AC T02524
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ID T02524
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DT 04.11.1998 (created); ili.
DT 29.04.2008 (updated); grs.
CO Copyright (C), QIAGEN.
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FA Grg-1
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SY Grg-1; GRG1; Groucho-related protein 1; transducin-like enhancer of split 1; transducin-like enhancer protein.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004006 TLE1; HGNC: TLE1.
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HO Groucho (Drosophila).
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SF similar to groucho;
SF differentially phosphorylated forms [1];
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CP several epithelial tissues [2]; immature, proliferating cells in transition to the terminally differentiated state [2] [2].
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FF elevated levels in cervical and colonic neoplasias [2];
FF organized in a tandem array with TLE2 at chromosomal location 19p13.3 [2];
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IN T02266 AML3-isoform2; mouse, Mus musculus.
IN T02852 FBP; human, Homo sapiens.
IN T09897 HES-1; rat, Rattus norvegicus.
IN T08453 Hex; human, Homo sapiens.
IN T10718 RPA2; human, Homo sapiens.
IN T19402 zfp64; human, Homo sapiens.
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DR TRANSPATH: MO000026504.
DR UniProtKB: Q04724;
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RN [1]; RE0007017.
RX PUBMED: 8713081.
RA Hsain J., Lo R., Grbavec D., Stifani S.
RT Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions
RL Biochem. J. 317:523-531 (1996).
RN [2]; RE0007018.
RX PUBMED: 8808280.
RA Liu Y., Dehni G., Purcell K. J., Sokolow J., Carcangiu M. L., Artavanis-Tsakonas S., Stifani S.
RT Epithelial expression and chromosomal location of human TLE genes: implictions for Notch signalling and neoplasia
RL Genomics 31:58-64 (1996).
RN [3]; RE0023713.
RX PUBMED: 11238932.
RA Yao J., Lai E., Stifani S.
RT The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.
RL Mol. Cell. Biol. 21:1962-1972 (2001).
RN [4]; RE0048845.
RX PUBMED: 8687460.
RA Grbavec D., Stifani S.
RT Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.
RL Biochem. Biophys. Res. Commun. 223:701-705 (1996).
RN [5]; RE0052757.
RX PUBMED: 15187083.
RA Swingler T. E., Bess K. L., Yao J., Stifani S., Jayaraman P. S.
RT The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells.
RL J. Biol. Chem. 279:34938-34947 (2004).
RN [6]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
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