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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T09150 XX ID T09150 XX DT 31.07.2006 (created); res. DT 11.01.2016 (updated); sla. CO Copyright (C), QIAGEN. XX FA pax-6-isoform1 XX SY mPax-6; mPax6; Pax-6; PAX6; pax6-isoform1; Sey; Small eye. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G009200 Pax6. XX CL C0018; paired-homeo; 3.2.1.2.2.1. XX SZ 422 AA; 46.7 kDa (cDNA) (calc.). XX SQ MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRY SQ YETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV SQ SSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQ SQ EGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFAR SQ ERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIP SQ QPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPT SQ SPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPR SQ LQ XX SC Swiss-Prot#P63015-1 XX FT 4 128 PF00292; 'Paired box' domain. FT 4 128 SM00351; pax3. FT 4 130 PS51057; PAIRED_2. FT 57 415 PF00478; IMP dehydrogenase / GMP reductase domain. FT 208 268 PS50071; HOMEOBOX_2. FT 210 266 PS50552; PAX. FT 210 272 SM00389; HOX_1. FT 211 267 PF00046; Homeobox domain. XX IN T01427 p300; human, Homo sapiens. XX MX M00097 V$PAX6_01. MX M01391 V$PAX6_02. MX M00979 V$PAX6_Q2. MX M00808 V$PAX_Q6. XX BS R03013. BS R08833. BS R08828. BS R08840. BS R08838. BS R08836. BS R08529. BS R08530. BS R08532. BS R08831. BS R08832. BS R08827. BS R08837. BS R08834. BS R08829. BS R08839. BS R00582. BS R08703. BS R08777. BS R20688. BS R08830. BS R08705. BS R08826. BS R08835. BS R08706. BS R08825. XX DR TRANSPATH: MO000083905. DR EMBL: X63963; DR EMBL: X82150; DR UniProtKB: P63015-1; XX RN [1]; RE0002821. RX PUBMED: 1684639. RA Hill R. E., Favor J., Hogan B. L. M., Ton C. C. T., Saunders G. F., Hanson I. M., Prosser J., Jordan T., Hastie N. D., van Heyningen V. RT Mouse Small eye results from mutations in a paired-like homeobox-containing gene RL Nature 354:522-525 (1991). RN [2]; RE0004257. RX PUBMED: 1685142. RA Walther C., Guenet J. L., Simon D., Deutsch U., Jostes B., Goulding M. D., Plachov D., Balling R., Gruss P. RT Pax: a murine multigene family of paired box-containing genes RL Genomics 11:424-434 (1991). RN [3]; RE0004258. RX PUBMED: 1687460. RA Walther C., Gruss P. RT Pax-6, a murine paired box gene, is expressed in the developing CNS RL Development 113:1435-1449 (1991). RN [4]; RE0006040. RX PUBMED: 9224716. RA Sander M., Neubueser A., Kalamaras J., Ee H. C., Martin G. R., German M. S. RT Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development RL Genes Dev. 11:1662-1673 (1997). RN [5]; RE0006130. RX PUBMED: 9163426. RA St-Onge L., Sosa-Pineda B., Chowdhury K., Mansouri A., Gruss P. RT Pax6 is required for differentiation of glucagon-producing alpha -cells in mouse pancreas RL Nature 387:406-409 (1997). RN [6]; RE0011033. RX PUBMED: 7753863. RA Richardson J., Cvekl A., Wistow G. RT Pax-6 is essential for lens-specific expression of zeta-crystallin RL Proc. Natl. Acad. Sci. USA 92:4676-4680 (1995). RN [7]; RE0012625. RX PUBMED: 8600027. RA Quinn J. C., West J. D., Hill R. E. RT Multiple functions for Pax6 in mouse eye and nasal development RL Genes Dev. 10:435-446 (1996). RN [8]; RE0012695. RX PUBMED: 8689689. RA Schedl A., Ross A., Lee M., Engelkamp D., Rashbass P., van Heyningen V., Hastie N. D. RT Influence of PAX6 gene dosage on development: overexpression causes sevre eye abnormalities RL Cell 86:71-82 (1996). RN [9]; RE0013854. RX PUBMED: 10478839. RA Hill M. E., Asa S. L., Drucker D. J. RT Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription RL Mol. Endocrinol. 13:1474-1486 (1999). RN [10]; RE0014020. RX PUBMED: 7917011. RA Chalepakis G., Wijnholds J., Giese P., Schachner M., Gruss P. RT Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1 RL DNA Cell Biol. 13:891-900 (1994). RN [11]; RE0014123. RX PUBMED: 10567553. RA Fujitani Y., Kajimoto Y., Yasuda T., Matsuoka T. A., Kaneto H., Umayahara Y., Fujita N., Watada H., Miyazaki J. I., Yamasaki Y., Hori M. RT Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas RL Mol. Cell. Biol. 19:8281-8291 (1999). RN [12]; RE0014138. RX PUBMED: 10567552. RA Smith S. B., Ee H. C., Conners J. R., German M. S. RT Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development RL Mol. Cell. Biol. 19:8272-8280 (1999). RN [13]; RE0014292. RX PUBMED: 10717483. RA Zhou Y., Zheng J. B., Gu X., Li W., Saunders G. F. RT A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements RL Gene 245:319-328 (2000). RN [14]; RE0014449. RX PUBMED: 9636075. RA Hallonet M., Hollemann T., Wehr R., Jenkins N. A., Copeland N. G., Pieler T., Gruss P. RT Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain RL Development 125:2599-2610 (1998). RN [15]; RE0062609. RX PUBMED: 16115881. RA Grinchuk O., Kozmik Z., Wu X., Tomarev S. RT The Optimedin gene is a downstream target of Pax6. RL J. Biol. Chem. 280:35228-35237 (2005). RN [16]; RE0062650. RX PUBMED: 16407227. RA Kim E. A., Noh Y. T., Ryu M. J., Kim H. T., Lee S. E., Kim C. H., Lee C., Kim Y. H., Choi C. Y. RT Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. RL J. Biol. Chem. 281:7489-7497 (2006). XX //