AC T09957
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ID T09957
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DT 10.03.2005 (created); nvo.
DT 15.04.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA PPARbeta
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SY PPAR-delta.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T21852 HDAC1; Mammalia.
IN T02752 LXR-alpha; human, Homo sapiens.
IN T09029 LXR-beta; human, Homo sapiens.
IN T09964 RXR-alpha; Mammalia.
IN T21552 SRC-1; Mammalia.
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MX M00763 V$PPARDR1_Q2.
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DR TRANSPATH: MO000046491.
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RN [1]; RE0014098.
RX PUBMED: 10555149.
RA He T. C., Chan T. A., Vogelstein B., Kinzler K. W.
RT PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
RL Cell 99:335-345 (1999).
RN [2]; RE0030621.
RX PUBMED: 12606719.
RA Ziouzenkova O., Perrey S., Asatryan L., Hwang J., MacNaul K. L., Moller D. E., Rader D. J., Sevanian A., Zechner R., Hoefler G., Plutzky J.
RT Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase.
RL Proc. Natl. Acad. Sci. USA 100:2730-5 (2003).
RN [3]; RE0031339.
RX PUBMED: 12576510.
RA Hellemans K., Rombouts K., Quartier E., Dittie A. S., Knorr A., Michalik L., Rogiers V., Schuit F., Wahli W., Geerts A.
RT PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.
RL J. Lipid Res. 44:280-95 (2003).
RN [4]; RE0032479.
RX PUBMED: 11867749.
RA Shi Y., Hon M., Evans R. M.
RT The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.
RL Proc. Natl. Acad. Sci. USA 99:2613-8 (2002).
RN [5]; RE0033105.
RX PUBMED: 15001550.
RA Lim H. J., Moon I., Han K.
RT Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.
RL Endocrinology 145:2886-95 (2004).
RN [6]; RE0036975.
RX PUBMED: 11551955.
RA Hatae T., Wada M., Yokoyama C., Shimonishi M., Tanabe T.
RT Prostacyclin-dependent apoptosis mediated by PPAR delta
RL J. Biol. Chem. 276:46260-7 (2001).
RN [7]; RE0041806.
RX PUBMED: 15126355.
RA Stephen R. L., Gustafsson M. C., Jarvis M., Tatoud R., Marshall B. R., Knight D., Ehrenborg E., Harris A. L., Wolf C. R., Palmer C. N.
RT Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines
RL Cancer Res. 64:3162-70 (2004).
RN [8]; RE0042672.
RX PUBMED: 12118038.
RA Muoio D. M., MacLean P. S., Lang D. B., Li S., Houmard J. A., Way J. M., Winegar D. A., Corton J. C., Dohm G. L., Kraus W. E.
RT Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
RL J. Biol. Chem. 277:26089-97 (2002).
RN [9]; RE0042675.
RX PUBMED: 12036946.
RA Shao J., Sheng H., DuBois R. N.
RT Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells
RL Cancer Res. 62:3282-8 (2002).
RN [10]; RE0042706.
RX PUBMED: 11564673.
RA Son C., Hosoda K., Matsuda J., Fujikura J., Yonemitsu S., Iwakura H., Masuzaki H., Ogawa Y., Hayashi T., Itoh H., Nishimura H., Inoue G., Yoshimasa Y., Yamori Y., Nakao K.
RT Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes
RL Endocrinology 142:4189-94 (2001).
RN [11]; RE0042712.
RX PUBMED: 10634806.
RA Sartippour M. R., Renier G.
RT Differential regulation of macrophage peroxisome proliferator-activated receptor expression by glucose : role of peroxisome proliferator-activated receptors in lipoprotein lipase gene expression
RL Arterioscler. Thromb. Vasc. Biol. 20:104-10 (2000).
RN [12]; RE0042716.
RX PUBMED: 12077340.
RA Tan N. S., Shaw N. S., Vinckenbosch N., Liu P., Yasmin R., Desvergne B., Wahli W., Noy N.
RT Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription
RL Mol. Cell. Biol. 22:5114-27 (2002).
RN [13]; RE0042762.
RX PUBMED: 11069900.
RA Hansen J. B., Zhang H., Rasmussen T. H., Petersen R. K., Flindt E. N., Kristiansen K.
RT Peroxisome proliferator-activated receptor delta (PPARdelta )-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling
RL J. Biol. Chem. 276:3175-82 (2001).
RN [14]; RE0050003.
RX PUBMED: 12909723.
RA Shureiqi I., Jiang W., Zuo X., Wu Y., Stimmel J. B., Leesnitzer L. M., Morris J. S., Fan H. Z., Fischer S. M., Lippman S. M.
RT The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
RL Proc. Natl. Acad. Sci. USA 100:9968-9973 (2003).
RN [15]; RE0050013.
RX PUBMED: 16288226.
RA Zuo X., Wu Y., Morris J. S., Stimmel J. B., Leesnitzer L. M., Fischer S. M., Lippman S. M., Shureiqi I.
RT Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity.
RL Oncogene 25:1225-1241 (2006).
RN [16]; RE0050025.
RX PUBMED: 10198642.
RA Xu H. E., Lambert M. H., Montana V. G., Parks D. J., Blanchard S. G., Brown P. J., Sternbach D. D., Lehmann J. M., Wisely G. B., Willson T. M., Kliewer S. A., Milburn M. V.
RT Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
RL Mol. Cell 3:397-403 (1999).
RN [17]; RE0050145.
RX PUBMED: 12963727.
RA Shaw N., Elholm M., Noy N.
RT Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta.
RL J. Biol. Chem. 278:41589-41592 (2003).
RN [18]; RE0050245.
RX PUBMED: 17092771.
RA Liliom K., Tsukahara T., Tsukahara R., Zelman-Femiak M., Swiezewska E., Tigyi G.
RT Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs.
RL Biochim. Biophys. Acta 1761:1506-1514 (2006).
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