AC T09548
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ID T09548
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DT 31.10.2006 (created); smt.
DT 08.10.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA IRF-3
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SY Interferon Regulatory Factor 3; IRF-3; IRF3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002598 IRF3; HGNC: IRF3.
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CL C0022; trp.
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SZ 427 AA; 47.2 kDa (cDNA) (calc.).
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SQ MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA
SQ TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP
SQ DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT
SQ PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG
SQ WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL
SQ PNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTK
SQ RLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMD
SQ FQGPGES
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SC translated from EMBL #Z56281
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FT 1 112 
SM00348; IRF.
FT 7 112 
PF00605; Interferon regulatory factor transcription f.
FT 198 375 
IAD, IRF association domain [2].
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IN T23264 IRF-3a; human, Homo sapiens.
IN T23266 IRF-3c; human, Homo sapiens.
IN T17876 RORgamma; Mammalia.
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MX M01279 V$IRF3_Q3.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R10351.
BS R10352.
BS R10353.
BS R10354.
BS R10355.
BS R10356.
BS R10357.
BS R10358.
BS R10359.
BS R10360.
BS R10361.
BS R10362.
BS R10363.
BS R10364.
BS R10365.
BS R10366.
BS R12440.
BS R14452.
BS R14454.
BS R19557.
BS R19558.
BS R14802.
BS R14440.
BS R34309.
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DR TRANSPATH: MO000089915.
DR EMBL: U86636;
DR EMBL: Z56281;
DR UniProtKB: Q14653;
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RN [1]; RE0016765.
RX PUBMED: 10938111.
RA Lin R., Genin P., Mamane Y., Hiscott J.
RT Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
RL Mol. Cell. Biol. 20:6342-6353 (2000).
RN [2]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [3]; RE0024013.
RX PUBMED: 9660935.
RA Wathelet M. G., Lin C. H., Parekh B. S., Ronco L. V., Howley P. M., Maniatis T.
RT Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
RL Mol. Cell 1:507-518 (1998).
RN [4]; RE0024081.
RX PUBMED: 12473110.
RA Yang H., Lin C. H., Ma G., Orr M., Baffi M. O., Wathelet M. G.
RT Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions.
RL Eur. J. Biochem. 269:6142-6151 (2002).
RN [5]; RE0051557.
RX PUBMED: 15361868.
RA Kawai T., Sato S., Ishii K. J., Coban C., Hemmi H., Yamamoto M., Terai K., Matsuda M., Inoue J., Uematsu S., Takeuchi O., Akira S.
RT Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
RL Nat. Immunol. 5:1061-1068 (2004).
RN [6]; RE0055115.
RX PUBMED: 15661910.
RA Saitoh T., Yamamoto M., Miyagishi M., Taira K., Nakanishi M., Fujita T., Akira S., Yamamoto N., Yamaoka S.
RT A20 is a negative regulator of IFN regulatory factor 3 signaling.
RL J. Immunol. 174:1507-1512 (2005).
RN [7]; RE0068561.
RX PUBMED: 16116171.
RA Yoneyama M., Kikuchi M., Matsumoto K., Imaizumi T., Miyagishi M., Taira K., Foy E., Loo Y. M., Gale M J. r., Akira S., Yonehara S., Kato A., Fujita T.
RT Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
RL J. Immunol. 175:2851-2858 (2005).
RN [8]; RE0070756.
RX PUBMED: 20406818.
RA Nistal-Villan E., Gack M. U., Martinez-Delgado G., Maharaj N. P., Inn K. S., Yang H., Wang R., Aggarwal A. K., Jung J. U., Garcia-Sastre A.
RT Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production.
RL J. Biol. Chem. 285:20252-20261 (2010).
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