AC T09230
XX
ID T09230
XX
DT 16.08.2006 (created); din.
DT 05.10.2015 (updated); sla.
CO Copyright (C), QIAGEN.
XX
FA Prep-1isoform1
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SY Pbx regulating protein 1; PBX/Knox1-related homeobox; Prep1; Prep1-isoform1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002132 PKNOX1; HGNC: PKNOX1.
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CL C0006; homeo; 3.1.4.5.1.1.
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SZ 436 AA; 47.5 kDa (cDNA) (calc.).
XX
SQ MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYR
SQ HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK
SQ AIQVLRIHLLELEKVNELCKDFCSRYIACLKTEMNSETLLSGEPGSPYSPVQSQQIQSAI
SQ TGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQ
SQ LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN
SQ LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPS
SQ ELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALA
SQ PAHISGLVLANSDSLQ
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SC translated from EMBL #Y13613
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FT 8 309 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 50 83 
HR1 domain [7].
FT 108 153 
HR2 domain [7].
FT 257 320 
PS50071; HOMEOBOX_2.
FT 259 324 
SM00389; HOX_1.
FT 260 319 
PF00046; Homeobox domain.
FT 268 280 
helix 1 [7].
FT 288 298 
helix 2 [7].
FT 303 318 
helix 3 [7].
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IN T00682 Pax-6; zebra fish, Brachydanio rerio.
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MX M07304 V$PBX_Q5.
MX M01459 V$PREP1_01.
MX M07464 V$PREP1_Q3.
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BS R09696.
BS R09700.
BS R08497.
BS R09699.
BS R12755.
BS R20301.
XX
DR TRANSPATH: MO000085074.
DR EMBL: AP001748;
DR EMBL: U68727;
DR EMBL: Y13613;
DR UniProtKB: P55347-1;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0015485.
RX PUBMED: 9143494.
RA Chen H., Rossier C., Nakamura Y., Lynn A., Chakravarti A., Antonarakis S. E.
RT Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3
RL Genomics 41:193-200 (1997).
RN [3]; RE0015486.
RX PUBMED: 9479508.
RA Berthelsen J., Viggiano L., Schulz H., Ferretti E., Consalez G. G., Rocchi M., Blasi F.
RT PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C
RL Genomics 47:323-324 (1998).
RN [4]; RE0015488.
RX PUBMED: 9482739.
RA Berthelsen J., Zappavigna V., Mavilio F., Blasi F.
RT Prep1, a novel functional partner of Pbx proteins
RL EMBO J. 17:1423-1433 (1998).
RN [5]; RE0015495.
RX PUBMED: 9405651.
RA Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P.
RT Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
RL Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997).
RN [6]; RE0015500.
RX PUBMED: 9482740.
RA Berthelsen J., Zappavigna V., Ferretti E., Mavilio F., Blasi F.
RT The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity
RL EMBO J. 17:1434-1445 (1998).
RN [7]; RE0017883.
RX PUBMED: 11972344.
RA Fognani C., Kilstrup-Nielsen C., Berthelsen J., Ferretti E., Zappavigna V., Blasi F.
RT Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors
RL Nucleic Acids Res. 30:2043-2051 (2002).
RN [8]; RE0047951.
RX PUBMED: 15138251.
RA Rave-Harel N., Givens M. L., Nelson S. B., Duong H. A., Coss D., Clark M. E., Hall S. B., Kamps M. P., Mellon P. L.
RT TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1.
RL J. Biol. Chem. 279:30287-30297 (2004).
RN [9]; RE0047970.
RX PUBMED: 11069920.
RA Mikkola I., Bruun J. A., Holm T., Johansen T.
RT Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins.
RL J. Biol. Chem. 276:4109-4118 (2001).
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