AC T09897
XX
ID T09897
XX
DT 10.11.2006 (created); lyn.
DT 03.07.2015 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA HES-1
XX
SY hairy and enhancer of split 1 (Drosophila); Hes1; RHL.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G014485 Hes1.
XX
CL C0010; bHLH.
XX
SZ 281 AA; 29.6 kDa (cDNA) (calc.).
XX
SQ MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL
SQ ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE
SQ VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPGGPQHA
SQ PFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFA
SQ HSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWRPWRN
XX
SC Swiss-Prot#Q04666
XX
FT 34 92 
PS50888; HLH.
FT 35 92 
PF00010; Helix-loop-helix DNA-binding domain.
FT 40 97 
SM00353; finulus.
FT 108 152 
PF07527; Hairy Orange.
FT 108 152 
SM00511; ORANGE.
FT 110 143 
PS51054; ORANGE.
XX
IN T09948 BF-1; mouse, Mus musculus.
IN T02524 Grg-1; human, Homo sapiens.
IN T09927 Grg-1; human, Homo sapiens.
IN T25008 pRb; Mammalia.
IN T19198 PTF1A; rat, Rattus norvegicus.
XX
MX M01009 V$HES1_Q2.
MX M07042 V$HES1_Q3.
MX M07420 V$HES1_Q4.
MX M02011 V$HES1_Q6.
XX
BS R22854.
BS R36146.
BS R36152.
BS R36154.
BS R36156.
BS R36157.
BS R73735.
BS R73736.
BS R66263.
BS R28165.
BS R25445.
BS R68633.
BS R68634.
BS R68636.
BS R68637.
BS R68638.
BS R68635.
XX
DR TRANSPATH: MO000091448.
DR EMBL: D13417;
DR UniProtKB: Q04666;
XX
RN [1]; RE0003677.
RX PUBMED: 1340473.
RA Sasai Y., Kageyama R., Tagawa Y., Shigemoto R., Nakanishi S.
RT Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
RL Genes Dev. 6:2620-2634 (1992).
RN [2]; RE0003678.
RX PUBMED: 8417318.
RA Feder J. N., Jan L. Y., Jan Y.-N.
RT A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation
RL Mol. Cell. Biol. 13:105-113 (1993).
RN [3]; RE0023713.
RX PUBMED: 11238932.
RA Yao J., Lai E., Stifani S.
RT The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.
RL Mol. Cell. Biol. 21:1962-1972 (2001).
RN [4]; RE0048845.
RX PUBMED: 8687460.
RA Grbavec D., Stifani S.
RT Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.
RL Biochem. Biophys. Res. Commun. 223:701-705 (1996).
RN [5]; RE0048885.
RX PUBMED: 16201968.
RA Ghosh B., Leach S. D.
RT Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex.
RL Biochem. J. 393:679-685 (2006).
RN [6]; RE0048954.
RX PUBMED: 16753023.
RA Lee J. S., Thomas D. M., Gutierrez G., Carty S. A., Yanagawa S., Hinds P. W.
RT HES1 cooperates with pRb to activate RUNX2-dependent transcription.
RL J. Bone Miner. Res. 21:921-933 (2006).
XX
//