AC T09633
XX
ID T09633
XX
DT 08.11.2006 (created); man.
DT 22.11.2007 (updated); ssr.
CO Copyright (C), QIAGEN.
XX
FA FXR
XX
SY BAR; bile acid receptor; farnesoid X activated receptor; HRR-1; HRR1; NR1H4; retinoid X receptor interacting protein 14; RIP-14; RIP14.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002744 Nr1h4.
XX
CL C0002; CC (rec); 2.1.2.7.3.4.
XX
SZ 469 AA; 53.9 kDa (cDNA) (calc.).
XX
SQ MNLIGPSHLQATDEFALSENLFGVLTEHAAGPLGQNLDLESYSPYNNVQFPQVQPQISSS
SQ SYYSNLGFYPQQPEDWYSPGLYELRRMPTESVYQGETEVSEMPVTKKPRMAASSAGRIKG
SQ DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQDCR
SQ LRKCREMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKLCREKT
SQ ELTVDQQTLLDYIMDSYSKQRMPQEITNKILKEEFSAEENFLILTEMATSHVQILVEFTK
SQ RLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPAGHADLLEERIRKSGISDEYIT
SQ PMFSFYKSVGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIYQ
SQ PENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
XX
SC translated from EMBL #U18374
XX
FT 121 192 
SM00399; c4gold.
FT 121 196 
PS51030; NUCLEAR_REC_DBD_2.
FT 122 197 
PF00105; Zinc finger, C4 type (two domains).
FT 124 189 
putative DNA-binding domain [1].
FT 250 469 
putative ligand-binding domain [1].
FT 286 441 
SM00430; holi.
FT 289 465 
PF00104; Ligand-binding domain of nuclear hormon.
XX
IN T08433 RXR-alpha; human, Homo sapiens.
XX
MX M07256 V$FXRRXR_Q5.
MX M01268 V$FXR_Q2.
MX M00631 V$FXR_Q3.
MX M03790 V$FXR_Q5.
MX M03795 V$LXR_Q6.
MX M00964 V$PXR_Q2.
XX
BS R09991.
BS R09990.
BS R09968.
XX
DR TRANSPATH: MO000090868.
DR EMBL: U18374;
DR UniProtKB: Q62735;
XX
RN [1]; RE0016189.
RX PUBMED: 7774010.
RA Forman B. M., Goode E., Chen J., Oro A. E., Bradley D. J., Perlmann T., Noonan D. J., Burka L. T., McMorris T., Lamph W. W., et a. l.
RT Identification of a nuclear receptor that is activated by farnesol metabolites
RL Cell 81:687-693 (1995).
RN [2]; RE0016194.
RX PUBMED: 10334993.
RA Parks D. J., Blanchard S. G., Bledsoe R. K., Chandra G., Consler T. G., Kliewer S. A., Stimmel J. B., Willson T. M., Zavacki A. M., Moore D. D., Lehmann J. M.
RT Bile acids: natural ligands for an orphan nuclear receptor
RL Science 284:1365-1368 (1999).
RN [3]; RE0017935.
RX PUBMED: 11867625.
RA Seo Y. W., Sanyal S., Kim H. J., Won D. H., An J. Y., Amano T., Zavacki A. M., Kwon H. B., Shi Y. B., Kim W. S., Kang H., Moore D. D., Choi H. S.
RT FOR, a novel orphan nuclear receptor related to farnesoid X receptor
RL J. Biol. Chem. 277:17836-17844 (2002).
RN [4]; RE0018127.
RX PUBMED: 10360171.
RA Wang H., Chen J., Hollister K., Sowers L. C., Forman B. M.
RT Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.
RL Mol. Cell 3:543-553 (1999).
RN [5]; RE0023349.
RX PUBMED: 10334992.
RA Makishima M., Okamoto A. Y., Repa J. J., Tu H., Learned R. M., Luk A., Hull M. V., Lustig K. D., Mangelsdorf D. J., Shan B.
RT Identification of a nuclear receptor for bile acids.
RL Science 284:1362-1365 (1999).
RN [6]; RE0051190.
RX PUBMED: 16522742.
RA Honjo Y., Sasaki S., Kobayashi Y., Misawa H., Nakamura H.
RT 1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor.
RL J. Endocrinol. 188:635-643 (2006).
XX
//