AC T09948
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ID T09948
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DT 23.11.2006 (created); kau.
DT 07.12.2006 (updated); kau.
CO Copyright (C), QIAGEN.
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FA BF-1
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SY BF-1; brain factor 1; c-Qin.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009113 Foxg1.
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CL C0023; fork head.
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SZ 481 AA; 51.6 kDa (cDNA) (calc.), 51.6 kDa (cDNA) [4]
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SQ MLDMGDRKEVKMIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHPPPP
SQ APQPPPPPPQQQQQQPPPAPQPPQARGAPAADDDKGPQPLLLPPSTALDGAKADALGAKG
SQ EPGGGPAELAPVGPDEKEKGAGAGGEEKKGAGEGGKDGEGGKEGDKKNGKYEKPPFSYNA
SQ LIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDD
SQ PGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYW
SQ PMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTANGLSVDRLV
SQ NGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTS
SQ QTSTSMSARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQGSSSNPLI
SQ H
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SC Swiss-Prot#Q60987
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FT 3 479 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 171 261 
SM00339; forkneu4.
FT 172 263 
fork head homology [4].
FT 173 267 
PS50039; FORK_HEAD_3.
FT 173 268 
PF00250; Fork head domain.
FT 276 336 
interaction with TLE1 [8].
FT 276 372 
interaction with FAST-2 [10].
FT 299 309 
conserved between different species [8].
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IN T21852 HDAC1; Mammalia.
IN T09897 HES-1; rat, Rattus norvegicus.
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DR TRANSPATH: MO000093129.
DR UniProtKB: Q60987; BF1_MOUSE.
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RN [1]; RE0006641.
RX PUBMED: 7815060.
RA Hatini V., Lao W., Lai E.
RT Expression of Winged Helix Genes, BF-1 and BF-2, Define Adjacent Domains within the Developing Forbrain and Retina
RL J. Neurobiol. 25:1293-1309 (1994).
RN [2]; RE0006645.
RX PUBMED: 7789972.
RA Avraham K. B., Fletcher C., Overdier D. G., Clevidence D. E., Lai E., Costa R. H., Jenkins N. A., Copeland N. G.
RT Murine Chromosomal Location of Eight Members of the Hepatocyte Nuclear Factor 3/Fork Head Winged Helix Family of Transcription Factors
RL Genomics 25:388-393 (1995).
RN [3]; RE0006646.
RX PUBMED: 7605629.
RA Xuan S., Baptista C. A., Balas G., Tao W., Soares V. C., Lai E.
RT Winged Helix Transcription Factor BF-1 is Essential for the Development of the Crebral Hemispheres
RL Neuron 14:1141-1152 (1995).
RN [4]; RE0006647.
RX PUBMED: 8738140.
RA Li H., Tao W., Lai E.
RT Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain development
RL Mol. Brain Res. 37:96-104 (1996).
RN [5]; RE0006697.
RX PUBMED: 9226442.
RA Shimamura K., Rubenstein J. L. R.
RT Inductive interactions direct early regionalization of the mouse forebrain
RL Development 124:2709-2718 (1997).
RN [6]; RE0023704.
RX PUBMED: 12351726.
RA Pratt T., Quinn J. C., Simpson T. I., West J. D., Mason J. O., Price D. J.
RT Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1.
RL J. Neurosci. 22:8523-8531 (2002).
RN [7]; RE0023705.
RX PUBMED: 14704420.
RA Hanashima C., Li S. C., Shen L., Lai E., Fishell G.
RT Foxg1 suppresses early cortical cell fate.
RL Science 303:56-59 (2004).
RN [8]; RE0023713.
RX PUBMED: 11238932.
RA Yao J., Lai E., Stifani S.
RT The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.
RL Mol. Cell. Biol. 21:1962-1972 (2001).
RN [9]; RE0023714.
RX PUBMED: 11387330.
RA Rodriguez C., Huang L. J., Son J. K., McKee A., Xiao Z., Lodish H. F.
RT Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling.
RL J. Biol. Chem. 276:30224-30230 (2001).
RN [10]; RE0023715.
RX PUBMED: 10938097.
RA Dou C., Lee J., Liu B., Liu F., Massague J., Xuan S., Lai E.
RT BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners.
RL Mol. Cell. Biol. 20:6201-6211 (2000).
RN [11]; RE0048295.
RX PUBMED: 16691564.
RA Pauley S., Lai E., Fritzsch B.
RT Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear.
RL Dev. Dyn. 235:2470-2482 (2006).
RN [12]; RE0048296.
RX PUBMED: 15893304.
RA Martynoga B., Morrison H., Price D. J., Mason J. O.
RT Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis.
RL Dev. Biol. 283:113-127 (2005).
RN [13]; RE0048298.
RX PUBMED: 15858069.
RA Muzio L., Mallamaci A.
RT Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium.
RL J. Neurosci. 25:4435-4441 (2005).
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