AC T08521
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ID T08521
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DT 01.02.2006 (created); ili.
CO Copyright (C), QIAGEN.
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FA rfx5-isoform1
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SY regulatory factor X, 5 (influences HLA class II expression); RFX5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005106 RFX5; HGNC: RFX5.
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CL C0023; fork head.
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SZ 616 AA; 65.3 kDa (cDNA) (calc.), 75 kDa (SDS) [6]
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SQ MAEDEPDAKSPKTGGRAPPGGAEAGEPTTLLQRLRGTISKAVQNKVEGILQDVQKFSDND
SQ KLYLYLQLPSGPTTGDKSSEPSTLSNEEYMYAYRWIRNHLEEHTDTCLPKQSVYDAYRKY
SQ CESLACCRPLSTANFGKIIREIFPDIKARRLGGRGQSKYCYSGIRRKTLVSMPPLPGLDL
SQ KGSESPEMGPEVTPAPRDELVEAACALTCDWAERILKRSFSSIVEVARFLLQQHLISARS
SQ AHAHVLKAMGLAEEDEHAPRERSSKPKNGLENPEGGAHKKPERLAQPPKDLEARTGAGPL
SQ ARGERKKSVVESSAPGANNLQVNALVARLPLLLPRAPRSLIPPIPVSPPILAPRLSSGAL
SQ KVATLPLSSRAGAPPAAVPIINMILPTVPALPGPGPGPGRAPPGGLTQPRGTENREVGIG
SQ GDQGPHDKGVKRTAEVPVSEASGQAPPAKAAKQDIEDTASDAKRKRGRPRKKSGGSGERN
SQ STPLKSAAAMESAQSSRLPWETWGSGGEGNSAGGAERPGPMGEAEKGAVLAQGQGDGTVS
SQ KGGRGPGSQHTKEAEDKIPLVPSKVSVIKGSRSQKEAFPLAKGEVDTAPQGNKDLKEHVL
SQ QSSLSQEHKDPKATPP
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SC translated from EMBL #BC017471
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FT 1 92 
important for RFX complex formation [3].
FT 62 68 
leucine-rich stretch [4].
FT 76 158 
PF02257; RFX DNA-binding domain.
FT 92 166 
DNA binding domain, DBD [2].
FT 93 99 
alpha-helix 1, H1 [1].
FT 100 109 
beta-strand 1, S1 [1].
FT 110 123 
alpha-helix 2, H2 [1].
FT 124 130 
connecting loop 1, L1 [1].
FT 131 141 
alpha-helix 3, H3 [1].
FT 142 145 
connecting loop 2, L2 [1].
FT 146 150 beta-strand 2, S2 [1].
FT 151 156 wing, W1 [1].
FT 157 166 beta-strand 3, S3 [1].
FT 157 574 PF00478; IMP dehydrogenase / GMP reductase dom.
FT 201 410 important for RFX complex formation [3].
FT 330 409 proline-rich region (22/80), interaction with CIITA [3].
FT 463 475 PF02178; AT_hook.
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IN T08519 C2TA-isoform1; human, Homo sapiens.
IN T05441 RFXANK; human, Homo sapiens.
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DR TRANSPATH: MO000059556.
DR EMBL: BC017471;
DR EMBL: X85786;
DR UniProtKB: P48382;
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RN [1]; RE0022520.
RX PUBMED: 10706293.
RA Gajiwala K. S., Chen H., Cornille F., Roques B. P., Reith W., Mach B., Burley S. K.
RT Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.
RL Nature 403:916-921 (2000).
RN [2]; RE0022529.
RX PUBMED: 10779326.
RA Villard J., Peretti M., Masternak K., Barras E., Caretti G., Mantovani R., Reith W.
RT A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.
RL Mol. Cell. Biol. 20:3364-3376 (2000).
RN [3]; RE0022539.
RX PUBMED: 10938133.
RA DeSandro A. M., Nagarajan U. M., Boss J. M.
RT Associations and interactions between bare lymphocyte syndrome factors.
RL Mol. Cell. Biol. 20:6587-6599 (2000).
RN [4]; RE0022593.
RX PUBMED: 12101253.
RA Jabrane-Ferrat N., Nekrep N., Tosi G., Esserman L. J., Peterlin B. M.
RT Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimers.
RL Mol. Cell. Biol. 22:5616-5625 (2002).
RN [5]; RE0047781.
RX PUBMED: 12697811.
RA Zika E., Greer S. F., Zhu X. S., Ting J. P.
RT Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation.
RL Mol. Cell. Biol. 23:3091-3102 (2003).
RN [6]; RE0003797.
RX PUBMED: 7744245.
RA Steimle V., Durand B., Barras E., Zufferey M., Hadam M. R., Mach B., Reith W.
RT A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymophocyte syndrome)
RL Genes Dev. 9:1021-1032 (1995).
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