AC T00923
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ID T00923
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DT 15.10.1992 (created); ewi.
DT 12.08.2011 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Zta
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SY BZLF1; EB1; Z protein; ZEBRA; Zta.
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OS EBV, Epstein-Barr virus
OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae
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CL C0008; bZIP.
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SZ 245 AA; 26.9 kDa (gene) (calc.).
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SQ MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQ
SQ LTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAPQPGDNS
SQ TVQTAAAVVFACPGANQGQQLADIGVPQPAPVAAPARRTRKPQQPESLEECDSELEIKRY
SQ KNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHE
SQ DLLNF
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SC Swiss-Prot#P03206
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FT 170 231 
PF00170; bZIP transcription factor.
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SF DNA-binding by a Zta homodimer, bending towards the major groove [7];
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FF synergizes with R;
FF stabilizes TBP-binding through direct interaction;
FF also synergizes with c-Myb [6];
FF direct interaction inhibits trans-activation by p53 [8];
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IN T00671 p53; human, Homo sapiens.
IN T00794 TBP; human, Homo sapiens.
IN T00923 Zta; EBV, Epstein-Barr virus.
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MX M00711 V$ZTA_Q2.
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BS R03178.
BS R03179.
BS R03180.
BS R03181.
BS R04261.
BS R00196.
BS R03344.
BS R03345.
BS R36351.
BS R00295.
BS R00296.
BS R00297.
BS R00298.
BS R00299.
BS R00301.
BS R00302.
BS R36007.
BS R26551.
BS R26557.
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DR TRANSPATH: MO000002014.
DR EMBL: V01555;
DR UniProtKB: P03206;
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RN [1]; RE0000326.
RX PUBMED: 2540954.
RA Farrell P. J., Rowe D. T., Rooney C. M., Kouzarides T.
RT Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos
RL EMBO J. 8:127-132 (1989).
RN [2]; RE0000750.
RX PUBMED: 1661258.
RA Lieberman P. M., Berk A. J.
RT The Zta trans-activator protein stabilizes TFIID association with promoter DNA by direct protein-protein interaction
RL Genes Dev. 5:2441-2454 (1991).
RN [3]; RE0001170.
RX PUBMED: 1649314.
RA Taylor N., Flemington E., Kolman J. L., Baumann R. P., Speck S. H., Miller G.
RT ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein-Barr virus BZLF1 promoter
RL J. Virol. 65:4033-4041 (1991).
RN [4]; RE0001175.
RX PUBMED: 1851858.
RA Young L. S., Lau R., Rowe M., Niedobitek G., Packham G., Shanahan F., Rowe D. T., Greenspan D., Greenspan J. S., Rickinson A. B., Farrell P. J.
RT Differentiation-associated expression of the Epstein-Barr BZLF1 transactivator protein in oral hairy leukoplakia
RL J. Virol. 65:2868-2874 (1991).
RN [5]; RE0002145.
RX PUBMED: 1851554.
RA Giot F.-F., Mikaelian I., Buisson M., Manet E., Joab I., Nicolas J.-C., Sergeant A.
RT Transcriptional interference between the EBV transcription factors EB1 and R: both DNA-binding and activation domains of EB1 are required
RL Nucleic Acids Res. 19:1251-1258 (1991).
RN [6]; RE0003081.
RX PUBMED: 1309587.
RA Kenney S. C., Holley-Guthrie E., Quinlivan E. B., Gutsch D., Zhang Q., Bender T., Giot J.-F., Sergeant A.
RT The cellular oncogene c-myb can interact synergistically with the Epstein-Barr virus BZLF1 transactivator in lymphoid cells
RL Mol. Cell. Biol. 12:136-146 (1992).
RN [7]; RE0004643.
RX PUBMED: 8355695.
RA Kerppola T. K., Curran T.
RT Selective DNA bending by a variety of bZIP proteins
RL Mol. Cell. Biol. 13:5479-5489 (1993).
RN [8]; RE0004644.
RX PUBMED: 8114724.
RA Zhang Q., Gutsch D., Kenney S.
RT Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency
RL Mol. Cell. Biol. 14:1929-1938 (1994).
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