AC T09319
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ID T09319
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DT 18.09.2006 (created); man.
DT 13.02.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA IRF-1
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SY IRF1; Interferon regulatory factor 1; IRF-1; IRF1; ISGF2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001058 Irf1.
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CL C0022; trp.
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SZ 329 AA; 37.3 kDa (cDNA) (calc.).
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SQ MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAI
SQ HTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTRNQR
SQ KERKSKSSRDTKSKTKRKLCGDVSPDTFSDGLSSSTLPDDHSSYTTQGYLGQDLDMERDI
SQ TPALSPCVVSSSLSEWHMQMDIIPDSTTDLYNLQVSPMPSTSEAATDEDEEGKIAEDLMK
SQ LFEQSEWQPTHIDGKGYLLNEPGTQLSSVYGDFSCKEEPEIDSPRGDIGIGIQHVFTEMK
SQ NMDSIMWMDSLLGNSVRLPPSIQAIPCAP
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SC Swiss-Prot#P15314
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FT 1 125 
DNA-binding domain [12].
FT 1 114 
SM00348; IRF.
FT 5 114 
PF00605; Interferon regulatory factor transcription f.
FT 12 21 
alpha-helix 1 [17].
FT 26 29 
beta-strand 1 [17].
FT 33 37 
beta-strand 2 [17].
FT 48 61 
alpha-helix 2 [17].
FT 74 87 
alpha-helix 3 [17].
FT 91 94 
beta-strand 3 [17].
FT 104 109 
beta-strand 4 [17].
FT 115 139 nuclear translocation, contains NLS [12].
FT 164 219 heterodimerization domain [12].
FT 185 256 transactivation domain [12].
FT 201 263 IAD2, IRF association domain 2 [13].
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IN T14840 IRF-8; Mammalia.
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MX M00062 V$IRF1_01.
MX M07045 V$IRF1_Q5.
MX M00747 V$IRF1_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
XX
BS R22210.
BS R00950.
BS R00915.
BS R00917.
BS R00919.
BS R12726.
BS R29808.
BS R25792.
BS R13576.
BS R01051.
BS R14488.
BS R03126.
BS R33049.
BS R33052.
BS R27162.
BS R27163.
BS R27166.
XX
DR TRANSPATH: MO000087377.
DR EMBL: M21065;
DR UniProtKB: P15314;
DR PDB: 1IF1.
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RN [1]; RE0000099.
RX PUBMED: 3409321.
RA Miyamoto M., Fujita T., Kimura Y., Maruyama M., Harada H., Sudo Y., Miyata T., Taniguchi T.
RT Regulated Expression of a Gene Encoding a Nuclear Factor, IRF-1, That Specifically Binds to IFN-beta Gene Regulatory Elements
RL Cell 54:903-913 (1988).
RN [2]; RE0000171.
RX PUBMED: 2208287.
RA Harada H., Willison K., Sakakibara J., Miyamoto M., Fujita T., Taniguchi T.
RT Absence of the type I IFN system in EC cells: transcriptional activator (ITF-1) and repressor (IRF-2) genes are developmentally regulated
RL Cell 63:303-312 (1990).
RN [3]; RE0000373.
RX PUBMED: 2850164.
RA Fujita T., Sakakibara J., Sudo Y., Miyamoto M., Kimura Y., Taniguchi T.
RT Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements
RL EMBO J. 11:3397-3405 (1988).
RN [4]; RE0001630.
RX PUBMED: 2038316.
RA Pleiman C. M., Gimpel S. D., Park L. S., Harada H., Taniguchi T., Ziegler S. F.
RT Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter
RL Mol. Cell. Biol. 11:3052-3059 (1991).
RN [5]; RE0002174.
RX PUBMED: 1886766.
RA Watanabe N., Sakakibara J., Hovanessian A. G., Taniguchi T., Fujita T.
RT Activation of IFN-beta element by IRF-1 requires a post-translational event in addition to IRF-1 synthesis
RL Nucleic Acids Res. 19:4421-4428 (1991).
RN [6]; RE0002927.
RX PUBMED: 8168491.
RA Harroch S., Revel M., Chebath J.
RT Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA
RL EMBO J. 13:1942-1949 (1994).
RN [7]; RE0002930.
RX PUBMED: 7687740.
RA Tanaka N., Kawakami T., Taniguchi T.
RT Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system
RL Mol. Cell. Biol. 13:4531-4538 (1993).
RN [8]; RE0003461.
RX PUBMED: 8402903.
RA Matsuyama T., Kimura T., Kitagawa M., Pfeffer K., Kawakami T., Watanabe N., Kuendig T. M., Amakawa R., Kishihara K., Wakeham A., Potter J., Furlonger C. L., Narendran A., Suzuki H., Ohashi P. S., Paige C. J., Taniguchi T., Mak T. W.
RT Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte developement
RL Cell 75:83-97 (1993).
RN [9]; RE0003462.
RX PUBMED: 2911367.
RA Fujita T., Kimura Y., Miyamoto M., Barsoumian E. L., Taniguchi T.
RT Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1
RL Nature 337:270-272 (1989).
RN [10]; RE0003463.
RX PUBMED: 8265581.
RA Ruffner H., Reis L. F. L., Naef D., Weissmann C.
RT Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1
RL Proc. Natl. Acad. Sci. USA 90:11503-11507 (1993).
RN [11]; RE0003464.
RX PUBMED: 7510419.
RA Kamijo R., Harada H., Matsuyama T., Bosland M., Gerecitano J., Shapiro D., Le J., Koh S. I., Kimura T., Green S. J., Mak T. W., Taniguchi T., Vilcek J.
RT Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
RL Science 263:1612-1615 (1994).
RN [12]; RE0017733.
RX PUBMED: 9742224.
RA Schaper F., Kirchhoff S., Posern G., Koster M., Oumard A., Sharf R., Levi B. Z., Hauser H.
RT Functional domains of interferon regulatory factor I (IRF-1)
RL Biochem. J. 335:147-157 (1998).
RN [13]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [14]; RE0017930.
RX PUBMED: 10415056.
RA Salkowski C. A., Kopydlowski K., Blanco J., Cody M. J., McNally R., Vogel S. N.
RT IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice.
RL J. Immunol. 163:1529-1536 (1999).
RN [15]; RE0019562.
RX PUBMED: 9422515.
RA ESCALANTE C.R., YIE J., THANOS D., AGGARWAL A.K.
RT Structure of IRF-1 with bound DNA reveals determinants of interferon regulation.
RL Nature 391:103-106 (1998).
RN [16]; RE0048273.
RX PUBMED: 12387893.
RA Nakagawa K., Yokosawa H.
RT PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1.
RL FEBS Lett. 530:204-208 (2002).
RN [17]; RE0050674.
RX PUBMED: 10487755.
RA Fujii Y., Shimizu T., Kusumoto M., Kyogoku Y., Taniguchi T., Hakoshima T.
RT Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.
RL EMBO J. 18:5028-5041 (1999).
RN [18]; RE0053348.
RX PUBMED: 17018642.
RA Negishi H., Fujita Y., Yanai H., Sakaguchi S., Ouyang X., Shinohara M., Takayanagi H., Ohba Y., Taniguchi T., Honda K.
RT Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.
RL Proc. Natl. Acad. Sci. USA 103:15136-15141 (2006).
RN [19]; RE0068392.
RX PUBMED: 20308629.
RA Stirnweiss A., Ksienzyk A., Klages K., Rand U., Grashoff M., Hauser H., Kroger A.
RT IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
RL J. Immunol. 184:5179-5185 (2010).
RN [20]; RE0068850.
RX PUBMED: 20200270.
RA Hoshino K., Sasaki I., Sugiyama T., Yano T., Yamazaki C., Yasui T., Kikutani H., Kaisho T.
RT Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.
RL J. Immunol. 184:3341-3345 (2010).
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