AC T10645
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ID T10645
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DT 22.11.2000 (created); mkl.
DT 06.07.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA STAT5
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SY signal transducer and activator of transcription 5.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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IN T32110 SIRT1; mouse, Mus musculus.
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BS R14236.
BS R35038.
BS R26378.
BS R21645.
BS R72841.
BS R72842.
BS R66602.
BS R72834.
BS R72836.
BS R36435.
BS R30634.
BS R68659.
BS R60663.
BS R60666.
BS R60668.
BS R60670.
BS R60673.
BS R60674.
BS R60676.
BS R60678.
BS R60684.
BS R60687.
BS R60690.
BS R60692.
BS R60695.
BS R60696.
BS R60698.
BS R25764.
BS R66607.
BS R22520.
BS R19616.
BS R60506.
BS R33084.
BS R56952.
BS R56955.
BS R72827.
BS R72833.
BS R13351.
BS R22351.
BS R60224.
BS R73423.
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DR TRANSPATH: MO000019530.
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RN [1]; RE0010751.
RX PUBMED: 7538664.
RA Ruff-Jamison S., Chen K., Cohen S.
RT Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver
RL Proc. Natl. Acad. Sci. USA 92:4215-4218 (1995).
RN [2]; RE0022765.
RX PUBMED: 9162019.
RA Yu C. L., Burakoff S. J.
RT Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation.
RL J. Biol. Chem. 272:14017-14020 (1997).
RN [3]; RE0028899.
RX PUBMED: 11731619.
RA Horsch K., Schaller M. D., Hynes N. E.
RT The protein tyrosine phosphatase-PEST is implicated in the negative regulation of epidermal growth factor on PRL signaling in mammary epithelial cells.
RL Mol. Endocrinol. 15:2182-96 (2001).
RN [4]; RE0029945.
RX PUBMED: 12435740.
RA Kovanen P. E., Rosenwald A., Fu J., Hurt E. M., Lam L. T., Giltnane J. M., Wright G., Staudt L. M., Leonard W. J.
RT Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling.
RL J. Biol. Chem. 278:5205-13 (2003).
RN [5]; RE0031906.
RX PUBMED: 15012602.
RA Auernhammer C. J., Dorn F., Vlotides G., Hengge S., Kopp F. B., Spoettl G., Cengic N., Engelhardt D., Weber M. M.
RT The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells.
RL J. Endocrinol. 180:479-86 (2004).
RN [6]; RE0032050.
RX PUBMED: 14764533.
RA Peltola K. J., Paukku K., Aho T. L., Ruuska M., Silvennoinen O., Koskinen P. J.
RT Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.
RL Blood 103:3744-50 (2004).
RN [7]; RE0038473.
RX PUBMED: 11418668.
RA Reche P. A., Soumelis V., Gorman D. M., Clifford T., Liu Mr, Travis M., Zurawski S. M., Johnston J., Liu Y. J., Spits H., de Waal Malefyt R., Kastelein R. A., Bazan J. F.
RT Human thymic stromal lymphopoietin preferentially stimulates myeloid cells
RL J. Immunol. 167:336-43 (2001).
RN [8]; RE0046465.
RX PUBMED: 12975368.
RA Wang M., Liu Y. E., Goldberg I. D., Shi Y. E.
RT Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG
RL J. Biol. Chem. 278:47319-25 (2003).
RN [9]; RE0051886.
RX PUBMED: 17070988.
RA Motta M., Accornero P., Taulli R., Bernabei P., Desrivieres S., Baratta M.
RT Leptin enhances STAT-3 phosphorylation in HC11 cell line: effect on cell differentiation and cell viability.
RL Mol. Cell. Endocrinol. 263:149-155 (2007).
RN [10]; RE0052559.
RX PUBMED: 18024957.
RA Cocolakis E., Dai M., Drevet L., Ho J., Haines E., Ali S., Lebrun J. J.
RT Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation.
RL J. Biol. Chem. 283:1293-1307 (2008).
RN [11]; RE0053932.
RX PUBMED: 14698140.
RA Iwamoto T., Senga T., Adachi K., Hamaguchi M.
RT Stat3-dependent induction of interleukin-3 receptor expression in leukemia inhibitory factor-stimulated M1 mouse leukemia cells.
RL Cytokine 25:136-139 (2004).
RN [12]; RE0053982.
RX PUBMED: 18430728.
RA Hintzen C., Evers C., Lippok B. E., Volkmer R., Heinrich P. C., Radtke S., Hermanns H. M.
RT Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.
RL J. Biol. Chem. 283:19465-19477 (2008).
RN [13]; RE0054552.
RX PUBMED: 17716968.
RA Nagy T., Wei H., Shen T. L., Peng X., Liang C. C., Gan B., Guan J. L.
RT Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland.
RL J. Biol. Chem. 282:31766-31776 (2007).
RN [14]; RE0064453.
RX PUBMED: 10949031.
RA Guthridge M. A., Stomski F. C., Barry E. F., Winnall W., Woodcock J. M., McClure B. J., Dottore M., Berndt M. C., Lopez A. F.
RT Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.
RL Mol. Cell 6:99-108 (2000).
RN [15]; RE0064492.
RX PUBMED: 12920017.
RA Guthridge M. A., Barry E. F., Felquer F. A., McClure B. J., Stomski F. C., Ramshaw H., Lopez A. F.
RT The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappaB and induction of bcl-2.
RL Blood 103:820-827 (2004).
RN [16]; RE0064691.
RX PUBMED: 15833084.
RA Nyga R., Pecquet C., Harir N., Gu H., Dhennin-Duthille I., Regnier A., Gouilleux-Gruart V., Lassoued K., Gouilleux F.
RT Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.
RL Biochem. J. 390:359-366 (2005).
RN [17]; RE0065045.
RX PUBMED: 9558373.
RA Callus B. A., Mathey-Prevot B.
RT Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors.
RL Blood 91:3182-3192 (1998).
RN [18]; RE0065425.
RX PUBMED: 19632985.
RA Dumoutier L., de Meester C., Tavernier J., Renauld J. C.
RT New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain.
RL J. Biol. Chem. 284:26377-26384 (2009).
RN [19]; RE0065994.
RX PUBMED: 15166220.
RA Dumoutier L., Tounsi A., Michiels T., Sommereyns C., Kotenko S. V., Renauld J. C.
RT Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.
RL J. Biol. Chem. 279:32269-32274 (2004).
RN [20]; RE0066281.
RX PUBMED: 9447970.
RA Itoh T., Liu R., Yokota T., Arai K. I., Watanabe S.
RT Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor.
RL Mol. Cell. Biol. 18:742-752 (1998).
RN [21]; RE0066419.
RX PUBMED: 11070174.
RA Shimoda K., Kato K., Aoki K., Matsuda T., Miyamoto A., Shibamori M., Yamashita M., Numata A., Takase K., Kobayashi S., Shibata S., Asano Y., Gondo H., Sekiguchi K., Nakayama K., Nakayama T., Okamura T., Okamura S., Niho Y., Nakayama K.
RT Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.
RL Immunity 13:561-571 (2000).
RN [22]; RE0067088.
RX PUBMED: 18430737.
RA Kovanen P. E., Bernard J., Al-Shami A., Liu C., Bollenbacher-Reilley J., Young L., Pise-Masison C., Spolski R., Leonard W. J.
RT T-cell development and function are modulated by dual specificity phosphatase DUSP5.
RL J. Biol. Chem. 283:17362-17369 (2008).
RN [23]; RE0067449.
RX PUBMED: 16096272.
RA Zvonic S., Baugh JE J. r., Arbour-Reily P., Mynatt R. L., Stephens J. M.
RT Cross-talk among gp130 cytokines in adipocytes.
RL J. Biol. Chem. 280:33856-33863 (2005).
RN [24]; RE0067485.
RX PUBMED: 15465815.
RA Nonami A., Kato R., Taniguchi K., Yoshiga D., Taketomi T., Fukuyama S., Harada M., Sasaki A., Yoshimura A.
RT Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.
RL J. Biol. Chem. 279:52543-52551 (2004).
RN [25]; RE0067697.
RX PUBMED: 11445538.
RA Lindeman G. J., Wittlin S., Lada H., Naylor M. J., Santamaria M., Zhang J. G., Starr R., Hilton D. J., Alexander W. S., Ormandy C. J., Visvader J.
RT SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
RL Genes Dev. 15:1631-1636 (2001).
RN [26]; RE0067754.
RX PUBMED: 20051625.
RA Walker E. C., McGregor N. E., Poulton I. J., Solano M., Pompolo S., Fernandes T. J., Constable M. J., Nicholson G. C., Zhang J. G., Nicola N. A., Gillespie M. T., Martin T. J., Sims N. A.
RT Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice.
RL J. Clin. Invest. 120:582-592 (2010).
RN [27]; RE0067764.
RX PUBMED: 16547273.
RA Fritz D. K., Kerr C., Tong L., Smyth D., Richards C. D.
RT Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6.
RL J. Immunol. 176:4352-4360 (2006).
RN [28]; RE0068170.
RX PUBMED: 17609432.
RA Brender C., Tannahill G. M., Jenkins B. J., Fletcher J., Columbus R., Saris C. J., Ernst M., Nicola N. A., Hilton D. J., Alexander W. S., Starr R.
RT Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
RL Blood 110:2528-2536 (2007).
RN [29]; RE0068797.
RX PUBMED: 16616006.
RA He F., Stephens J. M.
RT Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes.
RL Biochem. Biophys. Res. Commun. 344:95-98 (2006).
RN [30]; RE0069067.
RX PUBMED: 15630138.
RA Inoue H., Kato R., Fukuyama S., Nonami A., Taniguchi K., Matsumoto K., Nakano T., Tsuda M., Matsumura M., Kubo M., Ishikawa F., Moon B. G., Takatsu K., Nakanishi Y., Yoshimura A.
RT Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.
RL J. Exp. Med. 201:73-82 (2005).
RN [31]; RE0069089.
RX PUBMED: 15607729.
RA Scheller J., Schuster B., Holscher C., Yoshimoto T., Rose-John S.
RT No inhibition of IL-27 signaling by soluble gp130.
RL Biochem. Biophys. Res. Commun. 326:724-728 (2005).
RN [32]; RE0070066.
RX PUBMED: 20696842.
RA Martin P., Gomez M., Lamana A., Cruz-Adalia A., Ramirez-Huesca M., Ursa M. A., Yanez-Mo M., Sanchez-Madrid F.
RT CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation.
RL Mol. Cell. Biol. 30:4877-4889 (2010).
RN [33]; RE0070213.
RX PUBMED: 21148801.
RA Grenningloh R., Tai T. S., Frahm N., Hongo T. C., Chicoine A. T., Brander C., Kaufmann D. E., Ho I. C.
RT Ets-1 maintains IL-7 receptor expression in peripheral T cells.
RL J. Immunol. 186:969-976 (2011).
RN [34]; RE0070321.
RX PUBMED: 21343299.
RA Wu H., Suzuki T., Carey B., Trapnell B. C., McCormack F. X.
RT Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages.
RL J. Biol. Chem. 286:14932-14940 (2011).
RN [35]; RE0070958.
RX PUBMED: 21829342.
RA Beyer T., Busse M., Hristov K., Gurbiel S., Smida M., Haus U. U., Ballerstein K., Pfeuffer F., Weismantel R., Schraven B., Lindquist J. A.
RT Integrating signals from the T-cell receptor and the interleukin-2 receptor.
RL PLoS Comput. Biol. 7:e1002121 (2011).
RN [36]; RE0023424.
RX PUBMED: 8943308.
RA Sawyer S. T., Penta K.
RT Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction.
RL J. Biol. Chem. 271:32430-32437 (1996).
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