AC T25057
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ID T25057
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DT 21.10.2004 (created); cch.
DT 08.05.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA alpha-synuclein
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SY NACP; non A-beta component of AD amyloid; non-A4 component of amyloid precursor; PARK1; PD1; SNCA; synuclein, alpha (non A4 component of amyloid precursor).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G010154 SNCA; HGNC: SNCA.
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EX brain,,,adult; detectable; immunoprecipitation; protein; [15] [16].
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IN T04997 p53; rat, Rattus norvegicus.
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BS R39749.
BS R39750.
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DR TRANSPATH: MO000044264.
DR EMBL: D31839;
DR UniProtKB: P37840;
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RN [1]; RE0025014.
RX PUBMED: 11431533.
RA Shimura H., Schlossmacher M. G., Hattori N., Frosch M. P., Trockenbacher A., Schneider R., Mizuno Y., Kosik K. S., Selkoe D. J.
RT Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
RL Science 293:263-269 (2001).
RN [2]; RE0025090.
RX PUBMED: 12859888.
RA Giasson B. I., Lee V. M.
RT Are ubiquitination pathways central to Parkinson's disease?
RL Cell 114:1-8 (2003).
RN [3]; RE0025094.
RX PUBMED: 15364911.
RA Hodara R., Norris E. H., Giasson B. I., Mishizen-Eberz A. J., Lynch D. R., Lee V. M., Ischiropoulos H.
RT Functional Consequences of {alpha}-Synuclein Tyrosine Nitration.
RL J. Biol. Chem. 279:47746-47753 (2004).
RN [4]; RE0035826.
RX PUBMED: 15207266.
RA Dalfo E., Barrachina M., Rosa J. L., Ambrosio S., Ferrer I.
RT Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.
RL Neurobiol. Dis. 16:92-97 (2004).
RN [5]; RE0035864.
RX PUBMED: 12121974.
RA Pan Z. Z., Bruening W., Giasson B. I., Lee V. M., Godwin A. K.
RT Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways.
RL J. Biol. Chem. 277:35050-35060 (2002).
RN [6]; RE0045855.
RX PUBMED: 12928483.
RA Iwata A., Maruyama M., Akagi T., Hashikawa T., Kanazawa I., Tsuji S., Nukina N.
RT Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies
RL Hum. Mol. Genet. 12:2625-35 (2003).
RN [7]; RE0049443.
RX PUBMED: 16096643.
RA Sato S., Chiba T., Sakata E., Kato K., Mizuno Y., Hattori N., Tanaka K.
RT 14-3-3eta is a novel regulator of parkin ubiquitin ligase.
RL EMBO J. 25:211-221 (2006).
RN [8]; RE0049642.
RX PUBMED: 12672538.
RA Wersinger C., Sidhu A.
RT Attenuation of dopamine transporter activity by alpha-synuclein.
RL Neurosci. Lett. 340:189-192 (2003).
RN [9]; RE0052187.
RX PUBMED: 17039976.
RA Paciello O., Wojcik S., Engel W. K., McFerrin J., Askanas V.
RT Parkin and its association with alpha-synuclein and AbetaPP in inclusion-body myositis and AbetaPP-overexpressing cultured human muscle fibers.
RL Acta Myol. 25:13-22 (2006).
RN [10]; RE0052960.
RX PUBMED: 18329380.
RA Tashiro M., Kojima M., Kihara H., Kasai K., Kamiyoshihara T., Ueda K., Shimotakahara S.
RT Characterization of fibrillation process of alpha-synuclein at the initial stage.
RL Biochem. Biophys. Res. Commun. 369:910-914 (2008).
RN [11]; RE0054411.
RX PUBMED: 11438481.
RA Sharma N., Hewett J., Ozelius L. J., Ramesh V., McLean P. J., Breakefield X. O., Hyman B. T.
RT A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study.
RL Am. J. Pathol. 159:339-344 (2001).
RN [12]; RE0055969.
RX PUBMED: 11687285.
RA Payton J. E., Perrin R. J., Clayton D. F., George J. M.
RT Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells.
RL Mol. Brain Res. 95:138-145 (2001).
RN [13]; RE0063103.
RX PUBMED: 18975920.
RA Luk K. C., Mills I. P., Trojanowski J. Q., Lee V. M.
RT Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
RL Biochemistry 47:12614-12625 (2008).
RN [14]; RE0069968.
RX PUBMED: 11447312.
RA Kuusisto E., Salminen A., Alafuzoff I.
RT Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies.
RL Neuroreport 12:2085-2090 (2001).
RN [15]; RE0025046.
RX PUBMED: 12695511.
RA Ihara M., Tomimoto H., Kitayama H., Morioka Y., Akiguchi I., Shibasaki H., Noda M., Kinoshita M.
RT Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies.
RL J. Biol. Chem. 278:24095-24102 (2003).
RN [16]; RE0025092.
RX PUBMED: 12551928.
RA Snyder H., Mensah K., Theisler C., Lee J., Matouschek A., Wolozin B.
RT Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function.
RL J. Biol. Chem. 278:11753-11759 (2003).
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