AC T10282
XX
ID T10282
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DT 01.03.2007 (created); ask.
DT 27.09.2011 (updated); hna.
CO Copyright (C), QIAGEN.
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FA Otx2
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SY orthodenticle related homeobox protein 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004500 Otx2.
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CL C0006; homeo; 3.1.3.17.2.1.
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SZ 289 AA; 31.6 kDa (cDNA) (calc.).
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SQ MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKT
SQ RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKSSPARE
SQ VSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYT
SQ QASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLST
SQ QGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL
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SC Swiss-Prot#P80206
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FT 36 96 
PS50071; HOMEOBOX_2.
FT 38 94 
PS50552; PAX.
FT 38 100 
SM00389; HOX_1.
FT 39 95 
PF00046; Homeobox domain.
FT 153 235 
PF03529; Otx1 transcription factor.
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IN T09219 Grg4; mouse, Mus musculus.
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MX M08892 V$CRX_Q6.
MX M01387 V$OTX2_01.
MX M01719 V$OTX2_Q3.
MX M04623 V$OTX2_Q3_01.
MX M01117 V$OTX_Q1.
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BS R15733.
BS R36675.
BS R36740.
BS R36741.
BS R30060.
BS R15750.
BS R15751.
BS R30158.
BS R30161.
BS R30164.
BS R30167.
BS R30153.
BS R30156.
BS R35869.
BS R16820.
BS R20636.
BS R73346.
BS R15752.
BS R15753.
BS R15754.
BS R15755.
BS R15756.
BS R15759.
BS R16176.
BS R04992.
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DR TRANSPATH: MO000101723.
DR UniProtKB: P80206;
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RN [1]; RE0005031.
RX PUBMED: 1353865.
RA Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Rambaldi M., Boncinelli E.
RT Nested expression domains of four homeobox genes in developing rostral brain
RL Nature 358:687-690 (1992).
RN [2]; RE0005172.
RX PUBMED: 8101484.
RA Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M. R., Nigro V., Boncinelli E.
RT A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
RL EMBO J. 12:2735-2747 (1993).
RN [3]; RE0015734.
RX PUBMED: 9371841.
RA Smidt M. P., van Schaick H. S., Lanctot C., Tremblay J. J., Cox J. J., van der Kleij A. A., Wolterink G., Drouin J., Burbach J. P.
RT A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
RL Proc. Natl. Acad. Sci. USA 94:13305-13310 (1997).
RN [4]; RE0024916.
RX PUBMED: 12055180.
RA Zhang Y., Miki T., Iwanaga T., Koseki Y., Okuno M., Sunaga Y., Ozaki N., Yano H., Koseki H., Seino S.
RT Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family.
RL J. Biol. Chem. 277:28065-28069 (2002).
RN [5]; RE0054218.
RX PUBMED: 17060451.
RA Heimbucher T., Murko C., Bajoghli B., Aghaallaei N., Huber A., Stebegg R., Eberhard D., Fink M., Simeone A., Czerny T.
RT Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.
RL Mol. Cell. Biol. 27:340-351 (2007).
RN [6]; RE0066993.
RX PUBMED: 19843539.
RA Reichman S., Kalathur R. K., Lambard S., Ait-Ali N., Yang Y., Lardenois A., Ripp R., Poch O., Zack D. J., Sahel J. A., Leveillard T.
RT The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.
RL Hum. Mol. Genet. 19:250-261 (2010).
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