AC T10289
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ID T10289
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DT 05.03.2007 (created); sri.
DT 07.03.2007 (updated); sri.
CO Copyright (C), QIAGEN.
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FA MITF-M1
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SY Mi; Microphthalmia; microphthalmia-associated transcription factor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002681 MITF; HGNC: MITF.
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CL C0012; bHLH-ZIP; 1.2.6.1.4.9.
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SZ 419 AA; 46.9 kDa (cDNA) (calc.).
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SQ MLEMLEYNHYQVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDH
SQ VMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVI
SQ DDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPN
SQ IKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMR
SQ WNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLI
SQ PSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEA
SQ NQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC
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SC translated from EMBL #Z29678
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FT 3 295 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 202 258 
PS50888; HLH.
FT 205 258 
PF00010; Helix-loop-helix DNA-binding domain.
FT 210 263 
SM00353; finulus.
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IN T10291 TFEA-isoform1; human, Homo sapiens.
IN T10290 tfeb; human, Homo sapiens.
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MX M01034 V$EBOX_Q6_01.
MX M07050 V$MITF_Q4.
MX M02099 V$MITF_Q6.
MX M01029 V$TFE_Q6.
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BS R15441.
BS R15430.
BS R15438.
BS R15440.
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DR TRANSPATH: MO000101985.
DR EMBL: Z29678;
DR UniProtKB: O75030-9;
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RN [1]; RE0003425.
RX PUBMED: 8069297.
RA Tachibana M., Perez-Jurado L. A., Nakayama A., Hodgkinson C. A., Li X., Schneider M., Miki T., Fex J., Francke U., Arnheiter H.
RT Cloning of MITF, the human homolog of the mouse microphthalmia gene, and assignment to human chromosome 3, region p14.1-p12.3
RL Hum. Mol. Genet. 3:553-557 (1994).
RN [2]; RE0024401.
RX PUBMED: 8995290.
RA Yasumoto K., Yokoyama K., Takahashi K., Tomita Y., Shibahara S.
RT Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes.
RL J. Biol. Chem. 272:503-509 (1997).
RN [3]; RE0024474.
RX PUBMED: 12048204.
RA Saito H., Yasumoto K., Takeda K., Takahashi K., Fukuzaki A., Orikasa S., Shibahara S.
RT Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1.
RL J. Biol. Chem. 277:28787-28794 (2002).
RN [4]; RE0024619.
RX PUBMED: 10747853.
RA Takeda K., Yasumoto K., Takada R., Takada S., Watanabe K., Udono T., Saito H., Takahashi K., Shibahara S.
RT Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a.
RL J. Biol. Chem. 275:14013-14016 (2000).
RN [5]; RE0049462.
RX PUBMED: 15507434.
RA Miller A. J., Levy C., Davis I. J., Razin E., Fisher D. E.
RT Sumoylation of MITF and its related family members TFE3 and TFEB.
RL J. Biol. Chem. 280:146-155 (2005).
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