AC T19630
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ID T19630
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DT 06.12.1999 (created); ili.
DT 07.11.2014 (updated); asv.
CO Copyright (C), QIAGEN.
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FA Ku autoantigen
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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SF subunit of DNA-PK [2];
SF by itself a heterodimer composed of a p70 and a p86 subunit [1];
SF ribosylated by PARP [2];
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CP SK-BR3 [1].
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FF subunit of DNA-dependent protein kinase and by itself a heterodimer [1];
FF known to bind to free ends of DNA [1];
FF may also bind to DNA in sequence-dependent manner [1];
FF concluded to recognize the primary sequence of base unpairing regions [1];
FF binds also to the IgH enhancer at elevated concentrations [1];
FF ADP-ribosylation circumvents binding to base unpairing regions [1];
FF physical interaction with PARP in vivo is independent of the presence of DNA and critical for synergistic binding to S/MARs [1];
FF involved in chromosome condensation [2];
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IN T14055 PARP; human, Homo sapiens.
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BS R33749.
BS R33750.
BS R33765.
BS R33773.
BS R33774.
BS R64781.
BS R64769.
BS R35856.
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DR TRANSPATH: MO000056113.
DR SMARTDB: SB000054.
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RN [1]; RE0013868.
RX PUBMED: 10400681.
RA Galande S., Kohwi-Shigematsu T.
RT Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences
RL J. Biol. Chem. 274:20521-20528 (1999).
RN [2]; RE0014969.
RX PUBMED: 10813395.
RA Galande S., Kohwi-Shigematsu T.
RT Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction
RL Crit. Rev. Eukaryot. Gene Expr. 10:63-72 (2000).
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