TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T27800 XX ID T27800 XX DT 10.03.2005 (created); nvo. DT 31.05.2013 (updated); vad. CO Copyright (C), QIAGEN. XX FA securin XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T32445 Ku70; Mammalia. IN T32444 Ku80; Mammalia. XX BS R16689. XX DR TRANSPATH: MO000047453. XX RN [1]; RE0024669. RX PUBMED: 11598127. RA Bembenek J., Yu H. RT Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a. RL J. Biol. Chem. 276:48237-48242 (2001). RN [2]; RE0026631. RX PUBMED: 10922056. RA Gmachl M., Gieffers C., Podtelejnikov A. V., Mann M., Peters J. M. RT The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. RL Proc. Natl. Acad. Sci. USA 97:8973-8 (2000). RN [3]; RE0035155. RX PUBMED: 10906323. RA Pei L. RT Activation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function. RL J. Biol. Chem. 275:31191-31198 (2000). RN [4]; RE0038099. RX PUBMED: 12194817. RA Waizenegger I., Gimenez-Abian J., Wernic D., Peters J. RT Regulation of human separase by securin binding and autocleavage RL Curr. Biol. 12:1368 (2002). RN [5]; RE0039211. RX PUBMED: 12456649. RA Habu T., Kim S. H., Weinstein J., Matsumoto T. RT Identification of a MAD2-binding protein, CMT2, and its role in mitosis RL EMBO J. 21:6419-28 (2002). RN [6]; RE0039224. RX PUBMED: 14744753. RA Dai W., Wang Q., Liu T., Swamy M., Fang Y., Xie S., Mahmood R., Yang Y. M., Xu M., Rao C. V. RT Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency RL Cancer Res. 64:440-5 (2004). RN [7]; RE0039229. RX PUBMED: 10781616. RA Chien W., Pei L. RT A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product RL J. Biol. Chem. 275:19422-7 (2000). RN [8]; RE0039239. RX PUBMED: 9892021. RA Zhang X., Horwitz G. A., Prezant T. R., Valentini A., Nakashima M., Bronstein M. D., Melmed S. RT Structure, expression, and function of human pituitary tumor- transforming gene (PTTG) RL Mol. Endocrinol. 13:156-66 (1999). RN [9]; RE0044137. RX PUBMED: 15178645. RA Tfelt-Hansen J., Yano S., Bandyopadhyay S., Carroll R., Brown E. M., Chattopadhyay N. RT Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells RL Endocrinology 145:4222-31 (2004). RN [10]; RE0049718. RX PUBMED: 15558010. RA Rape M., Kirschner M. W. RT Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. RL Nature 432:588-595 (2004). RN [11]; RE0049883. RX PUBMED: 16921029. RA Miller J. J., Summers M. K., Hansen D. V., Nachury M. V., Lehman N. L., Loktev A., Jackson P. K. RT Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. RL Genes Dev. 20:2410-2420 (2006). RN [12]; RE0050022. RX PUBMED: 17376772. RA Seki A., Fang G. RT CKAP2 Is a Spindle-associated Protein Degraded by APC/C-Cdh1 during Mitotic Exit. RL J. Biol. Chem. 282:15103-15113 (2007). RN [13]; RE0050032. RX PUBMED: 17443186. RA Reddy S. K., Rape M., Margansky W. A., Kirschner M. W. RT Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. RL Nature 446:921-925 (2007). RN [14]; RE0050268. RX PUBMED: 16413484. RA Rape M., Reddy S. K., Kirschner M. W. RT The processivity of multiubiquitination by the APC determines the order of substrate degradation. RL Cell 124:89-103 (2006). RN [15]; RE0050447. RX PUBMED: 15989971. RA Gorr I. H., Boos D., Stemmann O. RT Mutual inhibition of separase and Cdk1 by two-step complex formation. RL Mol. Cell 19:135-141 (2005). RN [16]; RE0050997. RX PUBMED: 17604273. RA Holland A. J., Bottger F., Stemmann O., Taylor S. S. RT Protein phosphatase 2A and separase form a complex regulated by separase autocleavage. RL J. Biol. Chem. 282:24623-24632 (2007). RN [17]; RE0069413. RX PUBMED: 18997788. RA Nilsson J., Yekezare M., Minshull J., Pines J. RT The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. RL Nat. Cell Biol. 10:1411-1420 (2008). XX //