AC T09219
XX
ID T09219
XX
DT 14.08.2006 (created); din.
DT 09.09.2008 (updated); jag.
CO Copyright (C), QIAGEN.
XX
FA Grg4
XX
SY 5730411M05Rik; Bce1; ESTM13; ESTM14; Grg4; Groucho-related protein 4; X83333.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G008772 Tle4.
XX
SZ 766 AA; 82.9 kDa (cDNA) (calc.).
XX
SQ MYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY
SQ VMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNA
SQ IIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDE
SQ KKHHDNDHQRDRDSIKSSSVSPSASFRGSEKHRNSTDYSSESKKQKTEEKEIAARYDSDG
SQ EKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASVASSSSTPSSKS
SQ KELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVP
SQ CPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPH
SQ HHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHG
SQ EVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRT
SQ LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH
SQ NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLG
SQ YCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNA
SQ WRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
XX
SC translated from EMBL #AF229633
XX
FT 1 134 
PF03920; Groucho/TLE N-terminal Q-rich domain.
FT 35 693 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 470 507 
SM00320; WD40_4.
FT 472 507 
PF00400; WD40.
FT 476 649 
PS50294; WD_REPEATS_REGION.
FT 513 554 
SM00320; WD40_4.
FT 517 554 
PF00400; WD40.
FT 559 598 
SM00320; WD40_4.
FT 561 598 
PF00400; WD40.
FT 566 607 
PS50082; WD_REPEATS_2.
FT 601 640 SM00320; WD40_4.
FT 603 640 PF00400; WD40.
FT 608 649 PS50082; WD_REPEATS_2.
FT 643 681 SM00320; WD40_4.
FT 683 722 SM00320; WD40_4.
FT 685 722 PF00400; WD40.
FT 690 721 PS50082; WD_REPEATS_2.
FT 690 766 PS50294; WD_REPEATS_REGION.
FT 723 763 SM00320; WD40_4.
FT 727 763 PF00400; WD40.
XX
IN T10281 Gbx2; mouse, Mus musculus.
IN T09218 Msx-1; mouse, Mus musculus.
IN T10282 Otx2; mouse, Mus musculus.
IN T00545 POU2F1; human, Homo sapiens.
XX
DR TRANSPATH: MO000085022.
DR EMBL: AF229633;
DR UniProtKB: Q62441;
XX
RN [1]; RE0047958.
RX PUBMED: 16002402.
RA Rave-Harel N., Miller N. L., Givens M. L., Mellon P. L.
RT The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.
RL J. Biol. Chem. 280:30975-30983 (2005).
RN [2]; RE0054218.
RX PUBMED: 17060451.
RA Heimbucher T., Murko C., Bajoghli B., Aghaallaei N., Huber A., Stebegg R., Eberhard D., Fink M., Simeone A., Czerny T.
RT Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.
RL Mol. Cell. Biol. 27:340-351 (2007).
XX
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