AC T09222
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ID T09222
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DT 16.08.2006 (created); din.
DT 07.06.2010 (updated); ada.
CO Copyright (C), QIAGEN.
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FA CHX10
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SY C. elegans ceh-10 homeo domain containing homolog; C. elegans ceh-10 homeo domain-containing homolog; Chx10; Hox-10; HOX10; OR; RET1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005938 Vsx2.
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CL C0006; homeo.
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SZ 361 AA; 39.4 kDa (cDNA) (calc.), 39 kDa (SDS) [2]
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SQ MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGH
SQ LLAARSVLSPAGVGSMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQT
SQ ASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREM
SQ LAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSA
SQ KDGIMDSCAPWLLGMHKKSLEAAAESGRKPEVERQALPKLDKMEQEERAPEAQAAISQEE
SQ LRENSIAALRAKAQEHSTKVLGTVSGPDSLARNAEKPEEEDATEEDRPAEKLSPPQLEDM
SQ A
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SC translated from EMBL #L34808
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FT 32 39 
conserved octapeptide [4].
FT 86 328 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 146 206 
PS50071; HOMEOBOX_2.
FT 148 204 
PS50552; PAX.
FT 148 210 
SM00389; HOX_1.
FT 149 205 
PF00046; Homeobox domain.
FT 208 264 
CVC domain [4].
FT 299 319 
PF03826; OAR domain.
FT 302 316 
OAR domain [3].
FT 304 317 
PS50803; OAR.
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IN T00682 Pax-6; zebra fish, Brachydanio rerio.
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MX M00437 V$CHX10_01.
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DR TRANSPATH: MO000085057.
DR EMBL: L34808;
DR UniProtKB: Q61412;
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RN [1]; RE0014085.
RX PUBMED: 9464541.
RA Wiggan O., Taniguchi-Sidle A., Hamel P. A.
RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains
RL Oncogene 16:227-236 (1998).
RN [2]; RE0014097.
RX PUBMED: 7914735.
RA Liu I. S., Chen J. D., Ploder L., Vidgen D., van der Kooy D., Kalnins V. I., McInnes R. R.
RT Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer
RL Neuron 13:377-393 (1994).
RN [3]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
RN [4]; RE0015515.
RX PUBMED: 7789259.
RA Svendsen P. C., McGhee J. D.
RT The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye
RL Development 121:1253-1262 (1995).
RN [5]; RE0047970.
RX PUBMED: 11069920.
RA Mikkola I., Bruun J. A., Holm T., Johansen T.
RT Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins.
RL J. Biol. Chem. 276:4109-4118 (2001).
RN [6]; RE0050673.
RX PUBMED: 16236706.
RA Dorval K. M., Bobechko B. P., Fujieda H., Chen S., Zack D. J., Bremner R.
RT CHX10 targets a subset of photoreceptor genes.
RL J. Biol. Chem. 281:744-751 (2006).
RN [7]; RE0066993.
RX PUBMED: 19843539.
RA Reichman S., Kalathur R. K., Lambard S., Ait-Ali N., Yang Y., Lardenois A., Ripp R., Poch O., Zack D. J., Sahel J. A., Leveillard T.
RT The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.
RL Hum. Mol. Genet. 19:250-261 (2010).
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