AC T08519
XX
ID T08519
XX
DT 01.02.2006 (created); ili.
DT 11.02.2015 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA C2TA-isoform1
XX
SY C2TA; Class II TransActivator.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002341 CIITA; HGNC: CIITA.
XX
SZ 1130 AA; 123.4 kDa (cDNA) (calc.).
XX
SQ MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEE
SQ EIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFK
SQ HIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCS
SQ TLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGL
SQ WQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSM
SQ PEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGIL
SQ VEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLG
SQ KAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAA
SQ DEVFSHILKRPDRVLLILDAFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRG
SQ CTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRD
SQ RPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAEL
SQ AKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGAL
SQ WLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAA
SQ SVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRL
SQ TPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLR
SQ QHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKL
SQ EFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETL
SQ NLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQ
SQ YNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR
XX
SC translated from EMBL:U18259
XX
FT 1 161 
activation domain [2].
FT 51 71 
alpha-helix 1, ah1 [2].
FT 84 103 
alpha-helix 2, ah2 [2].
FT 124 138 
alpha-helix 3, ah3 [2].
FT 163 322 
P/S/T domain [3].
FT 200 567 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 299 1129 
interaction with RFX5 [4].
FT 414 585 
PF05729; NACHT domain.
FT 414 724 
PS50837; NACHT.
FT 421 561 
homology to the G1, G3, G4 domains of a GTP-binding motif [3].
FT 465 469 leucine charged domain (LCD motif), L1 [1].
FT 525 529 leucine charged domain (LCD motif), L2 [1].
FT 983 1013 SM00368; LRR_RI.
FT 995 1079 PS50503; LRR_RI.
FT 1014 1041 SM00368; LRR_RI.
FT 1016 1039 PF00560; LRR_1.
FT 1043 1070 SM00368; LRR_RI.
FT 1071 1098 SM00368; LRR_RI.
XX
IN T04106 HDAC1; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
IN T08967 NF-YB; rat, Rattus norvegicus.
IN T08521 rfx5-isoform1; human, Homo sapiens.
IN T09238 TAFII55; human, Homo sapiens.
XX
DR TRANSPATH: MO000059554.
DR EMBL: U18259;
DR UniProtKB: P33076;
XX
RN [1]; RE0022540.
RX PUBMED: 9722631.
RA Brown J. A., Rogers E. M., Boss J. M.
RT The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element.
RL Nucleic Acids Res. 26:4128-4136 (1998).
RN [2]; RE0022565.
RX PUBMED: 9171108.
RA Fontes J. D., Jiang B., Peterlin B. M.
RT The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.
RL Nucleic Acids Res. 25:2522-2528 (1997).
RN [3]; RE0022567.
RX PUBMED: 9122224.
RA Chin K. C., Li G. G., Ting J. P-Y.
RT Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants.
RL Proc. Natl. Acad. Sci. USA 94:2501-2506 (1997).
RN [4]; RE0022569.
RX PUBMED: 9177217.
RA Scholl T., Mahanta S. K., Strominger J. L.
RT Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5.
RL Proc. Natl. Acad. Sci. USA 94:6330-6334 (1997).
RN [5]; RE0022578.
RX PUBMED: 11003667.
RA Hake S. B., Masternak K., Kammerbauer C., Janzen C., Reith W., Steimle V.
RT CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.
RL Mol. Cell. Biol. 20:7716-7725 (2000).
RN [6]; RE0047781.
RX PUBMED: 12697811.
RA Zika E., Greer S. F., Zhu X. S., Ting J. P.
RT Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation.
RL Mol. Cell. Biol. 23:3091-3102 (2003).
XX
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