AC T04684
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ID T04684
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DT 27.08.2001 (created); rio.
DT 17.12.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA STAT5B
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SY signal transducer and activator of transcription 5b; STAT5B.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002607 STAT5B; HGNC: STAT5B.
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CL C0039; STAT; 6.2.1.0.6.
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CP HepG2 cells under hypoxia (2% oxygen) [12].
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FF induction of tyrosine phosphorylation of STAT5 by thrombopoietin (TPO) in CMK cells [2];
FF needs to be Tyr-phosphorylated and activated by Hck and Abl for binding to the Fc gamma RI promoter [5];
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IN T18888 DMRT4; human, Homo sapiens.
IN T34781 ErbB1; human, Homo sapiens.
IN T00641 POU2F1-isoform1; human, Homo sapiens.
IN T04684 STAT5B; human, Homo sapiens.
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MX M00459 V$STAT5B_01.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
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BS R14236.
BS R15672.
BS R15838.
BS R12435.
BS R12436.
BS R14310.
BS R14311.
BS R26866.
BS R30840.
BS R40251.
BS R24153.
BS R11154.
BS R72060.
BS R34976.
BS R13215.
BS R65325.
BS R16930.
BS R13241.
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DR TRANSPATH: MO000013132.
DR TRANSCOMPEL: C00424.
DR TRANSCOMPEL: C00610.
DR TRANSCOMPEL: C00640.
DR UniProtKB: P51692;
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RN [1]; RE0016782.
RX PUBMED: 10594041.
RA Soldaini E., John S., Moro S., Bollenbacher J., Schindler U., Leonard W. J.
RT DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.
RL Mol. Cell. Biol. 20:389-401 (2000).
RN [2]; RE0017746.
RX PUBMED: 9111365.
RA Matsumura I., Ishikawa J., Nakajima K., Oritani K., Tomiyama Y., Miyagawa J., Kato T., Miyazaki H., Matsuzawa Y., Kanakura Y.
RT Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5.
RL Mol. Cell. Biol. 17:2933-2943 (1997).
RN [3]; RE0019123.
RX PUBMED: 8732682.
RA SILVA C.M., LU H., DAY R.N.
RT Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.
RL Mol. Endocrinol. 10:508-518 (1996).
RN [4]; RE0019124.
RX PUBMED: 8631883.
RA LIN J.X., MIETZ J., MODI W.S., JOHN S., LEONARD W.J.
RT Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.
RL J. Biol. Chem. 271:10738-10744 (1996).
RN [5]; RE0023476.
RX PUBMED: 12411494.
RA Klejman A., Schreiner S. J., Nieborowska-Skorska M., Slupianek A., Wilson M., Smithgall T. E., Skorski T.
RT The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.
RL EMBO J. 21:5766-5774 (2002).
RN [6]; RE0027727.
RX PUBMED: 10558875.
RA Runge D. M., Runge D., Foth H., Strom S. C., Michalopoulos G. K.
RT STAT 1alpha/1beta, STAT 3 and STAT 5: expression and association with c-MET and EGF-receptor in long-term cultures of human hepatocytes.
RL Biochem. Biophys. Res. Commun. 265:376-81 (1999).
RN [7]; RE0028648.
RX PUBMED: 11038252.
RA Halfter H., Postert C., Friedrich M., Ringelstein E. B., Stogbauer F.
RT Activation of the Jak-Stat- and MAPK-pathways by oncostatin M is not sufficient to cause growth inhibition of human glioma cells.
RL Brain Res. Mol. Brain Res. 80:198-206 (2000).
RN [8]; RE0032828.
RX PUBMED: 11801527.
RA Miscia S., Marchisio M., Grilli A., Di Valerio V., Centurione L., Sabatino G., Garaci F., Zauli G., Bonvini E., Di Baldassarre A.
RT Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells.
RL Cell Growth Differ. 13:13-8 (2002).
RN [9]; RE0041903.
RX PUBMED: 9422769.
RA Al-Shami A., Mahanna W., Naccache P. H.
RT Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b
RL J. Biol. Chem. 273:1058-63 (1998).
RN [10]; RE0042419.
RX PUBMED: 12429742.
RA Kloth M. T., Laughlin K. K., Biscardi J. S., Boerner J. L., Parsons S. J., Silva C. M.
RT STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor
RL J. Biol. Chem. 278:1671-9 (2003).
RN [11]; RE0048233.
RX PUBMED: 11480573.
RA Quentmeier H., Drexler H. G., Fleckenstein D., Zaborski M., Armstrong A., Sims J. E., Lyman S. D.
RT Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation.
RL Leukemia 15:1286-1292 (2001).
RN [12]; RE0050497.
RX PUBMED: 17509524.
RA Joung Y. H., Lee M. Y., Lim E. J., Kim M. S., Hwang T. S., Kim S. Y., Ye S. K., Lee J. D., Park T., Woo Y. S., Chung I. M., Yang Y. M.
RT Hypoxia activates the IGF-1 expression through STAT5b in human HepG2 cells.
RL Biochem. Biophys. Res. Commun. 358:733-738 (2007).
RN [13]; RE0050848.
RX PUBMED: 12771142.
RA Xi S., Zhang Q., Dyer K. F., Lerner E. C., Smithgall T. E., Gooding W. E., Kamens J., Grandis J. R.
RT Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck.
RL J. Biol. Chem. 278:31574-31583 (2003).
RN [14]; RE0050972.
RX PUBMED: 16155412.
RA Joung Y. H., Lim E. J., Lee M. Y., Park J. H., Ye S. K., Park E. U., Kim S. Y., Zhang Z., Lee K. J., Park D. K., Park T., Moon W. K., Yang Y. M.
RT Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells.
RL Exp. Mol. Med. 37:353-364 (2005).
RN [15]; RE0052771.
RX PUBMED: 11867689.
RA Lehtonen A., Matikainen S., Miettinen M., Julkunen I.
RT Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.
RL J. Leukoc. Biol. 71:511-519 (2002).
RN [16]; RE0055268.
RX PUBMED: 17550976.
RA Neilson L. M., Zhu J., Xie J., Malabarba M. G., Sakamoto K., Wagner K. U., Kirken R. A., Rui H.
RT Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
RL Mol. Endocrinol. 21:2218-2232 (2007).
RN [17]; RE0055547.
RX PUBMED: 11032019.
RA Llovera M., Pichard C., Bernichtein S., Jeay S., Touraine P., Kelly P. A., Goffin V.
RT Human prolactin (hPRL) antagonists inhibit hPRL-activated signaling pathways involved in breast cancer cell proliferation.
RL Oncogene 19:4695-4705 (2000).
RN [18]; RE0055797.
RX PUBMED: 16772534.
RA Weaver A. M., Silva C. M.
RT Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain.
RL Mol. Endocrinol. 20:2392-2405 (2006).
RN [19]; RE0056116.
RX PUBMED: 15976008.
RA Boerner J. L., Gibson M. A., Fox E. M., Posner E. D., Parsons S. J., Silva C. M., Shupnik M. A.
RT Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells.
RL Mol. Endocrinol. 19:2660-2670 (2005).
RN [20]; RE0065425.
RX PUBMED: 19632985.
RA Dumoutier L., de Meester C., Tavernier J., Renauld J. C.
RT New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain.
RL J. Biol. Chem. 284:26377-26384 (2009).
RN [21]; RE0066428.
RX PUBMED: 9257712.
RA van Dijk T. B., Caldenhoven E., Raaijmakers J. A., Lammers J. W., Koenderman L., de Groot R. P.
RT Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5.
RL FEBS Lett. 412:161-164 (1997).
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