AC T02141
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ID T02141
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DT 23.05.1997 (created); hiwi.
DT 22.09.2011 (updated); grs.
CO Copyright (C), QIAGEN.
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FA OCA-B
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SY B-cell Oct-binding protein 1; Bob1; OBF1; OCA-B; Oct coactivator from B cells; POU2AF1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003984 POU2AF1; HGNC: POU2AF1.
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SF proline-rich, some homology with TAF(II)250 [2] [4];
SF interacts with trans-activation and with POU domains of Oct-1 and Oct-2 [2] [4] [5];
SF makes contacts specifically in the POUs subdomain which are important for DNA-binding [6];
SF the Oct/OCA-B complex exhibits a different and more stringent DNA-binding specificity than the isolated Oct-factors: the ternary complex requires an A at the fifth position of the canonical octamer motif ATGCAAAT [6] [7];
SF in these complexes, OCA-B forms additional major groove contacts between the two POU subdomains [7];
SF no interaction with N-Oct-3 or N-Oct-2 [2];
SF no interaction with Oct-4 or Oct-6 [4];
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CP spleen, peripheral blood leukocytes, very low in small intestine, thymus [2] [4].
CN colon, ovary, prostate, testis [2] [4].
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FF coactivator, augmenting the activity of Oct-1 and, less, of Oct-2 [2];
FF no DNA-binding activity by the isolated factor [2] [4];
FF because of its cell-specificity, it has been suggested to make Oct-1 a cell-specific factor [2];
FF acting promoter-specifically in stimulating Oct-dependent transcription from the immunoglobulin, but not from the histone H2B promoter [3];
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IN T00647 Oct-2; human, Homo sapiens.
IN T00641 POU2F1-isoform1; human, Homo sapiens.
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MX M02113 V$OCAB_Q6.
MX M00795 V$OCT_Q6.
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BS R31088.
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DR TRANSPATH: MO000026191.
DR UniProtKB: Q16633;
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RN [1]; RE0000370.
RX PUBMED: 2328728.
RA Mueller-Immerglueck M. M., Schaffner W., Matthias P.
RT Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells
RL EMBO J. 9:1625-1634 (1990).
RN [2]; RE0004283.
RX PUBMED: 7779176.
RA Gstaiger M., Knoepfel L., Georgiev O., Schaffner W., Hovens C. M.
RT A B-cell coactivator of octamer-binding transcription factors
RL Nature 373:360-362 (1995).
RN [3]; RE0004399.
RX PUBMED: 1423591.
RA Luo Y., Fujii H., Gerster T., Roeder R. G.
RT A novel B cell-derived coactivator potentiates the activation of immunoglogulin promoters by octamer-binding transcription
RL Cell 71:231-241 (1992).
RN [4]; RE0004442.
RX PUBMED: 7859290.
RA Strubin M., Newell J. W., Matthias P.
RT OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins
RL Cell 80:497-506 (1995).
RN [5]; RE0005624.
RX PUBMED: 7623806.
RA Luo Y., Roeder R. G.
RT Cloning, functional charcterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B
RL Mol. Cell. Biol. 15:4115-4124 (1995).
RN [6]; RE0005625.
RX PUBMED: 8654375.
RA Gstaiger M., Georgiev O., van Leeuwen H., an der Vliet P., Schaffner W.
RT The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation
RL EMBO J. 15:2781-2790 (1996).
RN [7]; RE0005626.
RX PUBMED: 8769650.
RA Cepek K. L., Chasman D. I., Sharp P. A.
RT Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B
RL Genes Dev. 10:2079-2088 (1996).
RN [8]; RE0066536.
RX PUBMED: 16186795.
RA Heckman C. A., Duan H., Garcia P. B., Boxer L. M.
RT Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression.
RL Oncogene 25:888-898 (2006).
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