AC T09231
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ID T09231
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DT 16.08.2006 (created); din.
DT 11.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Prox-1-xbb1
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SY PROX-1; prox1-xbb1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005717 PROX1; HGNC: PROX1.
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CL C0006; homeo.
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SZ 736 AA; 83.2 kDa (cDNA) (calc.).
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SQ MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQ
SQ HADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTG
SQ SEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSP
SQ SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK
SQ QQLEDMQKQLLHVQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMC
SQ ELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAM
SQ SQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNP
SQ LDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGLVGGHHQPLHQSPLSATTGFTTSTFR
SQ HPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPA
SQ HPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSN
SQ MLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCEL
SQ YRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEV
SQ PEFFKSPNCLQELLHE
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SC translated from EMBL #U44060
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FT 1 734 
PF05044; Homeobox prospero-like protein (PROX1).
FT 2 416 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 583 736 
DNA binding domain (DBD) [4].
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IN T00682 Pax-6; zebra fish, Brachydanio rerio.
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BS R24637.
BS R24642.
BS R24507.
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DR TRANSPATH: MO000085079.
DR EMBL: U44060;
DR UniProtKB: Q92786;
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RN [1]; RE0017255.
RX PUBMED: 8812486.
RA Zinovieva R. D., Duncan M. K., Johnson T. R., Torres R., Polymeropoulos M. H., Tomarev S. I.
RT Structure and chromosomal localization of the human homeobox gene Prox 1
RL Genomics 35:517-522 (1996).
RN [2]; RE0023150.
RX PUBMED: 11139622.
RA Lengler J., Krausz E., Tomarev S., Prescott A., Quinlan R. A., Graw J.
RT Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.
RL Nucleic Acids Res. 29:515-526 (2001).
RN [3]; RE0047970.
RX PUBMED: 11069920.
RA Mikkola I., Bruun J. A., Holm T., Johansen T.
RT Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins.
RL J. Biol. Chem. 276:4109-4118 (2001).
RN [4]; RE0053152.
RX PUBMED: 15205472.
RA Qin J., Gao D. M., Jiang Q. F., Zhou Q., Kong Y. Y., Wang Y., Xie Y. H.
RT Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene.
RL Mol. Endocrinol. 18:2424-2439 (2004).
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