AC T09927
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ID T09927
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DT 21.11.2006 (created); kau.
DT 31.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Grg-1
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SY transducin-like enhancer of split 1; transducin-like enhancer protein.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004006 TLE1; HGNC: TLE1.
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SZ 770 AA; 83.2 kDa (cDNA) (calc.), 90 kDa (SDS) [1], 93 kDa (SDS) [1] [1]
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SQ MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH
SQ YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN
SQ AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK
SQ DDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSD
SQ GDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSLK
SQ SKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRT
SQ PLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVG
SQ FDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINT
SQ LNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP
SQ DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV
SQ WDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQI
SQ FSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDN
SQ LLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
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SC Swiss Prot #Q04724
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FT 1 136 
PF03920; TLE_N.
FT 474 511 
SM00320; WD40_4.
FT 475 511 
PF00400; WD40.
FT 480 653 
PS50294; WD_REPEATS_REGION.
FT 517 558 
SM00320; WD40_4.
FT 531 558 
PF00400; WD40.
FT 563 602 
SM00320; WD40_4.
FT 564 602 
PF00400; WD40.
FT 570 611 
PS50082; WD_REPEATS_2.
FT 605 644 
SM00320; WD40_4.
FT 606 644 PF00400; WD40.
FT 612 653 PS50082; WD_REPEATS_2.
FT 647 685 SM00320; WD40_4.
FT 687 726 SM00320; WD40_4.
FT 688 726 PF00400; WD40.
FT 694 770 PS50294; WD_REPEATS_REGION.
FT 727 767 SM00320; WD40_4.
FT 739 767 PF00400; WD40.
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IN T09897 HES-1; rat, Rattus norvegicus.
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DR TRANSPATH: MO000092663.
DR EMBL: M99435;
DR UniProtKB: Q04724;
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RN [1]; RE0007017.
RX PUBMED: 8713081.
RA Hsain J., Lo R., Grbavec D., Stifani S.
RT Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions
RL Biochem. J. 317:523-531 (1996).
RN [2]; RE0007018.
RX PUBMED: 8808280.
RA Liu Y., Dehni G., Purcell K. J., Sokolow J., Carcangiu M. L., Artavanis-Tsakonas S., Stifani S.
RT Epithelial expression and chromosomal location of human TLE genes: implictions for Notch signalling and neoplasia
RL Genomics 31:58-64 (1996).
RN [3]; RE0048845.
RX PUBMED: 8687460.
RA Grbavec D., Stifani S.
RT Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.
RL Biochem. Biophys. Res. Commun. 223:701-705 (1996).
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