AC T01578
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ID T01578
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DT 24.11.1995 (created); ewi.
DT 12.10.2009 (updated); mku.
CO Copyright (C), QIAGEN.
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FA STAT5A
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SY mammary gland factor; MGF; MPF; signal Transducer and Activator of Transcription 5; signal transducer and activator of transcription 5 A; signal transducer and activator of transcription 5A; STAT5A; STF-IL-3.
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OS sheep, Ovis aries
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; artiodactyla; ruminantia; pecora; bovidae
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GE G037510 STAT5A.
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CL C0039; STAT; 6.2.1.0.5.
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SF Oct-1 binding motif is conserved in several different proteins, STAT5A, OBF-1, SNAP190 [6];
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CP high in lactating mammary gland [2] [4] [1].
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FF mediates response to several cytokines and hormones, in particular to prolactin [2] [4] [1];
FF phosphorylation of Tyr-694 most likely by Jak2 [4];
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IN T00641 POU2F1-isoform1; human, Homo sapiens.
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MX M00457 V$STAT5A_01.
MX M00460 V$STAT5A_02.
MX M00493 V$STAT5A_03.
MX M00499 V$STAT5A_04.
MX M07311 V$STAT5A_Q4.
MX M01890 V$STAT5A_Q6.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
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BS R74046.
BS R04917.
BS R04650.
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DR TRANSPATH: MO000013129.
DR TRANSCOMPEL: C00011.
DR TRANSCOMPEL: C00303.
DR UniProtKB: P42231;
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RN [1]; RE0002516.
RX PUBMED: 1557422.
RA Schmitt-Ney M., Happ B., Ball R. K., Groner B.
RT Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein
RL Proc. Natl. Acad. Sci. USA 89:3130-3134 (1992).
RN [2]; RE0003484.
RX PUBMED: 7514531.
RA Wakao H., Gouilleux F., Groner B.
RT Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
RL EMBO J. 13:2182-2191 (1994).
RN [3]; RE0003485.
RX PUBMED: 7537213.
RA Azam M., Erdjument-Bromage H., Kreider B. L., Xia M., Quelle F., Basu R., Saris C., Tempst P., Ihle J. N., Schindler C.
RT Interleukin-3 signals through multiple isoforms of Stat5
RL EMBO J. 14:1402-1411 (1995).
RN [4]; RE0003515.
RX PUBMED: 7925280.
RA Gouilleux F., Wakao H., Mundt M., Groner B.
RT Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
RL EMBO J. 13:4361-4369 (1994).
RN [5]; RE0019122.
RX PUBMED: 7882987.
RA WAKAO H., GOUILLEUX F., GRONER B.
RT Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
RL EMBO J. 14:854-855 (1995).
RN [6]; RE0024933.
RX PUBMED: 14645506.
RA Magne S., Caron S., Charon M., Rouyez M. C., Dusanter-Fourt I.
RT STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression.
RL Mol. Cell. Biol. 23:8934-8945 (2003).
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