sci. USA 85:8521-8525 (1988).
RN [8]; RE0002927.
RX PUBMED: 8168491.
RA Harroch S., Revel M., Chebath J.
RT Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA
RL EMBO J. 13:1942-1949 (1994).
RN [9]; RE0002930.
RX PUBMED: 7687740.
RA Tanaka N., Kawakami T., Taniguchi T.
RT Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system
RL Mol. Cell. Biol. 13:4531-4538 (1993).
RN [10]; RE0003466.
RX PUBMED: 1371248.
RA Reis L. F. L., Harada H., Wolchok J. D., Taniguchi T., Vilcek J.
RT Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes
RL EMBO J. 11:185-193 (1992).
RN [11]; RE0003467.
RX PUBMED: 7678055.
RA Sims S. H., Cha Y., Romine M. F., Gao P., Gottlieb K., Deisseroth A. B.
RT A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter
RL Mol. Cell. Biol. 13:690-702 (1993).
RN [12]; RE0003468.
RX PUBMED: 8306959.
RA Pine R., Canova A., Schindler C.
RT Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFNalpha and IFNgamma, and is likely to autoregulate the p91 gene
RL EMBO J. 13:158-167 (1994).
RN [13]; RE0003469.
RX PUBMED: 8197182.
RA Bovolenta C., Driggers P. H., Marks M. S., Medin J. A., Politis A. D., Vogel S. N., Levy D. E., Sakaguchi K., Appella E., Coligan J. E., Ozato K.
RT Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family
RL Proc. Natl. Acad. Sci. USA 91:5046-5050 (1994).
RN [14]; RE0003470.
RX PUBMED: 8438157.
RA Harada H., Kitagawa M., Tanaka N., Yamamoto H., Harada K., Ishihara M., Taniguchi T.
RT Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2
RL Science 259:971-974 (1993).
RN [15]; RE0003471.
RX PUBMED: 2726461.
RA Maruyama M., Fujita T., Taniguchi T.
RT Sequence of a cDNA coding for human IRF-1
RL Nucleic Acids Res. 17:3292-3292 (1989).
RN [16]; RE0003472.
RX PUBMED: 8438156.
RA Willman C. L., Sever C., Pallavicini M. G., Harada H., Tanaka N., Slovak M. L., Yamamoto H., Harada K., Meeker T. C., List A. F., Taniguchi T.
RT Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia
RL Science 259:968-971 (1993).
RN [17]; RE0003473.
RX PUBMED: 7507207.
RA Harada H., Takahashi E.-I., Itoh S., Harada K., Hori T.-A., Taniguchi T.
RT Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system
RL Mol. Cell. Biol. 14:1500-1509 (1994).
RN [18]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [19]; RE0019561.
RX PUBMED: 1382447.
RA CHA Y., SIMS S.H., ROMINE M.F., KAUFMANN M., DEISSEROTH A.B.
RT Human interferon regulatory factor 1: intron-exon organization.
RL DNA Cell Biol. 11:605-611 (1992).
RN [20]; RE0023149.
RX PUBMED: 11781315.
RA Kumatori A., Yang D., Suzuki S., Nakamura M.
RT Cooperation of STAT-1 and IRF-1 in interferon-gamma-induced transcription of the gp91(phox) gene.
RL J. Biol. Chem. 277:9103-9111 (2002).
RN [21]; RE0052693.
RX PUBMED: 17371985.
RA Reardon C., McKay D. M.
RT TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages.
RL J. Immunol. 178:4284-4295 (2007).
RN [22]; RE0063965.
RX PUBMED: 18694960.
RA Moschonas A., Kouraki M., Knox P. G., Thymiakou E., Kardassis D., Eliopoulos A. G.
RT CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1.
RL Mol. Cell. Biol. 28:6208-6222 (2008).
RN [23]; RE0064683.
RX PUBMED: 17947510.
RA Tliba O., Damera G., Banerjee A., Gu S., Baidouri H., Keslacy S., Amrani Y.
RT Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1.
RL Am. J. Respir. Cell Mol. Biol. 38:463-472 (2008).
RN [24]; RE0065158.
RX PUBMED: 18281489.
RA Wang Y., Liu D., Chen P., Koeffler H. P., Tong X., Xie D.
RT Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers.
RL Cancer Res. 68:1136-1143 (2008).
RN [25]; RE0065187.
RX PUBMED: 17237409.
RA Choi J. C., Holtz R., Petroff M. G., Alfaidy N., Murphy S. P.
RT Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway.
RL J. Immunol. 178:1598-1607 (2007).
RN [26]; RE0066609.
RX PUBMED: 17062732.
RA Vlasakova J., Novakova Z., Rossmeislova L., Kahle M., Hozak P., Hodny Z.
RT Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein.
RL Blood 109:1373-1380 (2007).
RN [27]; RE0066678.
RX PUBMED: 10102295.
RA Li W., Nagineni C. N., Hooks J. J., Chepelinsky A. B., Egwuagu C. E.
RT Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors.
RL Invest. Ophthalmol. Vis. Sci. 40:976-982 (1999).
RN [28]; RE0068468.
RX PUBMED: 20525893.
RA Antonios D., Rousseau P., Larange A., Kerdine-Romer S., Pallardy M.
RT Mechanisms of IL-12 synthesis by human dendritic cells treated with the chemical sensitizer NiSO4.
RL J. Immunol. 185:89-98 (2010).
RN [29]; RE0070654.
RX PUBMED: 21336305.
RA Liu F., Wu S., Ren H., Gu J.
RT Klotho suppresses RIG-I-mediated senescence-associated inflammation.
RL Nat. Cell Biol. 13:254-262 (2011).
XX
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