AC T27185
XX
ID T27185
XX
DT 21.08.2006 (created); ran.
DT 05.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
XX
FA Dnmt1-L
XX
SY CXXC9; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase MmuI; DNA MTase MmuI; DNMT; DNMT1; Dnmt1-long isoform; Dnmt1o; M.MmuI; MCMT; Met-1; Met1; MTase.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G037211 Dnmt1.
XX
CL C0070; CXXC; 2.6.1.0.6.1.
XX
SZ 1620 AA; 183.2 kDa (calc.).
XX
SQ MPARTAPARVPALASPAGSLPDHVRRRLKDLERDGLTEKECVREKLNLLHEFLQTEIKSQ
SQ LCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGTHTLTQKANGCPANGSRPTWRAEMA
SQ DSNRSPRSRPKPRGPRRSKSDSDTLSVETSPSSVATRRTTRQTTITAHFTKGPTKRKPKE
SQ ESEEGNSAESAAEERDQDKKRRVVDTESGAAAAVEKLEEVTAGTQLGPEEPCEQEDDNRS
SQ LRRHTRELSLRRKSKEDPDREARPETHLDEDEDGKKDKRSSRPRSQPRDPAAKRRPKEAE
SQ PEQVAPETPEDRDEDEREEKRRKTTRKKLESHTVPVQSRSERKAAQSKSVIPKINSPKCP
SQ ECGQHLDDPNLKYQQHPEDAVDEPQMLTSEKLSIYDSTSTWFDTYEDSPMHRFTSFSVYC
SQ SRGHLCPVDTGLIEKNVELYFSGCAKAIHDENPSMEGGINGKNLGPINQWWLSGFDGGEK
SQ VLIGFSTAFAEYILMEPSKEYEPIFGLMQEKIYISKIVVEFLQNNPDAVYEDLINKIETT
SQ VPPSTINVNRFTEDSLLRHAQFVVSQVESYDEAKDDDETPIFLSPCMRALIHLAGVSLGQ
SQ RRATRRVMGATKEKDKAPTKATTTKLVYQIFDTFFSEQIEKYDKEDKENAMKRRRCGVCE
SQ VCQQPECGKCKACKDMVKFGGTGRSKQACLKRRCPNLAVKEADDDEEADDDVSEMPSPKK
SQ LHQGKKKKQNKDRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLA
SQ RVTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYIHSKVKVIYK
SQ APSENWAMEGGTDPETTLPGAEDGKTYFFQLWYNQEYARFESPPKTQPTEDNKHKFCLSC
SQ IRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSVYLPPEAFTFNIKVASPV
SQ KRPKKDPVNETLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIHCGKKKGKVNEADIKLR
SQ LYKFYRPENTHRSYNGSYHTDINMLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQ
SQ GGPDRFYFLEAYNSKTKNFEDPPNHARSPGNKGKGKGKGKGKGKHQVSEPKEPEAAIKLP
SQ KLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKL
SQ VMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDY
SQ YRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILA
SQ AAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEI
SQ QNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSPLVAARMRHIPLFPGSDWR
SQ DLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGALRGVCSCAEGKACDPESRQFSTLIPW
SQ CLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQG
SQ FPDSYRFFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLLSSARESASAAVKAKEEAATKD
XX
SC Swiss-Prot#P13864-1
XX
FT 16 106 
PF06464; DMAP_binding.
FT 648 694 
PF02008; zf-CXXC.
FT 649 695 
PS51058; ZF_CXXC.
FT 758 884 
PF01426; BAH.
FT 758 884 
PS51038; BAH.
FT 758 884 
SM00439; BAH_4.
FT 935 1103 
SM00439; BAH_4.
FT 970 1103 
PF01426; BAH.
FT 976 1103 
PS51038; BAH.
FT 1142 1596 
PF00145; DNA_methylase.
XX
IN T21852 HDAC1; Mammalia.
IN T15675 Hesx1; Mammalia.
XX
DR TRANSPATH: MO000085393.
DR UniProtKB: P13864-1; DNMT1_MOUSE.
XX
RN [1]; RE0048111.
RX PUBMED: 12354094.
RA Iida T., Suetake I., Tajima S., Morioka H., Ohta S., Obuse C., Tsurimoto T.
RT PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA.
RL Genes Cells 7:997-1007 (2002).
RN [2]; RE0052243.
RX PUBMED: 10615135.
RA Fuks F., Burgers W. A., Brehm A., Hughes-Davies L., Kouzarides T.
RT DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
RL Nat. Genet. 24:88-91 (2000).
RN [3]; RE0066070.
RX PUBMED: 19243219.
RA Bossuyt W., Kazanjian A., De Geest N., Van Kelst S., De Hertogh G., Geboes K., Boivin G. P., Luciani J., Fuks F., Chuah M., VandenDriessche T., Marynen P., Cools J., Shroyer N. F., Hassan B. A.
RT Atonal homolog 1 is a tumor suppressor gene.
RL PLoS Biol. 7:e39 (2009).
XX
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