AC T09990
XX
ID T09990
XX
DT 06.12.2006 (created); sou.
DT 12.12.2006 (updated); sou.
CO Copyright (C), QIAGEN.
XX
FA CDP-isoform1
XX
SY CCAAT displacement protein; CDP; Clox; cut homeodomain protein; cut-like homeodomain protein; Cux.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004658 CUX1; HGNC: Cux1.
XX
CL C0006; homeo; 3.1.9.2.1.1.
XX
SZ 1505 AA; 164.3 kDa (cDNA) (calc.), 180-200 kDa (SDS)
XX
SQ MLCVRGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF
SQ QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE
SQ TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ
SQ ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN
SQ QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA
SQ QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI
SQ LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES
SQ RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL
SQ NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE
SQ SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT
SQ VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI
SQ RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDEPIRSILQQARREMEAQ
SQ QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN
SQ PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE
SQ AKARETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA
SQ SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG
SQ ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ
SQ QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP
SQ IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT
SQ DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD
SQ MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK
SQ RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD
SQ SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT
SQ PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPTSAPP
SQ PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP
SQ IEWEF
XX
SC Swiss-Prot#P39880-1
XX
FT 251 800 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 542 629 
PF02376; CUT domain.
FT 542 629 
PS51042; CUT.
FT 551 610 
involved in binding to S/MAR-binding factor SATB1 [18].
FT 934 1021 
PF02376; CUT domain.
FT 934 1021 
PS51042; CUT.
FT 943 1007 
involved in binding to S/MAR-binding factor SATB1 [18].
FT 1117 1204 
PF02376; CUT domain.
FT 1117 1204 
PS51042; CUT.
FT 1242 1302 
PS50071; HOMEOBOX_2.
FT 1243 1303 PS50560; CUT_HOMEODOMAIN.
FT 1244 1306 SM00389; HOX_1.
FT 1245 1301 involved in binding to S/MAR-binding factor SATB1 [18].
FT 1245 1301 PF00046; Homeobox domain.
XX
IN T34364 G9A; human, Homo sapiens.
XX
MX M00104 V$CDPCR1_01.
MX M00106 V$CDPCR3HD_01.
MX M00105 V$CDPCR3_01.
MX M00095 V$CDP_01.
MX M00102 V$CDP_02.
MX M01342 V$CDP_03.
MX M01344 V$CDP_04.
MX M04610 V$CDP_Q6_01.
XX
BS R06569.
BS R06570.
BS R06571.
BS R06572.
BS R06573.
BS R06574.
BS R06575.
BS R06576.
BS R06577.
BS R06578.
BS R06579.
BS R06580.
BS R06581.
BS R06582.
BS R06583.
BS R06584.
BS R06585.
BS R06586.
BS R06587.
BS R06588.
BS R06589.
BS R06590.
BS R06591.
BS R06592.
BS R06593.
BS R06594.
BS R06595.
BS R06596.
BS R06597.
BS R06598.
BS R06599.
BS R06600.
BS R06625.
BS R06626.
BS R06627.
BS R06628.
BS R06629.
BS R06630.
BS R06631.
BS R06632.
BS R06633.
BS R06634.
BS R06635.
BS R06636.
BS R06637.
BS R06638.
BS R06639.
BS R06640.
BS R06641.
BS R06642.
BS R06643.
BS R06644.
BS R06645.
BS R06646.
BS R06647.
BS R06648.
BS R06649.
BS R06650.
BS R06651.
BS R06652.
BS R06653.
BS R06654.
BS R06655.
BS R06656.
BS R06657.
BS R06601.
BS R06602.
BS R06603.
BS R06604.
BS R06605.
BS R06606.
BS R06607.
BS R06608.
BS R06609.
BS R06610.
BS R06611.
BS R06612.
BS R06613.
BS R06614.
BS R06615.
BS R06616.
BS R06617.
BS R06618.
BS R06619.
BS R06620.
BS R06621.
BS R06622.
BS R06623.
BS R06624.
BS R06378.
BS R06379.
BS R06380.
BS R06381.
BS R06382.
BS R06383.
BS R06384.
BS R06385.
BS R06386.
BS R06387.
BS R06388.
BS R06389.
BS R06390.
BS R06391.
BS R06392.
BS R06393.
BS R06394.
BS R06395.
BS R03477.
XX
DR TRANSPATH: MO000094267.
DR SMARTDB: SB000139.
DR EMBL: M74099;
DR UniProtKB: P39880-1;
XX
RN [1]; RE0000079.
RX PUBMED: 3607873.
RA Barberis A., Superti-Furga G., Busslinger M.
RT Mutually Exclusive Interaction of the CCAAT-Binding Factor and of a Displacement Protein with Overlapping Sequences of a Histone Gene Promoter
RL Cell 50:347-359 (1987).
RN [2]; RE0000346.
RX PUBMED: 3181130.
RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.
RT The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene
RL EMBO J. 7:3099-3107 (1988).
RN [3]; RE0001031.
RX PUBMED: 1885602.
RA Skalnik D. G., Strauss E. C., Orkin S. H.
RT CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter
RL J. Biol. Chem. 266:16736-16744 (1991).
RN [4]; RE0002047.
RX PUBMED: 2476717.
RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S.
RT The deletion of the distal CCAAT box region of the Agamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein
RL Nucleic Acids Res. 17:6681-6691 (1989).
RN [5]; RE0002967.
RX PUBMED: 7914370.
RA Aufiero B., Neufeld E. J., Orkin S. H.
RT Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/ cut homeodomain protein
RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994).
RN [6]; RE0002972.
RX PUBMED: 7905452.
RA Andres V., Chiara M. D., Mahdavi V.
RT A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins
RL Genes Dev. 8:245-257 (1994).
RN [7]; RE0002973.
RX PUBMED: 7799919.
RA Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A.
RT DNA-binding specificity of the cut repeats from the human cut-like protein
RL Mol. Cell. Biol. 15:129-140 (1995).
RN [8]; RE0003358.
RX PUBMED: 8196661.
RA Dufort D., Nepveu A.
RT The human Cut homeodomain protein represses transcription from the c-myc promoter
RL Mol. Cell. Biol. 14:4251-4257 (1994).
RN [9]; RE0003999.
RX PUBMED: 7759529.
RA Lievens P. M., Donady J. J., Tufarelli C., Neufeld E. J.
RT Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells
RL J. Biol. Chem. 270:12745-12750 (1995).
RN [10]; RE0005002.
RX PUBMED: 1301999.
RA Neufeld E. J., Skalnik D. G., Lievens P. M., Orkin S. H.
RT Human CCAAT dis-placement protein is homologous to the Drosophila homeoprotein, cut
RL Nat. Genet. 1:50-55 (1992).
RN [11]; RE0005004.
RX PUBMED: 7904999.
RA Harada R., Dufort D., Denis-Larose C., Nepveu A.
RT Conserved cut repeats in the human cut homeodomain protein function as DNA binding domains
RL J. Biol. Chem. 269:2062-2067 (1994).
RN [12]; RE0005005.
RX PUBMED: 2784063.
RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.
RT The protein CDP, but not CP1, footprints on the CCAAT region of the g-globin gene in unfractionated B-cell extracts
RL Biochim. Biophys. Acta 1007:237-242 (1989).
RN [13]; RE0017514.
RX PUBMED: 11584018.
RA Santaguida M., Ding Q., Berube G., Truscott M., Whyte P., Nepveu A.
RT Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).
RL J. Biol. Chem. 276:45780-45790 (2001).
RN [14]; RE0017861.
RX PUBMED: 10684263.
RA Stuenkel W., Huang Z., Tan S.-H., O'Connor M. J., Bernard H.-U.
RT Nuclear matrix attachment regions of human papillomavirus type 16 repress or activate the E6 promoter, depending on the physical state of the viral DNA
RL J. Virol. 74:2489-2501 (2000).
RN [15]; RE0042400.
RX PUBMED: 10852958.
RA Li S., Aufiero B., Schiltz R. L., Walsh M. J.
RT Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP
RL Proc. Natl. Acad. Sci. USA 97:7166-71 (2000).
RN [16]; RE0048962.
RX PUBMED: 16574653.
RA Michl P., Knobel B., Downward J.
RT CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility.
RL J. Biol. Chem. 281:15138-15144 (2006).
RN [17]; RE0048983.
RX PUBMED: 15269344.
RA Nishio H., Walsh M. J.
RT CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription.
RL Proc. Natl. Acad. Sci. USA 101:11257-11262 (2004).
RN [18]; RE0015021.
RX PUBMED: 10373541.
RA Liu J., Barnett A., Neufeld E. J., Dudley J. P.
RT Homeoproteins CDP and SATB1interact: potential for tissue-specific regulation
RL Mol. Cell. Biol. 19:4918-4926 (1999).
XX
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