AC T09040
AS T00467.
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ID T09040
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DT 09.06.2006 (created); sla.
DT 22.01.2016 (updated); smt.
CO Copyright (C), QIAGEN.
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FA HNF-1beta
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SY AID1; hepatocyte nuclear factors 2; HNF-2; HNF1B; HNF1beta; HNF2; LF-A1; LFA1; LFB3; MODY5; TCF2; transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor; vHNF1; vHNF1-C.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004673 HNF1B; HGNC: HNF1B.
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HO NF-BA1.
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CL C0007; POU; 3.1.10.7.2.
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CP liver; Papillary cancer cell lines, BHP 2-7, BHP 7-13, BHP 10-3, BHP 18-21, and TPC 1, liver cancer cell line Hep G2, and prostate cancer cell line LNCaP [4].
CN papillary cancer cell lines BHP 5-16, BHP 14-9, BHP 15-3, and NPA 87, follicular cancer cell lines WRO 82-1, FTC 133, FTC 238, ML-1A, and ML-1B, Hurthle cancer cell line XTC-1, breast cancer cell line MCF-7, and primary thyroid cell cultures, O4 (goiter) and HX5 (normal) [4].
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FF different from Tf-LF1/2;
FF Expression of HNF-1beta increased NNMT promoter activity as well as endogenous NNMT protein level [4];
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IN T15118 CBP; Mammalia.
IN T08343 HDAC1; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
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MX M01425 V$HNF1B_01.
MX M02266 V$HNF1B_04.
MX M03826 V$HNF1B_Q6.
MX M03872 V$HNF1B_Q6_01.
MX M00790 V$HNF1_Q6.
MX M01011 V$HNF1_Q6_01.
MX M00646 V$LFA1_Q6.
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BS R71542.
BS R00135.
BS R03662.
BS R36202.
BS R40249.
BS R61095.
BS R57881.
BS R25715.
BS R26538.
BS R19748.
BS R61082.
BS R61085.
BS R41635.
BS R36257.
BS R02192.
BS R38656.
BS R38657.
BS R32896.
BS R00439.
BS R01171.
BS R21051.
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DR TRANSPATH: MO000082711.
DR UniProtKB: P35680; HNFB_HUMAN.
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RN [1]; RE0001959.
RX PUBMED: 2911463.
RA Ochoa A., Brunel F., Mendelzon D., Cohen G. N., Zakin M. M.
RT Different liver nuclear proteins bind to similar sequences in the 5' flanking regions of three hepatic genes
RL Nucleic Acids Res. 17:119-133 (1989).
RN [2]; RE0002093.
RX PUBMED: 2020548.
RA Ramji D. P., Tadros M. H., Hardon E. M., Cortese R.
RT The transcription factor LF-A1 interacts with a bipartite recognition sequence in the promoter regions of several liver-specific genes
RL Nucleic Acids Res. 19:1139-1146 (1991).
RN [3]; RE0038781.
RX PUBMED: 12855703.
RA Isshiki S., Kudo T., Nishihara S., Ikehara Y., Togayachi A., Furuya A., Shitara K., Kubota T., Watanabe M., Kitajima M., Narimatsu H.
RT Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins
RL J. Biol. Chem. 278:36611-20 (2003).
RN [4]; RE0048616.
RX PUBMED: 15486044.
RA Xu J., Capezzone M., Xu X., Hershman J. M.
RT Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells.
RL Mol. Endocrinol. 19:527-539 (2005).
RN [5]; RE0052368.
RX PUBMED: 16616718.
RA Shimakura J., Terada T., Shimada Y., Katsura T., Inui K.
RT The transcription factor Cdx2 regulates the intestine-specific expression of human peptide transporter 1 through functional interaction with Sp1.
RL Biochem. Pharmacol. 71:1581-1588 (2006).
RN [6]; RE0052991.
RX PUBMED: 15509593.
RA Barbacci E., Chalkiadaki A., Masdeu C., Haumaitre C., Lokmane L., Loirat C., Cloarec S., Talianidis I., Bellanne-Chantelot C., Cereghini S.
RT HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment.
RL Hum. Mol. Genet. 13:3139-3149 (2004).
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