AC T01391
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ID T01391
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DT 09.12.1994 (created); ewi.
DT 19.02.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA GABP-beta2
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SY BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GA binding protein beta1 subunit; GA binding protein transcription factor, beta subunit 2, 47kDa; GABPB; GABPB1; GABPB2; NRF-2beta2; NRF2B1; NRF2B2; nuclear respiratory factor 2beta2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003951 GABPB1; HGNC: GABPB1.
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SZ 383 AA; 41.3 kDa (cDNA) (calc.), 53 kDa (SDS)
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SQ MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
SQ GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
SQ ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
SQ PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV
SQ TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA
SQ TDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANREAQKYRQQLLKKE
SQ QEAEAYRQKLEAMTRLQTNKEAV
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SC conceptually translated from EMBL/GenBank/DDBJ #D13317
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FT 1 133 
required for heterodimerization with GABP-alpha (E4TF1-60) [1].
FT 37 66 
SM00248; ANK_2a.
FT 37 69 
PF00023; Ankyrin repeat.
FT 37 69 
PS50088; ANK_REPEAT.
FT 37 156 
PS50297; ANK_REP_REGION.
FT 49 309 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 70 99 
SM00248; ANK_2a.
FT 70 102 
PF00023; Ankyrin repeat.
FT 70 102 
PS50088; ANK_REPEAT.
FT 103 132 
SM00248; ANK_2a.
FT 103 135 PF00023; Ankyrin repeat.
FT 103 135 PS50088; ANK_REPEAT.
FT 136 166 SM00248; ANK_2a.
FT 334 383 homodimerization, trans-activation [1].
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SF identical with NRF-2beta2;
SF 4 tandem notch-ankyrin repeats;
SF splice variants are GABP-beta2 (E4TF1-47, NRF-2gamma2) T01392, NRF-2gamma1 T01407, and NRF-2beta1 T01406;
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CP broad distribution.
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FF non-DNA-binding subunit of GABP (E4TF1);
FF homo- and heterodimerizes;
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IN T01390 GABP-alpha; human, Homo sapiens.
IN T01391 GABP-beta2; human, Homo sapiens.
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MX M00971 V$ETS_Q6.
MX M01876 V$GABPBETA_Q3.
MX M00341 V$GABP_B.
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BS R00357.
BS R03472.
BS R03473.
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DR TRANSPATH: MO000005460.
DR EMBL: D13317;
DR EMBL: U13046;
DR UniProtKB: Q06547-2;
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RN [1]; RE0000561.
RX PUBMED: 8137823.
RA Sawada J.-I., Goto M., Sawa C., Watanabe H., Handa H.
RT Transcriptional activation through the tetrameric complex formation of E4TF1 subunits
RL EMBO J. 13:1396-1402 (1994).
RN [2]; RE0000801.
RX PUBMED: 8383622.
RA Virbasius J. V., Virbasius C.-M. A., Scarpulla R. C.
RT Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an Ets domain activator of viral promoters
RL Genes Dev. 7:380-392 (1993).
RN [3]; RE0001746.
RX PUBMED: 8441384.
RA Watanabe H., Sawada J.-I., Yano K.-I., Yamaguchi K., Goto M., Handa H.
RT cDNA cloning of transcription factor E4TF1 subunits with Ets and Notch motifs
RL Mol. Cell. Biol. 13:1385-1391 (1993).
RN [4]; RE0014101.
RX PUBMED: 1336180.
RA Bolwig G. M., Bruder J. T., Hearing P.
RT Different binding site requirements for binding and activation for the bipartite enhancer factor EF-1A
RL Nucleic Acids Res. 20:6555-6564 (1992).
RN [5]; RE0052125.
RX PUBMED: 18097041.
RA Zhang Y., Tuzova M., Xiao Z. X., Cruikshank W. W., Center D. M.
RT Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP.
RL J. Immunol. 180:402-408 (2008).
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