AC T14840
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ID T14840
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DT 10.03.2005 (created); nvo.
DT 20.06.2016 (updated); vis.
CO Copyright (C), QIAGEN.
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FA IRF-8
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SY Interferon Cis-Sequence Binding Protein; interferon consensus sequence binding protein; IRF-8.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T15118 CBP; Mammalia.
IN T09319 IRF-1; mouse, Mus musculus.
IN T17701 Miz-1; Mammalia.
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MX M00699 V$ICSBP_Q6.
MX M01665 V$IRF8_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R73681.
BS R40207.
BS R59964.
BS R38773.
BS R71473.
BS R71476.
BS R67581.
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DR TRANSPATH: MO000047006.
DR TRANSCOMPEL: C00478.
DR TRANSCOMPEL: C00483.
DR TRANSCOMPEL: C00599.
DR TRANSCOMPEL: C00601.
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RN [1]; RE0017733.
RX PUBMED: 9742224.
RA Schaper F., Kirchhoff S., Posern G., Koster M., Oumard A., Sharf R., Levi B. Z., Hauser H.
RT Functional domains of interferon regulatory factor I (IRF-1)
RL Biochem. J. 335:147-157 (1998).
RN [2]; RE0023151.
RX PUBMED: 12055236.
RA Meraro D., Gleit-Kielmanowicz M., Hauser H., Levi B. Z.
RT IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding protein, and IFN regulatory factor-4: characterization of a new subtype of IFN-stimulated response element.
RL J. Immunol. 168:6224-6231 (2002).
RN [3]; RE0030790.
RX PUBMED: 12904288.
RA Alter-Koltunoff M., Ehrlich S., Dror N., Azriel A., Eilers M., Hauser H., Bowen H., Barton C. H., Tamura T., Ozato K., Levi B. Z.
RT Nramp1-mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1, and Miz-1.
RL J. Biol. Chem. 278:44025-32 (2003).
RN [4]; RE0032755.
RX PUBMED: 12417340.
RA Masumi A., Tamaoki S., Wang I. M., Ozato K., Komuro K.
RT IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 promoter activity in macrophages.
RL FEBS Lett. 531:348-53 (2002).
RN [5]; RE0054797.
RX PUBMED: 16484229.
RA Zhao J., Kong H. J., Li H., Huang B., Yang M., Zhu C., Bogunovic M., Zheng F., Mayer L., Ozato K., Unkeless J., Xiong H.
RT IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways.
RL J. Biol. Chem. 281:10073-10080 (2006).
RN [6]; RE0055125.
RX PUBMED: 17579016.
RA Kong H. J., Anderson D. E., Lee C. H., Jang M. K., Tamura T., Tailor P., Cho H. K., Cheong J., Xiong H., Morse HC 3. r. d., Ozato K.
RT Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages.
RL J. Immunol. 179:26-30 (2007).
RN [7]; RE0062943.
RX PUBMED: 19201866.
RA Kim J. Y., Ozato K.
RT The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.
RL J. Immunol. 182:2131-2140 (2009).
RN [8]; RE0064770.
RX PUBMED: 18802049.
RA Vila-del Sol V., Punzon C., Fresno M.
RT IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages.
RL J. Immunol. 181:4461-4470 (2008).
RN [9]; RE0066125.
RX PUBMED: 17785777.
RA Osterlund P. I., Pietila T. E., Veckman V., Kotenko S. V., Julkunen I.
RT IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes.
RL J. Immunol. 179:3434-3442 (2007).
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