AC T03238
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ID T03238
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DT 11.04.2000 (created); sth.
DT 30.10.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA DDB1
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SY damage-specific DNA binding protein 1; damage-specific DNA binding protein 1, 127kDa; DDB1; DDBA; UV-DDB1; XAP1; XPCE; XPE-BF.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005980 DDB1; HGNC: DDB1.
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SF Human damage-specific DNA binding protein DDBa p127 subunit [1];
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CP tissue- epidermal, fetal lung [1].
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FF DNA repair [1];
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IN T05963 CA150; human, Homo sapiens.
IN T08505 COUP-TF1; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T10210 Evi-1; human, Homo sapiens.
IN T34283 histone H2A{ub}; human, Homo sapiens.
IN T10349 RORalpha; Mammalia.
IN T32323 Sall2; Mammalia.
IN T16013 SIAHBP1; human, Homo sapiens.
IN T04759 STAT1; human, Homo sapiens.
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DR TRANSPATH: MO000027184.
DR UniProtKB: Q16531; DDB1_HUMAN.
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RN [1]; RE0014385.
RX PUBMED: 8530102.
RA Dualan R., Brody T., Keeney S., Nichols A. F., Admon A., Linn S.
RT Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein
RL Genomics 29:62-69 (1995).
RN [2]; RE0051098.
RX PUBMED: 16537899.
RA Bondar T., Kalinina A., Khair L., Kopanja D., Nag A., Bagchi S., Raychaudhuri P.
RT Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome.
RL Mol. Cell. Biol. 26:2531-2539 (2006).
RN [3]; RE0063245.
RX PUBMED: 16473935.
RA Kapetanaki M. G., Guerrero-Santoro J., Bisi D. C., Hsieh C. L., Rapic-Otrin V., Levine A. S.
RT The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.
RL Proc. Natl. Acad. Sci. USA 103:2588-2593 (2006).
RN [4]; RE0067359.
RX PUBMED: 20395298.
RA Lv X. B., Xie F., Hu K., Wu Y., Cao L. L., Han X., Sang Y., Zeng Y. X., Kang T.
RT Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1.
RL J. Biol. Chem. 285:18234-18240 (2010).
RN [5]; RE0071835.
RX PUBMED: 18332868.
RA Huang J., Chen J.
RT VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.
RL Oncogene 27:4056-4064 (2008).
RN [6]; RE0074383.
RX PUBMED: 19112178.
RA Zhang L. J., Liu X., Gafken P. R., Kioussi C., Leid M.
RT A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8).
RL J. Biol. Chem. 284:6156-6168 (2009).
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