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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T09254 XX ID T09254 XX DT 23.08.2006 (created); jul. DT 21.02.2014 (updated); pos. CO Copyright (C), QIAGEN. XX FA c-Rel XX SY c-Rel; HIVEN86A; Nuclear Factor kappa B c-Rel; p68; p82(hc-rel). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004960 REL; HGNC: REL. XX CL C0020; Rel. XX SZ 619 AA; 68.5 kDa (cDNA) (calc.), 82-85 kDa (SDS) [2] XX SQ MASGAYNPYIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQIMNYYGKGK SQ VRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKEAII SQ TRIKAGINPFNVPEKQLNDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNRA SQ PNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQV SQ AIVFKTPPYCKAITEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDTYGNKAKKQKTTLLF SQ QKLCQDHVETGFRHVDQDGLELLTSGDPPTLASQSAGITVNFPERPRPGLLGSIGEGRYF SQ KKEPNLFSHDAVVREMPTGVSSQAESYYPSPGPISSGLSHHASMAPLPSSSWSSVAHPTP SQ RSGNTNPLSSFSTRTLPSNSQGIPPFLRIPVGNDLNASNACIYNNADDIVGMEASSMPSA SQ DLYGISDPNMLSNCSVNMMTTSSDSMGETDNPRLLSMNLENPSCNSVLDPRDLRQLHQMS SQ SSSMSAGANSNTTVFVSQSDAFEGSDFSCADNSMINESGPSNSTNPNSHGFVQDSQYSGI SQ GSMQNEQLSDSFPYEFFQV XX SC Swiss-Prot#Q04864 XX FT 5 182 PS50254; REL_2. FT 10 178 PF00554; Rel homology domain (RHD). FT 185 280 SM00429; iptmega2. FT 186 280 PF01833; IPT/TIG domain. FT 197 619 PF00478; IMP dehydrogenase / GMP reductase domain. XX IN T09254 c-Rel; human, Homo sapiens. IN T22508 dpf2-isoform1; human, Homo sapiens. XX MX M00053 V$CREL_01. MX M03545 V$CREL_Q6. XX BS R01748. BS R56830. BS R56831. BS R56846. BS R56841. BS R56833. BS R56844. BS R56879. BS R24146. BS R56894. BS R56884. BS R56892. BS R30575. BS R30566. BS R56860. BS R00941. BS R30568. BS R56896. BS R22506. BS R22617. BS R56876. BS R56885. BS R56877. BS R56878. BS R56886. BS R56865. BS R56872. BS R56881. XX DR TRANSPATH: MO000085500. DR EMBL: M11595; HSCRELA. DR EMBL: X75042; DR UniProtKB: Q04864; REL_HUMAN. XX RN [1]; RE0000100. RX PUBMED: 2836068. RA Boehnlein E., Lowenthal J. W., Siekevitz M., Ballard D. W., Franza B. R., Greene W. C. RT The Same Inducible Nuclear Protein Regulates Mitogen Activation of Both the Interleukin-2 Receptor-Alpha Gene and Type 1 HIV RL Cell 53:827-836 (1988). RN [2]; RE0000216. RX PUBMED: 2225078. RA Ballard D. W., Walker W. H., Doerre S., Sista P., Molitor J. A., Dixon E. P., Peffer N. J., Hannink M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [3]; RE0001791. RX PUBMED: 2825023. RA Franza jr B. R., Josephs S. F., Gilman M. Z., Ryan W., Clarkson B. RT Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay RL Nature 330:391-395 (1987). RN [4]; RE0002417. RX PUBMED: 2263603. RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [5]; RE0002922. RX PUBMED: 1406630. RA Kunsch C., Ruben S. M., Rosen C. A. RT Selection of optimal kappaB/Rel DNA-binding motifs: interaction of both subunits of NF-kappaB with DNA is required for transcriptional activation RL Mol. Cell. Biol. 12:4412-4421 (1992). RN [6]; RE0004480. RX PUBMED: 3016517. RA Brownell E., Brien S. J., Nash W. G., Rice N. RT Genetic characterization of human c-rel sequences RL Mol. Cell. Biol. 5:2826-2831 (1985). RN [7]; RE0004507. RX PUBMED: 7925300. RA Naumann M., Scheidereit C. RT Activation of NF-6B in vivo is regulated by multiple phosphorylations RL EMBO J. 13:4597-4607 (1994). RN [8]; RE0004559. RX PUBMED: 1740106. RA Hansen S. K., Nerlov C., Zabel U., Verde P., Johnsen M., Baeuerle P., Blasi F. RT A novel complex between the p65 subunit of NF-kappaB and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene RL EMBO J. 11:205-213 (1992). RN [9]; RE0004565. RX PUBMED: 7935451. RA Sun S.-C., Elwood J., Beraud C., Greene W. C. RT Human T-cell leukemia virus type I Tax activation of NF-kappaB/Rel involves phosphorylation and degradation of IkappaBalpha and RelA (p65)-mediated induction of the c-rel gene RL Mol. Cell. Biol. 14:7377-7384 (1994). RN [10]; RE0004574. RX PUBMED: 1903456. RA Richardson P. M., Gilmore T. D. RT vRel is an inactive member of the Rel family of transcriptional activating proteins RL J. Virol. 65:3122-3130 (1991). RN [11]; RE0004575. RX PUBMED: 1542667. RA Sica A., Tan T.-H., Rice N. R., Kretzschmar M., Ghosh P., Young H. A. RT The c-rel protooncogene product c-Rel but not NF-6B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response gene RL Proc. Natl. Acad. Sci. USA 89:1740-1744 (1992). RN [12]; RE0004576. RX PUBMED: 8455941. RA Crenon I., Beraud C., Simard P., Montagne J., Veschambre P., Jalinot P. RT The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2Ralpha kappaB enhancer include the product of the c-rel proto-oncogene RL Oncogene 8:867-875 (1993). RN [13]; RE0004577. RX PUBMED: 8413585. RA Kerr L. D., Ransone L. J., Wamsley P., Schmitt M. J., Boyer T. G., Zhou Q., Berk A. J., Verma I. M. RT Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappaB RL Nature 365:412-419 (1993). RN [14]; RE0004580. RX PUBMED: 8430069. RA Doerre S., Sista P., Sun S.-C., Ballard D. W., Greene W. C. RT The c-rel protooncogene product represses NF-kappaB p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus RL Proc. Natl. Acad. Sci. USA 90:1023-1027 (1993). RN [15]; RE0004581. RX PUBMED: 8139561. RA Hansen S. K., Baeuerle P. A., Blasi F. RT Purification, reconstitution, and IkappaB association of the c-RelBp65 (RelA) complex, a strong activator of transcription RL Mol. Cell. Biol. 14:2593-2603 (1994). RN [16]; RE0051535. RX PUBMED: 16585559. RA Sanchez-Valdepenas C., Martin A. G., Ramakrishnan P., Wallach D., Fresno M. RT NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity. RL J. Immunol. 176:4666-4674 (2006). RN [17]; RE0054190. RX PUBMED: 12820969. RA Saccani S., Pantano S., Natoli G. RT Modulation of NF-kappaB activity by exchange of dimers. RL Mol. Cell 11:1563-1574 (2003). RN [18]; RE0070954. RX PUBMED: 20460684. RA Tando T., Ishizaka A., Watanabe H., Ito T., Iida S., Haraguchi T., Mizutani T., Izumi T., Isobe T., Akiyama T., Inoue J., Iba H. RT Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. RL J. Biol. Chem. 285:21951-21960 (2010). XX //