AC T10083
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ID T10083
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DT 05.01.2007 (created); ask.
DT 06.07.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA HNF-3alpha
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SY FOXA1; Hepatocyte Nuclear Factor 3 alpha; HNF-3A; HNF-3alpha; HNF-5; HNF3.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G013745 Foxa1.
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CL C0023; fork head.
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SZ 466 AA; 48.8 kDa (cDNA) (calc.), 50 kDa (SDS)
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SQ MLGTVKMEGHESNDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMT
SQ PASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGAALSPGGMGSMGAQP
SQ AASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLIT
SQ MAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNACFVKVARSPDKPGK
SQ GSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGSGGGGSKGVPENRKDPSGPVNPS
SQ AESPIHRGVHGKASQLEGAPAPGPAASPQTLDHSGATATGGGSELKSPASSSAPPISSGP
SQ GGWICTPLSPTWLAPHESQLHLKGAPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQY
SQ SPYGATLPASLPLGGASVATRSPIEPSALEPAYYQGVYSRPVLNTS
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SC Swiss-Prot#P23512
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FT 168 267 
fork head domain [11].
FT 168 258 
SM00339; forkneu4.
FT 170 264 
PS50039; FORK_HEAD_3.
FT 170 265 
PF00250; Fork head domain.
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IN T08473 AR; mouse, Mus musculus.
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MX M00724 V$HNF3ALPHA_Q6.
MX M01261 V$HNF3A_01.
MX M03827 V$HNF3A_Q6.
MX M00791 V$HNF3_Q6.
MX M01012 V$HNF3_Q6_01.
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BS R08890.
BS R05086.
BS R13062.
BS R13061.
BS R05076.
BS R68653.
BS R01464.
BS R26428.
BS R26429.
BS R26417.
BS R26419.
BS R26420.
BS R26421.
BS R26430.
BS R26431.
BS R04662.
BS R05017.
BS R05019.
BS R05029.
BS R08894.
BS R02895.
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DR TRANSPATH: MO000095670.
DR EMBL: X55955;
DR UniProtKB: P23512;
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RN [1]; RE0000254.
RX PUBMED: 2225060.
RA Weigel D., Jaeckle H.
RT The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?
RL Cell 63:455-456 (1990).
RN [2]; RE0000288.
RX PUBMED: 1638120.
RA Sladek F. M., Darnell J. E.
RT Mechanisms of liver-specific gene expression
RL Curr. Opin. Gen. Dev. 2:256-259 (1992).
RN [3]; RE0000676.
RX PUBMED: 2227418.
RA Lai E., Prezioso V. R., Smith E., Litvin O., Costa R. H., Darnell J. E.
RT HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally
RL Genes Dev. 4:1427-1436 (1990).
RN [4]; RE0000677.
RX PUBMED: 1672118.
RA Lai E., Prezioso V. R., Tao W., Chen W. S., Darnell J. E.
RT Hepatocyte nuclear factor 3alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head
RL Genes Dev. 5:416-427 (1991).
RN [5]; RE0002090.
RX PUBMED: 1672737.
RA Grange T., Roux J., Rigaud G., Pictet R.
RT Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor
RL Nucleic Acids Res. 19:131-139 (1991).
RN [6]; RE0002265.
RX PUBMED: 2922398.
RA Herbst R. S., Friedman N., Darnell J. E., Babiss L. E.
RT Positive and negative regulatory elements in the mouse albumin enhancer
RL Proc. Natl. Acad. Sci. USA 86:1553-1557 (1989).
RN [7]; RE0002542.
RX PUBMED: 1909027.
RA Li C., Lai C., Sigman D. S., Gaynor R. B.
RT Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat
RL Proc. Natl. Acad. Sci. USA 88:7739-7743 (1991).
RN [8]; RE0006510.
RX PUBMED: 8165139.
RA Gregori C., Kahn A., Pichard A. L.
RT Activity of the rat liver-specific aldolase B promoter is restrained by HNF3
RL Nucleic Acids Res. 22:1242-1246 (1994).
RN [9]; RE0006511.
RX PUBMED: 8383844.
RA Gregori C., Kahn A., Pichard A. L.
RT Competition between transcription factors HNF1 nnd HNF3, and alternative cell-specific activation by DBP and C/EBP contribute to the regulation of the liver-specific aldolase B promoter
RL Nucleic Acids Res. 21:897- 903 (1993).
RN [10]; RE0006537.
RX PUBMED: 8029022.
RA Jacob A., Budhiraja S., Qian X., Clevidence D. E., Costa R. H., Reichel R. R.
RT Retinoic acid-mediated activation of HNF-3alpha during EC stem cell differentiation
RL Nucleic Acids Res. 22:2126-2133 (1994).
RN [11]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [12]; RE0014431.
RX PUBMED: 9832435.
RA Dean D. M., Berger R. R., Sanders M. M.
RT A winged-helix family member is involved in a steroid hormone-triggered regulatory circuit
RL Endocrinology 139:4967-4975 (1998).
RN [13]; RE0016757.
RX PUBMED: 8993836.
RA Peterson R. S., Clevidence D. E., Ye H., Costa R. H.
RT Hepatocyte nuclear factor-3 alpha promoter regulation involves recognition by cell-specific factors, thyroid transcription factor-1, and autoactivation.
RL Cell Growth Differ. 8:69-82 (1997).
RN [14]; RE0051642.
RX PUBMED: 18178153.
RA Lee H. J., Hwang M., Chattopadhyay S., Choi H. S., Lee K.
RT Hepatocyte nuclear factor-3 alpha (HNF-3alpha) negatively regulates androgen receptor transactivation in prostate cancer cells.
RL Biochem. Biophys. Res. Commun. 367:481-486 (2008).
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