AC T09336
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ID T09336
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DT 27.09.2006 (created); sri.
CO Copyright (C), QIAGEN.
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FA NRL-isoform1
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SY AS321; D14S46E; neural retina-specific leucine zipper protein; NRL.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003947 NRL; HGNC: NRL.
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CL C0008; bZIP.
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SZ 237 AA; 25.9 kDa (cDNA) (calc.), 30 kDa (SDS)
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SQ MALPPSPLAMEYVNDFDLMKFEVKREPSEGRPGPPTASLGSTPYSSVPPSPTFSEPGMVG
SQ ATEGTRPGLEELYWLATLQQQLGAGEALGLSPEEAMELLQGQGPVPVDGPHGYYPGSPEE
SQ TGAQHVQLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKR
SQ LQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSSGPGSGDPSHLFL
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SC Swiss-Prot#P54845
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FT 130 224 
PF03131; bZIP Maf transcription factor.
FT 157 221 
SM00338; brlzneu.
FT 159 222 
PS50217; BZIP.
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IN T08520 TBP-isoform1; human, Homo sapiens.
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BS R28009.
BS R28133.
BS R36398.
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DR TRANSPATH: MO000087839.
DR EMBL: M81840;
DR EMBL: M95925;
DR UniProtKB: P54845;
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RN [1]; RE0002541.
RX PUBMED: 1729696.
RA Swaroop A., Xu J., Pawar H., Jackson A., Skolnick C., Agarwal N.
RT A conserved retina-specific gene encodes a basic motif/leucine zipper domain
RL Proc. Natl. Acad. Sci. USA 89:266-270 (1992).
RN [2]; RE0004866.
RX PUBMED: 8108109.
RA Kerppola T. K., Curran T.
RT Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun
RL Oncogene 9:675-684 (1994).
RN [3]; RE0012903.
RX PUBMED: 8552602.
RA Rehemetulla A., Warwar R., Kumar R., Ji X., Zack D. J., Swaroop A.
RT The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression
RL Proc. Natl. Acad. Sci. USA 93:191-195 (1996).
RN [4]; RE0040140.
RX PUBMED: 15001570.
RA Pittler S. J., Zhang Y., Chen S., Mears A. J., Zack D. J., Ren Z., Swain P. K., Yao S., Swaroop A., White J. B.
RT Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity
RL J. Biol. Chem. 279:19800-7 (2004).
RN [5]; RE0048326.
RX PUBMED: 15328344.
RA Friedman J. S., Khanna H., Swain P. K., Denicola R., Cheng H., Mitton K. P., Weber C. H., Hicks D., Swaroop A.
RT The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding protein.
RL J. Biol. Chem. 279:47233-47241 (2004).
RN [6]; RE0067852.
RX PUBMED: 20551322.
RA Roger J. E., Nellissery J., Kim D. S., Swaroop A.
RT Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation.
RL J. Biol. Chem. 285:25637-25644 (2010).
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