AC T02224
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ID T02224
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DT 24.10.1997 (created); ewi.
DT 08.06.2012 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA TFIIA-gamma
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SY general transcription factor IIA, 2, 12kDa; GTF2A2; TF2A2; TFIIA; TFIIA p12 subunit; TFIIA-12; TFIIA-gamma; TFIIA-S; TFIIAS; transcription initiation factor IIA gamma chain.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003995 GTF2A2; HGNC: GTF2A2.
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HO TFIIA-S (Drosophila), TOA2 (yeast).
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SF assembles active holo-TFIIA either with alpha/beta-precursor or with alpha and beta subunits by interacting with the alpha, but not with the beta moiety [2] [3];
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CP (HeLa).
EX adrenal gland (right and left),,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX amygdaloid body,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX aorta,,,adult; medium; gel shift (RNA); mRNA (poly-A); [7].
EX appendix,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX bone marrow,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX brain,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX brain,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX brain,,,fetal; very low; gel shift (RNA); mRNA (poly-A); [7].
EX caudate nucleus,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX cerebellum,,,adult; medium; gel shift (RNA); mRNA (poly-A); [7].
EX cerebral cortex of cerebral hemisphere,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX cerebral cortex,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX colon,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX colon,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX frontal lobe of medial and inferior surfaces,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX frontal lobe of superolateral face,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX heart,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX heart,,,adult; high; gel shift (RNA); mRNA (poly-A); [7].
EX heart,,,fetal; low; gel shift (RNA); mRNA (poly-A); [7].
EX hippocampus,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX kidney (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX kidney (right and left),,,adult; medium; gel shift (RNA); mRNA (poly-A); [7].
EX kidney (right and left),,,fetal; low; gel shift (RNA); mRNA (poly-A); [7].
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX liver,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX liver,,,fetal; low; gel shift (RNA); mRNA (poly-A); [7].
EX lung (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX lung (right and left),,,adult; medium; gel shift (RNA); mRNA (poly-A); [7].
EX lung (right and left),,,fetal; medium; gel shift (RNA); mRNA (poly-A); [7].
EX lymph node,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX major salivary glands,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX mammary gland,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX minor salivary glands,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX muscles,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX muscles,,,adult; high; gel shift (RNA); mRNA (poly-A); [7].
EX myelencephalon,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX nucleus accumbens,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX occipital lobe of medial and inferior surfaces,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX occipital lobe of superolateral face,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX ovary (right and left),,,adult; medium; gel shift (RNA); mRNA (poly-A); [7].
EX pancreas,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX pancreas,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX pituitary gland of diencephalon,,,adult; high; gel shift (RNA); mRNA (poly-A); [7].
EX placenta,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX placenta,,,adult; high; gel shift (RNA); mRNA (poly-A); [7].
EX prostate gland,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX prostate gland,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX putamen,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX small intestine,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX small intestine,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX spinal cord,,,adult; medium; gel shift (RNA); mRNA (poly-A); [7].
EX spleen,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX spleen,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX spleen,,,fetal; low; gel shift (RNA); mRNA (poly-A); [7].
EX stomach,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX substantia nigra,,,adult; medium; gel shift (RNA); mRNA (poly-A); [7].
EX temporal lobe of medial and inferior surfaces,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX temporal lobe of superolateral face,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX testis (right and left),,,adult; high; Northern blot; mRNA (poly-A); [7].
EX testis (right and left),,,adult; very high; gel shift (RNA); mRNA (poly-A); [7].
EX thalamus,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX thymus,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX thymus,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX thymus,,,fetal; low; gel shift (RNA); mRNA (poly-A); [7].
EX thyroid gland,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX trachea,,,adult; medium; gel shift (RNA); mRNA (poly-A); [7].
EX tubular salivary gland,,,adult; low; gel shift (RNA); mRNA (poly-A); [7].
EX urinary bladder,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
EX uterus,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX uterus,,,adult; very low; gel shift (RNA); mRNA (poly-A); [7].
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IN T00794 TBP; human, Homo sapiens.
IN T10643 TBPL1; human, Homo sapiens.
IN T02216 TFIIA-alpha/beta precursor (major); human, Homo sapiens.
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MX M00707 V$TFIIA_Q6.
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BS R00996.
BS R01002.
BS R01015.
BS R01016.
BS R01017.
BS R01018.
BS R01605.
BS R39032.
BS R03170.
BS R00705.
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DR TRANSPATH: MO000013252.
DR UniProtKB: P52657;
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RN [1]; RE0005655.
RX PUBMED: 1729613.
RA Cortes P., Flores O., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II: Purification and analysis of transcription factor IIA and identification of transcription factor IIJ
RL Mol. Cell. Biol. 12:413-421 (1992).
RN [2]; RE0005656.
RX PUBMED: 7958899.
RA Ozer J., Moore P. A., Bolden A. H., Lee A., Rosen C. A., Lieberman P. M.
RT Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription
RL Genes Dev. 8:2324-2335 (1994).
RN [3]; RE0005657.
RX PUBMED: 7958900.
RA Sun X., Ma D., Sheldon M., Yeung K., Reinberg D.
RT Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription
RL Genes Dev. 8:2336-2348 (1994).
RN [4]; RE0005658.
RX PUBMED: 8224850.
RA Ma D., Watanabe H., Mermelstein F., Admon A., Oguri K., Sun X., Wada T., Imai T., Shiroya T., Reinberg D., Handa H.
RT Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription
RL Genes Dev. 7:2246-2257 (1993).
RN [5]; RE0005659.
RX PUBMED: 8224848.
RA Dejong J., Roeder R. G.
RT A single cDNA hTFIIA/alpha encodes both the p35 and p19 subunits of human TFIIA
RL Genes Dev. 7:2220-2234 (1993).
RN [6]; RE0005663.
RX PUBMED: 7724559.
RA Dejong J., Bernstein R., Roeder R. G.
RT Human general transcription factor TFIIA: Characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription
RL Proc. Natl. Acad. Sci. USA 92:3313-3317 (1995).
RN [7]; RE0017409.
RX PUBMED: 10364255.
RA Upadhyaya A. B., Lee S. H., Dejong J.
RT Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis
RL J. Biol. Chem. 274:18040-18048 (1999).
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