AC T08912
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ID T08912
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DT 14.06.2005 (created); oke.
DT 14.08.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA SREBP-1
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SY bHLHd1; Class D basic helix-loop-helix protein 1; SREBF1; SREBP-1; SREBP-1c; SREBP1; Sterol Regulatory Element Binding Protein 1; sterol regulatory element binding transcription factor 1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003956 SREBF1; HGNC: SREBF1.
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CL C0012; bHLH-ZIP; 1.2.6.3.1.
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FF between SREBP-1 and IRS-2 expression exist an inverse correlation, so that SREBP-1 might regulate IRS-2 gene expression [4];
FF The binding to E-Box sequence is increased in the presence of SFM [1];
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MX M04741 V$SREBF1_02.
MX M07405 V$SREBF1_03.
MX M00220 V$SREBP1_01.
MX M00221 V$SREBP1_02.
MX M01173 V$SREBP1_Q5.
MX M00749 V$SREBP1_Q6.
MX M04632 V$SREBP1_Q6_01.
MX M00776 V$SREBP_Q3.
MX M01168 V$SREBP_Q6.
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BS R21208.
BS R19467.
BS R69243.
BS R71223.
BS R71224.
BS R71225.
BS R71226.
BS R67171.
BS R19293.
BS R22482.
BS R26039.
BS R65429.
BS R67177.
BS R67180.
BS R21578.
BS R67179.
BS R31441.
BS R21206.
BS R30370.
BS R28319.
BS R31277.
BS R41721.
BS R41725.
BS R59476.
BS R67182.
BS R70319.
BS R67184.
BS R67185.
BS R28242.
BS R21339.
BS R67176.
BS R67178.
BS R21199.
BS R21200.
BS R21202.
BS R21204.
BS R21205.
BS R19452.
BS R38736.
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DR TRANSPATH: MO000056029.
DR TRANSCOMPEL: C00204.
DR TRANSCOMPEL: C00205.
DR UniProtKB: P36956; SRE1_HUMAN.
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RN [1]; RE0049689.
RX PUBMED: 15358760.
RA Zeng L., Liao H., Liu Y., Lee T. S., Zhu M., Wang X., Stemerman M. B., Zhu Y., Shyy J. Y.
RT Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.
RL J. Biol. Chem. 279:48801-48807 (2004).
RN [2]; RE0070393.
RX PUBMED: 16251441.
RA Valenza M., Rigamonti D., Goffredo D., Zuccato C., Fenu S., Jamot L., Strand A., Tarditi A., Woodman B., Racchi M., Mariotti C., Di Donato S., Corsini A., Bates G., Pruss R., Olson J. M., Sipione S., Tartari M., Cattaneo E.
RT Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.
RL J. Neurosci. 25:9932-9939 (2005).
RN [3]; RE0072520.
RX PUBMED: 16825193.
RA Punga T., Bengoechea-Alonso M. T., Ericsson J.
RT Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.
RL J. Biol. Chem. 281:25278-25286 (2006).
RN [4]; RE0047892.
RX PUBMED: 15048126.
RA Ide T., Shimano H., Yahagi N., Matsuzaka T., Nakakuki M., Yamamoto T., Nakagawa Y., Takahashi A., Suzuki H., Sone H., Toyoshima H., Fukamizu A., Yamada N.
RT SREBPs suppress IRS-2-mediated insulin signalling in the liver.
RL Nat. Cell Biol. 6:351-357 (2004).
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