AC T09154
XX
ID T09154
XX
DT 31.07.2006 (created); ran.
DT 03.06.2013 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA SRC3
XX
SY NCOA-3; NCOA3; nuclear receptor coactivator 3; p/CIP; P300/CBP/co-integrator protein; SRC-3; steroid receptor coactivator-3.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002756 Ncoa3.
XX
CL C0010; bHLH.
XX
SZ 1398 AA; 151.6 kDa (cDNA) (calc.).
XX
SQ MSGLGESSLDPLAAESRKRKLPCDAPGQGLVYSGEKWRREQESKYIEELAELISANLSDI
SQ DNFNVKPDKCAILKETVRQIRQIKEQGKTISSDDDVQKADVSSTGQGVIDKDSLGPLLLQ
SQ ALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYSILHEPRRKDFLNTYQNPQLM
SQ EFLGLMRTRDKKAPYILIVRMLMKTHDILEDVNASPETRQRYETMQCFALSQPRAMLEEG
SQ EDLQCCMICVARRVTAPFPSSPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQ
SQ RFFSLNDGQSWSQKRHYQEAYVHGHAETPVYRFSLADGTIVSAQTKSKLFRNPVTNDRHG
SQ FISTHFLQREQNGYRPNPIPQDKGIRPPAAGCGVSMSPNQNVQMMGSRTYGVPDPSNTGQ
SQ MGGARYGASSSVASLTPGQSLQSPSSYQNSSYGLSMSSPPHGSPGLGPNQQNIMISPRNR
SQ GSPKMASHQFSPAAGAHSPMGPSGNTGSHSFSSSSLSALQAISEGVGTSLLSTLSSPGPK
SQ LDNSPNMNISQPSKVSGQDSKSPLGLYCEQNPVESSVCQSNSRDPQVKKESKESSGEVSE
SQ TPRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDPNCKDSSVSVTSPSGVSSSTSGTV
SQ SSTSNVHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSTASCGEGTTRQEQLS
SQ PKKKENNALLRYLLDRDDPSDVLAKELQPQADSGDSKLSQCSCSTNPSSGQEKDPKIKTE
SQ TNDEVSGDLDNLDAILGDLTSSDFYNNPTNGGHPGAKQQMFAGPSSLGLRSPQPVQSVRP
SQ PYNRAVSLDSPVSVGSGPPVKNVSAFPGLPKQPILAGNPRMMDSQENYGANMGPNRNVPV
SQ NPTSSPGDWGLANSRASRMEPLASSPLGRTGADYSATLPRPAMGGSVPTLPLRSNRLPGA
SQ RPSLQQQQQQQQQQQQQQQQQQQQQQQMLQMRTGEIPMGMGVNPYSPAVQSNQPGSWPEG
SQ MLSMEQGPHGSQNRPLLRNSLDDLLGPPSNAEGQSDERALLDQLHTFLSNTDATGLEEID
SQ RALGIPELVNQGQALESKQDVFQGQEAAVMMDQKAALYGQTYPAQGPPLQGGFNLQGQSP
SQ SFNSMMGQISQQGSFPLQGMHPRAGLVRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALEM
SQ KMENPAGTAVMRPMMPQAFFNAQMAAQQKRELMSHHLQQQRMAMMMSQPQPQAFSPPPNV
SQ TASPSMDGVLAGSAMPQAPPQQFPYPANYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNA
SQ MVQHPQPTPMYQPSDMKGWPSGNLARNGSFPQQQFAPQGNPAAYNMVHMNSSGGHLGQMA
SQ MTPMPMSGMPMGPDQKYC
XX
SC translated from EMBL #AF000581
XX
FT 16 84 
PS50888; HLH.
FT 32 89 
SM00353; finulus.
FT 56 1235 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 113 179 
SM00091; pas_2.
FT 113 212 
PF00989; PAS fold.
FT 118 176 
PS50112; PAS.
FT 1265 1322 
PF07469; Domain of unknown function (DUF1518).
XX
IN T15118 CBP; Mammalia.
IN T09602 ER; Mammalia.
IN T08321 p53-isoform1; human, Homo sapiens.
XX
DR TRANSPATH: MO000083916.
DR EMBL: AF000581;
DR UniProtKB: O09000;
XX
RN [1]; RE0006908.
RX PUBMED: 9430642.
RA Voegel J. J., Heine M. J., Tini M., Vivat V., Chambon P., Gronemeyer H.
RT The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
RL EMBO J. 17:507-519 (1998).
RN [2]; RE0016476.
RX PUBMED: 10713439.
RA Leo C., Chen J. D.
RT The SRC family of nuclear receptor coactivators
RL Gene 245:1-11 (2000).
RN [3]; RE0048011.
RX PUBMED: 10551785.
RA Lee S. K., Kim H. J., Kim J. W., Lee J. W.
RT Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53.
RL Mol. Endocrinol. 13:1924-1933 (1999).
XX
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