AC T08453
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ID T08453
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DT 23.01.2006 (created); din.
DT 06.03.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Hex
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SY hematopoietically expressed homeobox; HEX; HHEX; HMPH; HOX11L-PEN; Prh; PRHX.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006200 HHEX; HGNC: HHEX.
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CL C0006; homeo.
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SZ 270 AA; 30.0 kDa (cDNA) (calc.).
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SQ MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAAPTPAPTLPSPNSSFTS
SQ LVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPL
SQ GKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQ
SQ VKTWFQNRRAKWRRLKQENPQSNKKEELESLDSSCDQRQDLPSEQNKGASLDSSQCSPSP
SQ ASQEDLESEISEDSDQEVDIEGDKSYFNAG
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SC Swiss-Prot#Q03014
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FT 135 195 
PS50071; HOMEOBOX_2.
FT 136 199 
SM00389; HOX_1.
FT 138 194 
PF00046; Homeobox domain.
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IN T08571 GATA-2-isoform1; human, Homo sapiens.
IN T09925 GATA-3; human, Homo sapiens.
IN T10207 GATA-6short; human, Homo sapiens.
IN T02524 Grg-1; human, Homo sapiens.
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DR TRANSPATH: MO000058233.
DR EMBL: L16499;
DR EMBL: X67235;
DR UniProtKB: Q03014;
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RN [1]; RE0052757.
RX PUBMED: 15187083.
RA Swingler T. E., Bess K. L., Yao J., Stifani S., Jayaraman P. S.
RT The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells.
RL J. Biol. Chem. 279:34938-34947 (2004).
RN [2]; RE0052773.
RX PUBMED: 12826010.
RA Bess K. L., Swingler T. E., Rivett A. J., Gaston K., Jayaraman P. S.
RT The transcriptional repressor protein PRH interacts with the proteasome.
RL Biochem. J. 374:667-675 (2003).
RN [3]; RE0052795.
RX PUBMED: 16540119.
RA Soufi A., Smith C., Clarke A. R., Gaston K., Jayaraman P. S.
RT Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.
RL J. Mol. Biol. 358:943-962 (2006).
RN [4]; RE0052827.
RX PUBMED: 15016828.
RA Minami T., Murakami T., Horiuchi K., Miura M., Noguchi T., Miyazaki J., Hamakubo T., Aird W. C., Kodama T.
RT Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.
RL J. Biol. Chem. 279:20626-20635 (2004).
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