AC T18218
XX
ID T18218
XX
DT 23.10.2002 (created); spi.
DT 18.03.2016 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA STAT3{pY705}
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
IN T15045 nanog; human, Homo sapiens.
XX
BS R63809.
BS R63036.
BS R41250.
BS R66751.
BS R66753.
BS R66082.
BS R66085.
BS R63268.
BS R63269.
BS R32362.
BS R32365.
BS R65036.
XX
DR TRANSPATH: MO000033357.
XX
RN [1]; RE0018082.
RX PUBMED: 8626374.
RA Kaptein A., Paillard V., Saunders M.
RT Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction.
RL J. Biol. Chem. 271:5961-5964 (1996).
RN [2]; RE0023678.
RX PUBMED: 11016927.
RA Hermanns H. M., Radtke S., Schaper F., Heinrich P. C., Behrmann I.
RT Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor.
RL J. Biol. Chem. 275:40742-40748 (2000).
RN [3]; RE0029151.
RX PUBMED: 11773079.
RA Giraud S., Bienvenu F., Avril S., Gascan H., Heery D. M., Coqueret O.
RT Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
RL J. Biol. Chem. 277:8004-11 (2002).
RN [4]; RE0041933.
RX PUBMED: 11163768.
RA Gao B., Shen X., Kunos G., Meng Q., Goldberg I. D., Rosen E. M., Fan S.
RT Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells
RL FEBS Lett. 488:179-184 (2001).
RN [5]; RE0047403.
RX PUBMED: 15659653.
RA Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C. P., Jing N., Cao X.
RT The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.
RL Mol. Biol. Cell 16:1569-1583 (2005).
RN [6]; RE0047521.
RX PUBMED: 16007195.
RA Niwa Y., Kanda H., Shikauchi Y., Saiura A., Matsubara K., Kitagawa T., Yamamoto J., Kubo T., Yoshikawa H.
RT Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma.
RL Oncogene 24:6406-6417 (2005).
RN [7]; RE0047988.
RX PUBMED: 15385932.
RA Cho-Vega J. H., Rassidakis G. Z., Amin H. M., Tsioli P., Spurgers K., Remache Y. K., Vega F., Goy A. H., Gilles F., Medeiros L. J.
RT Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma.
RL Leukemia 18:1872-1878 (2004).
RN [8]; RE0050457.
RX PUBMED: 16636048.
RA Darnowski J. W., Goulette F. A., Guan Y. J., Chatterjee D., Yang Z. F., Cousens L. P., Chin Y. E.
RT Stat3 cleavage by caspases: impact on full-length Stat3 expression, fragment formation, and transcriptional activity.
RL J. Biol. Chem. 281:17707-17717 (2006).
RN [9]; RE0053305.
RX PUBMED: 17909010.
RA Lo H. W., Hsu S. C., Xia W., Cao X., Shih J. Y., Wei Y., Abbruzzese J. L., Hortobagyi G. N., Hung M. C.
RT Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
RL Cancer Res. 67:9066-9076 (2007).
RN [10]; RE0053327.
RX PUBMED: 15923602.
RA Proietti C., Salatino M., Rosemblit C., Carnevale R., Pecci A., Kornblihtt A. R., Molinolo A. A., Frahm I., Charreau E. H., Schillaci R., Elizalde P. V.
RT Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.
RL Mol. Cell. Biol. 25:4826-4840 (2005).
RN [11]; RE0053982.
RX PUBMED: 18430728.
RA Hintzen C., Evers C., Lippok B. E., Volkmer R., Heinrich P. C., Radtke S., Hermanns H. M.
RT Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.
RL J. Biol. Chem. 283:19465-19477 (2008).
RN [12]; RE0054958.
RX PUBMED: 10922477.
RA Terstegen L., Maassen B. G., Radtke S., Behrmann I., Schaper F., Heinrich P. C., Graeve L., Gatsios P.
RT Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA.
RL FEBS Lett. 478:100-104 (2000).
RN [13]; RE0055138.
RX PUBMED: 18611949.
RA Ray S., Lee C., Hou T., Boldogh I., Brasier A. R.
RT Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution.
RL Nucleic Acids Res. 36:4510-4520 (2008).
RN [14]; RE0055295.
RX PUBMED: 17344214.
RA Saxena N. K., Vertino P. M., Anania F. A., Sharma D.
RT Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
RL J. Biol. Chem. 282:13316-13325 (2007).
RN [15]; RE0055651.
RX PUBMED: 17575145.
RA Yamasaki F., Johansen M. J., Zhang D., Krishnamurthy S., Felix E., Bartholomeusz C., Aguilar R. J., Kurisu K., Mills G. B., Hortobagyi G. N., Ueno N. T.
RT Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
RL Cancer Res. 67:5779-5788 (2007).
RN [16]; RE0055719.
RX PUBMED: 15528381.
RA Stout B. A., Bates M. E., Liu L. Y., Farrington N. N., Bertics P. J.
RT IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils.
RL J. Immunol. 173:6409-6417 (2004).
RN [17]; RE0059949.
RX PUBMED: 15665043.
RA Faffe D. S., Flynt L., Mellema M., Whitehead T. R., Bourgeois K., Panettieri RA J. r., Silverman E. S., Shore S. A.
RT Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta.
RL Am. J. Physiol. Lung Cell. Mol. Physiol. 288:L1040-8 (2005).
RN [18]; RE0062651.
RX PUBMED: 17823122.
RA Jiang X., Borgesi R. A., McKnight N. C., Kaur R., Carpenter C. L., Balk S. P.
RT Activation of nonreceptor tyrosine kinase Bmx/Etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and ErbB3 in prostate cancer cells.
RL J. Biol. Chem. 282:32689-32698 (2007).
RN [19]; RE0063497.
RX PUBMED: 18192275.
RA Bai Y., Ahmad U., Wang Y., Li J. H., Choy J. C., Kim R. W., Kirkiles-Smith N., Maher S. E., Karras J. G., Bennett C. F., Bothwell A. L., Pober J. S., Tellides G.
RT Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.
RL J. Biol. Chem. 283:6832-6842 (2008).
RN [20]; RE0063927.
RX PUBMED: 12832423.
RA Matthews V., Schuster B., Schutze S., Bussmeyer I., Ludwig A., Hundhausen C., Sadowski T., Saftig P., Hartmann D., Kallen K. J., Rose-John S.
RT Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
RL J. Biol. Chem. 278:38829-38839 (2003).
RN [21]; RE0064701.
RX PUBMED: 15277698.
RA Humphrey R. K., Beattie G. M., Lopez A. D., Bucay N., King C. C., Firpo M. T., Rose-John S., Hayek A.
RT Maintenance of pluripotency in human embryonic stem cells is STAT3 independent.
RL Stem Cells 22:522-530 (2004).
RN [22]; RE0064946.
RX PUBMED: 18955562.
RA Pecaric-Petkovic T., Didichenko S. A., Kaempfer S., Spiegl N., Dahinden C. A.
RT Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.
RL Blood 113:1526-1534 (2009).
RN [23]; RE0065001.
RX PUBMED: 19265112.
RA Saleh A., Shan L., Halayko A. J., Kung S., Gounni A. S.
RT Critical role for STAT3 in IL-17A-mediated CCL11 expression in human airway smooth muscle cells.
RL J. Immunol. 182:3357-3365 (2009).
RN [24]; RE0065065.
RX PUBMED: 15604419.
RA Huang A., Zhang Y. Y., Chen K., Hatakeyama K., Keaney JF J. r.
RT Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.
RL Circ. Res. 96:164-171 (2005).
RN [25]; RE0065249.
RX PUBMED: 16951370.
RA Rahman M. S., Yamasaki A., Yang J., Shan L., Halayko A. J., Gounni A. S.
RT IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways.
RL J. Immunol. 177:4064-4071 (2006).
RN [26]; RE0065419.
RX PUBMED: 17204547.
RA Brand S., Dambacher J., Beigel F., Zitzmann K., Heeg M. H., Weiss T. S., Prufer T., Olszak T., Steib C. J., Storr M., Goke B., Diepolder H., Bilzer M., Thasler W. E., Auernhammer C. J.
RT IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.
RL Am. J. Physiol. Gastrointest. Liver Physiol. 292:G1019-28 (2007).
RN [27]; RE0065525.
RX PUBMED: 17438334.
RA Ziesche E., Bachmann M., Kleinert H., Pfeilschifter J., Muhl H.
RT The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells.
RL J. Biol. Chem. 282:16006-16015 (2007).
RN [28]; RE0065735.
RX PUBMED: 15883164.
RA Yang C. H., Murti A., Valentine W. J., Du Z., Pfeffer L. M.
RT Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway.
RL J. Biol. Chem. 280:25849-25853 (2005).
RN [29]; RE0065752.
RX PUBMED: 15459016.
RA Crowder C., Dahle O., Davis R. E., Gabrielsen O. S., Rudikoff S.
RT PML mediates IFN-alpha-induced apoptosis in myeloma by regulating TRAIL induction.
RL Blood 105:1280-1287 (2005).
RN [30]; RE0066370.
RX PUBMED: 18801736.
RA Kalie E., Jaitin D. A., Podoplelova Y., Piehler J., Schreiber G.
RT The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.
RL J. Biol. Chem. 283:32925-32936 (2008).
RN [31]; RE0066578.
RX PUBMED: 12105218.
RA Velichko S., Wagner T. C., Turkson J., Jove R., Croze E.
RT STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.
RL J. Biol. Chem. 277:35635-35641 (2002).
RN [32]; RE0066623.
RX PUBMED: 18456658.
RA Gakovic M., Ragimbeau J., Francois V., Constantinescu S. N., Pellegrini S.
RT The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor.
RL J. Biol. Chem. 283:18522-18529 (2008).
RN [33]; RE0067007.
RX PUBMED: 19372587.
RA Hawthorne V. S., Huang W. C., Neal C. L., Tseng L. M., Hung M. C., Yu D.
RT ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.
RL Mol. Cancer Res. 7:592-600 (2009).
RN [34]; RE0067067.
RX PUBMED: 20388118.
RA Stevens C. N., Simeone A. M., John S., Ahmed Z., Lucherini O. M., Baldari C. T., Ladbury J. E.
RT T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation.
RL Biochem. J. 428:429-437 (2010).
RN [35]; RE0067414.
RX PUBMED: 20526368.
RA Oberbach A., Schlichting N., Bluher M., Kovacs P., Till H., Stolzenburg J. U., Neuhaus J.
RT Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections.
RL PLoS ONE 5:e10882 (2010).
RN [36]; RE0067677.
RX PUBMED: 17881458.
RA Pollack V., Sarkozi R., Banki Z., Feifel E., Wehn S., Gstraunthaler G., Stoiber H., Mayer G., Montesano R., Strutz F., Schramek H.
RT Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signaling.
RL Am. J. Physiol. Renal Physiol. 293:F1714-26 (2007).
RN [37]; RE0067713.
RX PUBMED: 20088942.
RA Rychli K., Kaun C., Hohensinner P. J., Rega G., Pfaffenberger S., Vyskocil E., Breuss J. M., Furnkranz A., Uhrin P., Zaujec J., Niessner A., Maurer G., Huber K., Wojta J.
RT The inflammatory mediator oncostatin M induces angiopoietin 2 expression in endothelial cells in vitro and in vivo.
RL J. Thromb. Haemost. 8:596-604 (2010).
RN [38]; RE0067727.
RX PUBMED: 19565514.
RA Hintzen C., Quaiser S., Pap T., Heinrich P. C., Hermanns H. M.
RT Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis.
RL Arthritis Rheum. 60:1932-1943 (2009).
RN [39]; RE0067792.
RX PUBMED: 16459330.
RA Stross C., Radtke S., Clahsen T., Gerlach C., Volkmer-Engert R., Schaper F., Heinrich P. C., Hermanns H. M.
RT Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.
RL J. Biol. Chem. 281:8458-8468 (2006).
RN [40]; RE0067841.
RX PUBMED: 18524891.
RA de la Iglesia N., Konopka G., Lim K. L., Nutt C. L., Bromberg J. F., Frank D. A., Mischel P. S., Louis D. N., Bonni A.
RT Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.
RL J. Neurosci. 28:5870-5878 (2008).
RN [41]; RE0067844.
RX PUBMED: 17028186.
RA Diveu C., Venereau E., Froger J., Ravon E., Grimaud L., Rousseau F., Chevalier S., Gascan H.
RT Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor.
RL J. Biol. Chem. 281:36673-36682 (2006).
RN [42]; RE0068014.
RX PUBMED: 18179886.
RA Arita K., South A. P., Hans-Filho G., Sakuma T. H., Lai-Cheong J., Clements S., Odashiro M., Odashiro D. N., Hans-Neto G., Hans N. R., Holder M. V., Bhogal B. S., Hartshorne S. T., Akiyama M., Shimizu H., McGrath J. A.
RT Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis.
RL Am. J. Hum. Genet. 82:73-80 (2008).
RN [43]; RE0068111.
RX PUBMED: 15194700.
RA Dreuw A., Radtke S., Pflanz S., Lippok B. E., Heinrich P. C., Hermanns H. M.
RT Characterization of the signaling capacities of the novel gp130-like cytokine receptor.
RL J. Biol. Chem. 279:36112-36120 (2004).
RN [44]; RE0068128.
RX PUBMED: 20507639.
RA Cheng H. L., Su S. J., Huang L. W., Hsieh B. S., Hu Y. C., Hung T. C., Chang K. L.
RT Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation.
RL Mol. Cancer 9:126 (2010).
RN [45]; RE0068135.
RX PUBMED: 19050043.
RA Eulenfeld R., Schaper F.
RT A new mechanism for the regulation of Gab1 recruitment to the plasma membrane.
RL J. Cell Sci. 122:55-64 (2009).
RN [46]; RE0068228.
RX PUBMED: 15944400.
RA Shushakova N., Tkachuk N., Dangers M., Tkachuk S., Park J. K., Hashimoto K., Haller H., Dumler I.
RT Urokinase-induced activation of the gp130/Tyk2/Stat3 pathway mediates a pro-inflammatory effect in human mesangial cells via expression of the anaphylatoxin C5a receptor.
RL J. Cell Sci. 118:2743-2753 (2005).
RN [47]; RE0068254.
RX PUBMED: 14611646.
RA Fischer P., Lehmann U., Sobota R. M., Schmitz J., Niemand C., Linnemann S., Haan S., Behrmann I., Yoshimura A., Johnston J. A., Muller-Newen G., Heinrich P. C., Schaper F.
RT The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
RL Biochem. J. 378:449-460 (2004).
RN [48]; RE0068341.
RX PUBMED: 20584990.
RA Larsen J. V., Hansen M., Moller B., Madsen P., Scheller J., Nielsen M., Petersen C. M.
RT Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.
RL Mol. Cell. Biol. 30:4175-4187 (2010).
RN [49]; RE0068571.
RX PUBMED: 12565872.
RA He B., You L., Uematsu K., Matsangou M., Xu Z., He M., McCormick F., Jablons D. M.
RT Cloning and characterization of a functional promoter of the human SOCS-3 gene.
RL Biochem. Biophys. Res. Commun. 301:386-391 (2003).
RN [50]; RE0068650.
RX PUBMED: 16887796.
RA Saura M., Zaragoza C., Bao C., Herranz B., Rodriguez-Puyol M., Lowenstein C. J.
RT Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression.
RL J. Biol. Chem. 281:30057-30062 (2006).
RN [51]; RE0068820.
RX PUBMED: 17085445.
RA Metz S., Wiesinger M., Vogt M., Lauks H., Schmalzing G., Heinrich P. C., Mueller-Newen G.
RT Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins.
RL J. Biol. Chem. 282:1238-1248 (2007).
RN [52]; RE0069025.
RX PUBMED: 19254694.
RA Muromoto R., Taira N., Ikeda O., Shiga K., Kamitani S., Togi S., Kawakami S., Sekine Y., Nanbo A., Oritani K., Matsuda T.
RT The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.
RL Biochem. Biophys. Res. Commun. 382:63-68 (2009).
RN [53]; RE0069102.
RX PUBMED: 18503751.
RA Ohbayashi N., Taira N., Kawakami S., Togi S., Sato N., Ikeda O., Kamitani S., Muromoto R., Sekine Y., Matsuda T.
RT An RNA biding protein, Y14 interacts with and modulates STAT3 activation.
RL Biochem. Biophys. Res. Commun. 372:475-479 (2008).
RN [54]; RE0069145.
RX PUBMED: 16636663.
RA Sekine Y., Tsuji S., Ikeda O., Sato N., Aoki N., Aoyama K., Sugiyama K., Matsuda T.
RT Regulation of STAT3-mediated signaling by LMW-DSP2.
RL Oncogene 25:5801-5806 (2006).
RN [55]; RE0069162.
RX PUBMED: 15143062.
RA Yeh M., Gharavi N. M., Choi J., Hsieh X., Reed E., Mouillesseaux K. P., Cole A. L., Reddy S. T., Berliner J. A.
RT Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway.
RL J. Biol. Chem. 279:30175-30181 (2004).
RN [56]; RE0069167.
RX PUBMED: 16331268.
RA Muromoto R., Nakao K., Watanabe T., Sato N., Sekine Y., Sugiyama K., Oritani K., Shimoda K., Matsuda T.
RT Physical and functional interactions between Daxx and STAT3.
RL Oncogene 25:2131-2136 (2006).
RN [57]; RE0069557.
RX PUBMED: 11593385.
RA Wei L. H., Kuo M. L., Chen C. A., Chou C. H., Cheng W. F., Chang M. C., Su J. L., Hsieh C. Y.
RT The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway.
RL Oncogene 20:5799-5809 (2001).
RN [58]; RE0070421.
RX PUBMED: 21135123.
RA Sarkar S., Han J., Sinsimer K. S., Liao B., Foster R. L., Brewer G., Pestka S.
RT RNA-binding protein AUF1 regulates lipopolysaccharide-induced IL10 expression by activating IkappaB kinase complex in monocytes.
RL Mol. Cell. Biol. 31:602-615 (2011).
RN [59]; RE0070563.
RX PUBMED: 21689417.
RA Shackleford T. J., Zhang Q., Tian L., Vu T. T., Korapati A. L., Baumgartner A., Le X. F., Liao W. S., Claret F. X.
RT Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.
RL Breast Cancer Res. 13:R65 (2011).
RN [60]; RE0070958.
RX PUBMED: 21829342.
RA Beyer T., Busse M., Hristov K., Gurbiel S., Smida M., Haus U. U., Ballerstein K., Pfeuffer F., Weismantel R., Schraven B., Lindquist J. A.
RT Integrating signals from the T-cell receptor and the interleukin-2 receptor.
RL PLoS Comput. Biol. 7:e1002121 (2011).
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