AC T01390
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ID T01390
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DT 09.12.1994 (created); ewi.
DT 15.04.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA GABP-alpha
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SY E4TF1-60; EF-1A alpha; GA binding protein alpha subunit; NRF-2alpha; nuclear respiratory factor 2alpha.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003950 GABPA; HGNC: GABPA.
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CL C0016; ETS; 3.5.2.1.4.
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SF DNA-binding subunit of GABP (E4TF1) [1] [3];
SF for its own, it binds to DNA as a monomer requiring the ETS-domain and N-terminally adjacent sequences [1];
SF modulated in binding to tandem repeat elements by the beta- and gamma-subunits;
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CP broad distribution.
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IN T01391 GABP-beta2; human, Homo sapiens.
IN T10095 GABP-beta; human, Homo sapiens.
IN T01407 GABP-gamma1; human, Homo sapiens.
IN T01392 GABP-gamma2; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
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MX M08881 V$ETSLIKE_Q4.
MX M00971 V$ETS_Q6.
MX M02074 V$GABPA_02.
MX M03990 V$GABPA_06.
MX M04698 V$GABPA_07.
MX M04748 V$GABPA_08.
MX M04944 V$GABPA_09.
MX M08917 V$GABPA_11.
MX M01660 V$GABPA_Q4.
MX M00341 V$GABP_B.
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BS R00357.
BS R01996.
BS R01999.
BS R56828.
BS R20417.
BS R21799.
BS R26409.
BS R28484.
BS R33599.
BS R29737.
BS R26656.
BS R32011.
BS R20483.
BS R20484.
BS R20486.
BS R35577.
BS R35584.
BS R14800.
BS R35574.
BS R20444.
BS R19534.
BS R19535.
BS R39106.
BS R21653.
BS R22307.
BS R28512.
BS R26601.
BS R25904.
BS R25862.
BS R25646.
BS R25648.
BS R28599.
BS R61267.
BS R56152.
BS R29101.
BS R29106.
BS R27945.
BS R26932.
BS R61270.
BS R61276.
BS R03472.
BS R03473.
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DR TRANSPATH: MO000045528.
DR EMBL: D13318;
DR UniProtKB: Q06546;
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RN [1]; RE0000561.
RX PUBMED: 8137823.
RA Sawada J.-I., Goto M., Sawa C., Watanabe H., Handa H.
RT Transcriptional activation through the tetrameric complex formation of E4TF1 subunits
RL EMBO J. 13:1396-1402 (1994).
RN [2]; RE0000801.
RX PUBMED: 8383622.
RA Virbasius J. V., Virbasius C.-M. A., Scarpulla R. C.
RT Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an Ets domain activator of viral promoters
RL Genes Dev. 7:380-392 (1993).
RN [3]; RE0001746.
RX PUBMED: 8441384.
RA Watanabe H., Sawada J.-I., Yano K.-I., Yamaguchi K., Goto M., Handa H.
RT cDNA cloning of transcription factor E4TF1 subunits with Ets and Notch motifs
RL Mol. Cell. Biol. 13:1385-1391 (1993).
RN [4]; RE0014101.
RX PUBMED: 1336180.
RA Bolwig G. M., Bruder J. T., Hearing P.
RT Different binding site requirements for binding and activation for the bipartite enhancer factor EF-1A
RL Nucleic Acids Res. 20:6555-6564 (1992).
RN [5]; RE0048396.
RX PUBMED: 16818466.
RA Presnell S. R., Zhang L., Ramilo C. A., Chan H. W., Lutz C. T.
RT Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter.
RL Int. Immunol. 18:1221-1232 (2006).
RN [6]; RE0052125.
RX PUBMED: 18097041.
RA Zhang Y., Tuzova M., Xiao Z. X., Cruikshank W. W., Center D. M.
RT Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP.
RL J. Immunol. 180:402-408 (2008).
RN [7]; RE0054807.
RX PUBMED: 17495228.
RA Okada Y., Yano K., Jin E., Funahashi N., Kitayama M., Doi T., Spokes K., Beeler D. L., Shih S. C., Okada H., Danilov T. A., Maynard E., Minami T., Oettgen P., Aird W. C.
RT A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.
RL Circ. Res. 100:1712-1722 (2007).
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