TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T09897 XX ID T09897 XX DT 10.11.2006 (created); lyn. DT 03.07.2015 (updated); sup. CO Copyright (C), QIAGEN. XX FA HES-1 XX SY hairy and enhancer of split 1 (Drosophila); Hes1; RHL. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014485 Hes1. XX CL C0010; bHLH. XX SZ 281 AA; 29.6 kDa (cDNA) (calc.). XX SQ MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL SQ ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE SQ VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPGGPQHA SQ PFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFA SQ HSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWRPWRN XX SC Swiss-Prot#Q04666 XX FT 34 92 PS50888; HLH. FT 35 92 PF00010; Helix-loop-helix DNA-binding domain. FT 40 97 SM00353; finulus. FT 108 152 PF07527; Hairy Orange. FT 108 152 SM00511; ORANGE. FT 110 143 PS51054; ORANGE. XX IN T09948 BF-1; mouse, Mus musculus. IN T02524 Grg-1; human, Homo sapiens. IN T09927 Grg-1; human, Homo sapiens. IN T25008 pRb; Mammalia. IN T19198 PTF1A; rat, Rattus norvegicus. XX MX M01009 V$HES1_Q2. MX M07042 V$HES1_Q3. MX M07420 V$HES1_Q4. MX M02011 V$HES1_Q6. XX BS R22854. BS R36146. BS R36152. BS R36154. BS R36156. BS R36157. BS R73735. BS R73736. BS R66263. BS R28165. BS R25445. BS R68633. BS R68634. BS R68636. BS R68637. BS R68638. BS R68635. XX DR TRANSPATH: MO000091448. DR EMBL: D13417; DR UniProtKB: Q04666; XX RN [1]; RE0003677. RX PUBMED: 1340473. RA Sasai Y., Kageyama R., Tagawa Y., Shigemoto R., Nakanishi S. RT Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split RL Genes Dev. 6:2620-2634 (1992). RN [2]; RE0003678. RX PUBMED: 8417318. RA Feder J. N., Jan L. Y., Jan Y.-N. RT A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation RL Mol. Cell. Biol. 13:105-113 (1993). RN [3]; RE0023713. RX PUBMED: 11238932. RA Yao J., Lai E., Stifani S. RT The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. RL Mol. Cell. Biol. 21:1962-1972 (2001). RN [4]; RE0048845. RX PUBMED: 8687460. RA Grbavec D., Stifani S. RT Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. RL Biochem. Biophys. Res. Commun. 223:701-705 (1996). RN [5]; RE0048885. RX PUBMED: 16201968. RA Ghosh B., Leach S. D. RT Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex. RL Biochem. J. 393:679-685 (2006). RN [6]; RE0048954. RX PUBMED: 16753023. RA Lee J. S., Thomas D. M., Gutierrez G., Carty S. A., Yanagawa S., Hinds P. W. RT HES1 cooperates with pRb to activate RUNX2-dependent transcription. RL J. Bone Miner. Res. 21:921-933 (2006). XX //