AC T00559
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ID T00559
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DT 15.10.1992 (created); ewi.
DT 25.11.2010 (updated); din.
CO Copyright (C), QIAGEN.
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FA NF-E3
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SY NF-E3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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SF nuclear activity in erythroid cells [1];
SF a part of NF-E3 complex has been identified as nuclear receptor COUP-TF2 T00045 [2] [3];
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FF is an important regulator of embryonic to fetal globin gene switching [2] [3];
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BS R01859.
BS R16621.
BS R16624.
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DR TRANSPATH: MO000025013.
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RN [1]; RE0002047.
RX PUBMED: 2476717.
RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S.
RT The deletion of the distal CCAAT box region of the Agamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein
RL Nucleic Acids Res. 17:6681-6691 (1989).
RN [2]; RE0035108.
RX PUBMED: 11544252.
RA Liberati C., Cera M. R., Secco P., Santoro C., Mantovani R., Ottolenghi S., Ronchi A.
RT Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters.
RL J. Biol. Chem. 276:41700-41709 (2001).
RN [3]; RE0035110.
RX PUBMED: 9927428.
RA Filipe A., Li Q., Deveaux S., Godin I., Romeo P. H., Stamatoyannopoulos G., Mignotte V.
RT Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching.
RL EMBO J. 18:687-697 (1999).
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