AC T09118
XX
ID T09118
XX
DT 26.07.2006 (created); jag.
DT 06.06.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA Sp1-isoform1
XX
SY Sp1; Stimulating Protein 1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G004918 Sp1.
XX
CL C0001; CH.
XX
SZ 784 AA; 80.7 kDa (cDNA) (calc.), 95/105 kDa (SDS)
XX
SQ MSDQDHSMDEVTAVVKIEKDVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQP
SQ SPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATP
SQ TSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQ
SQ FQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIIPNEGSGGNIIAAMPNLLQQAVPL
SQ QGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESSSQP
SQ VTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTPQR
SQ VGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAA
SQ PLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQ
SQ AQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALG
SQ TSGIQVHQLPGLPLAIANTPGDHGTQLGLHGSGGDGIHDETAGGEGENSSDLQPQAGRRT
SQ RREACTCPYCKDSEGRASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCN
SQ WSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVAL
SQ SVGTLPLDSGAGSEGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINIS
SQ GNGF
XX
SC translated from EMBL #AF022363
XX
FT 231 681 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 627 651 
PF00096; zf-C2H2.
FT 627 651 
SM00355; c2h2final6.
FT 627 656 
PS50157; ZINC_FINGER_C2H2_2.
FT 657 681 
PF00096; zf-C2H2.
FT 657 681 
SM00355; c2h2final6.
FT 657 686 
PS50157; ZINC_FINGER_C2H2_2.
FT 687 709 
PF00096; zf-C2H2.
FT 687 709 
SM00355; c2h2final6.
FT 687 714 
PS50157; ZINC_FINGER_C2H2_2.
XX
IN T21984 p300; human, Homo sapiens.
IN T00545 POU2F1; human, Homo sapiens.
XX
MX M00008 V$SP1_01.
MX M00933 V$SP1_Q2_01.
MX M07395 V$SP1_Q2_02.
MX M00932 V$SP1_Q4_01.
MX M00196 V$SP1_Q6.
MX M00931 V$SP1_Q6_01.
XX
BS R01762.
BS R14212.
BS R14213.
BS R15681.
BS R15353.
BS R03336.
BS R01694.
BS R02381.
BS R01769.
BS R15653.
BS R04025.
XX
DR TRANSPATH: MO000083597.
DR EMBL: AF022363;
DR UniProtKB: O89090-1; SP1_MOUSE.
XX
RN [1]; RE0000182.
RX PUBMED: 2170018.
RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R.
RT GC box binding induces phosphorylation by a DNA-dependent protein kinase
RL Cell 63:155-165 (1990).
RN [2]; RE0000692.
RX PUBMED: 2163346.
RA Saffer J. D., Jackson S. P., Thurston S. J.
RT SV40 stimulates expression of the trans-acting factor Sp1 at the mRNA level
RL Genes Dev. 4:659-666 (1990).
RN [3]; RE0000693.
RX PUBMED: 1851121.
RA Su W., Jackson S., Tjian R., Echols H.
RT DNA looping between site for transcriptional activation: self-association of DNA-bound Sp1
RL Genes Dev. 5:820-826 (1991).
RN [4]; RE0001271.
RX PUBMED: 2181288.
RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., Durviaux S. M., Rousseau G. G.
RT Sp1 can displace GHF-1 from its distal binding site and stimulate transcription from the growth hormone gene promoter
RL Mol. Cell. Biol. 10:1811-1814 (1990).
RN [5]; RE0001375.
RX PUBMED: 2677669.
RA Schmidt M. C., Zhou Q., Berk A. J.
RT Sp1 Activates Transcription without Enhancing DNA-Binding Activity of the TATA Box Factor
RL Mol. Cell. Biol. 9:3299-3307 (1989).
RN [6]; RE0001495.
RX PUBMED: 2005904.
RA Saffer J. D., Jackson S. P., Annarella M. B.
RT Developmental expression of Sp1 in the mouse
RL Mol. Cell. Biol. 11:2189-2199 (1991).
RN [7]; RE0001631.
RX PUBMED: 1710025.
RA Pecorino L. T., Darrow A. L., Strickland S.
RT In vitro analysis of the tissue plasminogen activator promoter reveals a GC box-binding activity present in murine brain but undetectable in kidney and liver
RL Mol. Cell. Biol. 11:3139-3147 (1991).
RN [8]; RE0002175.
RX PUBMED: 1886769.
RA Somma M. P., Gambino I., Lavia P.
RT Transcription factors binding to the mouse HTF9 housekeeping promoter differ between cell types
RL Nucleic Acids Res. 19:4451-4458 (1991).
RN [9]; RE0002618.
RX PUBMED: 3103216.
RA Seguin C., Hamer D. H.
RT Regulation in Vitro of Metallothionein Gene Binding Factors
RL Science 235:1383-1387 (1987).
RN [10]; RE0002766.
RX PUBMED: 2325642.
RA Hirsch M.-R., Gaugler L., Deagostini-Bazin H., Bally-Cuif L., Goridis C.
RT Identification of Positive and Negative Regulatory Elements Governing Cell-Type-Specific Expression of the Neural Cell Adhesion Molecule Gene
RL Mol. Cell. Biol. 10:1959-1968 (1990).
RN [11]; RE0006719.
RX PUBMED: 8016096.
RA Perez J. R., Li Y., Stein C. A., Majumder S., van Oorschot A.
RT Sequence-independent induction of Sp1 trasncription factor activity by phosphorothioate oligodeoxynucleotides
RL Proc. Natl. Acad. Sci. USA 91:5957-5961 (1994).
RN [12]; RE0010577.
RX PUBMED: 7739528.
RA Merika M., Orkin S. H.
RT Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krueppel family proteins Sp1 and EKLF
RL Mol. Cell. Biol. 15:2437-2447 (1995).
RN [13]; RE0016556.
RX PUBMED: 2123467.
RA Sartorelli V., Webster K. A., Kedes L.
RT Muscle-specific expression of the cardiac alpha-actin gene requires MyoD, CArG-box binding factor, and Sp1.
RL Genes Dev. 4:1811-1822 (1990).
RN [14]; RE0064368.
RX PUBMED: 19070619.
RA Lim K., Chang H. I.
RT O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1.
RL FEBS Lett. 583:512-520 (2009).
XX
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