AC T34079
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ID T34079
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DT 26.10.2001 (created); mkl.
DT 10.07.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Jak2
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SY Jak-2; janus kinase 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006328 Jak2.
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CP C4HD [17].
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IN T30560 ErbB4; mouse, Mus musculus.
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DR TRANSPATH: MO000022052.
DR UniProtKB: Q62120;
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RN [1]; RE0021232.
RX PUBMED: 10228162.
RA Takaoka A., Tanaka N., Mitani Y., Miyazaki T., Fujii H., Sato M., Kovarik P., Decker T., Schlessinger J., Taniguchi T.
RT Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling
RL EMBO J. 18:2480-2488 (1999).
RN [2]; RE0023366.
RX PUBMED: 10779328.
RA Saharinen P., Takaluoma K., Silvennoinen O.
RT Regulation of the Jak2 tyrosine kinase by its pseudokinase domain.
RL Mol. Cell. Biol. 20:3387-3395 (2000).
RN [3]; RE0025716.
RX PUBMED: 8943354.
RA Jiao H., Berrada K., Yang W., Tabrizi M., Platanias L. C., Yi T.
RT Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1.
RL Mol. Cell. Biol. 16:6985-92 (1996).
RN [4]; RE0028588.
RX PUBMED: 7499280.
RA Wang X. Y., Fuhrer D. K., Marshall M. S., Yang Y. C.
RT Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.
RL J. Biol. Chem. 270:27999-8002 (1995).
RN [5]; RE0028899.
RX PUBMED: 11731619.
RA Horsch K., Schaller M. D., Hynes N. E.
RT The protein tyrosine phosphatase-PEST is implicated in the negative regulation of epidermal growth factor on PRL signaling in mammary epithelial cells.
RL Mol. Endocrinol. 15:2182-96 (2001).
RN [6]; RE0036013.
RX PUBMED: 15044591.
RA Huang Y., Kim S. O., Yang N., Jiang J., Frank S. J.
RT Physical and functional interaction of growth hormone and insulin-like growth factor-I signaling elements.
RL Mol. Endocrinol. 18:1471-1485 (2004).
RN [7]; RE0038539.
RX PUBMED: 10975815.
RA Delgado M., Ganea D.
RT Inhibition of IFN-gamma-induced janus kinase-1-STAT1 activation in macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide
RL J. Immunol. 165:3051-7 (2000).
RN [8]; RE0043205.
RX PUBMED: 9092791.
RA Ghilardi N., Skoda R. C.
RT The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
RL Mol. Endocrinol. 11:393-9 (1997).
RN [9]; RE0048541.
RX PUBMED: 10551884.
RA Sayeski P. P., Ali M. S., Safavi A., Lyles M., Kim S. O., Frank S. J., Bernstein K. E.
RT A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn.
RL J. Biol. Chem. 274:33131-33142 (1999).
RN [10]; RE0051792.
RX PUBMED: 17519353.
RA Sakamoto K., Creamer B. A., Triplett A. A., Wagner K. U.
RT The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
RL Mol. Endocrinol. 21:1877-1892 (2007).
RN [11]; RE0051833.
RX PUBMED: 11821424.
RA Xie J., LeBaron M. J., Nevalainen M. T., Rui H.
RT Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells.
RL J. Biol. Chem. 277:14020-14030 (2002).
RN [12]; RE0051853.
RX PUBMED: 16847321.
RA Nilsson J., Bjursell G., Kannius-Janson M.
RT Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells.
RL Mol. Cell. Biol. 26:5663-5674 (2006).
RN [13]; RE0051874.
RX PUBMED: 11971965.
RA Ungureanu D., Saharinen P., Junttila I., Hilton D. J., Silvennoinen O.
RT Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.
RL Mol. Cell. Biol. 22:3316-3326 (2002).
RN [14]; RE0052183.
RX PUBMED: 8013458.
RA Dusanter-Fourt I., Muller O., Ziemiecki A., Mayeux P., Drucker B., Djiane J., Wilks A., Harpur A. G., Fischer S., Gisselbrecht S.
RT Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells.
RL EMBO J. 13:2583-2591 (1994).
RN [15]; RE0052366.
RX PUBMED: 16754961.
RA Akhtar N., Streuli C. H.
RT Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia.
RL J. Cell Biol. 173:781-793 (2006).
RN [16]; RE0052859.
RX PUBMED: 17027227.
RA Godeny M. D., Sayyah J., VonDerLinden D., Johns M., Ostrov D. A., Caldwell-Busby J., Sayeski P. P.
RT The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.
RL Cell. Signal. 19:600-609 (2007).
RN [17]; RE0053327.
RX PUBMED: 15923602.
RA Proietti C., Salatino M., Rosemblit C., Carnevale R., Pecci A., Kornblihtt A. R., Molinolo A. A., Frahm I., Charreau E. H., Schillaci R., Elizalde P. V.
RT Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.
RL Mol. Cell. Biol. 25:4826-4840 (2005).
RN [18]; RE0053468.
RX PUBMED: 15619518.
RA Bhardwaj N., Rosas L. E., Lafuse W. P., Satoskar A. R.
RT Leishmania inhibits STAT1-mediated IFN-gamma signaling in macrophages: increased tyrosine phosphorylation of dominant negative STAT1beta by Leishmania mexicana.
RL Int. J. Parasitol. 35:75-82 (2005).
RN [19]; RE0053578.
RX PUBMED: 10556830.
RA Blanchette J., Racette N., Faure R., Siminovitch K. A., Olivier M.
RT Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation.
RL Eur. J. Immunol. 29:3737-3744 (1999).
RN [20]; RE0053787.
RX PUBMED: 10421843.
RA Sasaki A., Yasukawa H., Suzuki A., Kamizono S., Syoda T., Kinjyo I., Sasaki M., Johnston J. A., Yoshimura A.
RT Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.
RL Genes Cells 4:339-351 (1999).
RN [21]; RE0053982.
RX PUBMED: 18430728.
RA Hintzen C., Evers C., Lippok B. E., Volkmer R., Heinrich P. C., Radtke S., Hermanns H. M.
RT Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.
RL J. Biol. Chem. 283:19465-19477 (2008).
RN [22]; RE0054009.
RX PUBMED: 11457894.
RA Ernst M., Inglese M., Waring P., Campbell I. K., Bao S., Clay F. J., Alexander W. S., Wicks I. P., Tarlinton D. M., Novak U., Heath J. K., Dunn A. R.
RT Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.
RL J. Exp. Med. 194:189-203 (2001).
RN [23]; RE0064019.
RX PUBMED: 19231233.
RA Seo J. Y., Kim D. Y., Lee Y. S., Ro J. Y.
RT Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma.
RL Cytokine 46:51-60 (2009).
RN [24]; RE0064202.
RX PUBMED: 19197936.
RA Kar S., Ukil A., Das P. K.
RT Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kappaB and JAK/STAT pathways.
RL Eur. J. Immunol. 39:741-751 (2009).
RN [25]; RE0064453.
RX PUBMED: 10949031.
RA Guthridge M. A., Stomski F. C., Barry E. F., Winnall W., Woodcock J. M., McClure B. J., Dottore M., Berndt M. C., Lopez A. F.
RT Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.
RL Mol. Cell 6:99-108 (2000).
RN [26]; RE0064492.
RX PUBMED: 12920017.
RA Guthridge M. A., Barry E. F., Felquer F. A., McClure B. J., Stomski F. C., Ramshaw H., Lopez A. F.
RT The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappaB and induction of bcl-2.
RL Blood 103:820-827 (2004).
RN [27]; RE0064691.
RX PUBMED: 15833084.
RA Nyga R., Pecquet C., Harir N., Gu H., Dhennin-Duthille I., Regnier A., Gouilleux-Gruart V., Lassoued K., Gouilleux F.
RT Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.
RL Biochem. J. 390:359-366 (2005).
RN [28]; RE0064740.
RX PUBMED: 17638849.
RA Ramshaw H. S., Guthridge M. A., Stomski F. C., Barry E. F., Ooms L., Mitchell C. A., Begley C. G., Lopez A. F.
RT The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
RL Blood 110:3582-3590 (2007).
RN [29]; RE0064848.
RX PUBMED: 18071309.
RA Tao W. J., Lin H., Sun T., Samanta A. K., Arlinghaus R.
RT BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor.
RL Oncogene 27:3194-3200 (2008).
RN [30]; RE0064920.
RX PUBMED: 19109256.
RA Chen J., Olsen J., Ford S., Mirza S., Walker A., Murphy J. M., Young I. G.
RT A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode.
RL J. Biol. Chem. 284:5763-5773 (2009).
RN [31]; RE0064924.
RX PUBMED: 16343349.
RA Ehrhart J., Obregon D., Mori T., Hou H., Sun N., Bai Y., Klein T., Fernandez F., Tan J., Shytle R. D.
RT Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
RL J. Neuroinflammation 2:29 (2005).
RN [32]; RE0065045.
RX PUBMED: 9558373.
RA Callus B. A., Mathey-Prevot B.
RT Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors.
RL Blood 91:3182-3192 (1998).
RN [33]; RE0065217.
RX PUBMED: 19508864.
RA Cho H. J., Jin S. M., Son S. M., Kim Y. W., Hwang J. Y., Hong H. S., Mook-Jung I.
RT Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons.
RL Biochem. Biophys. Res. Commun. 386:175-180 (2009).
RN [34]; RE0065331.
RX PUBMED: 19542364.
RA Tsai C. C., Kai J. I., Huang W. C., Wang C. Y., Wang Y., Chen C. L., Fang Y. T., Lin Y. S., Anderson R., Chen S. H., Tsao C. W., Lin C. F.
RT Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2.
RL J. Immunol. 183:856-864 (2009).
RN [35]; RE0065367.
RX PUBMED: 15284232.
RA Qing Y., Stark G. R.
RT Alternative activation of STAT1 and STAT3 in response to interferon-gamma.
RL J. Biol. Chem. 279:41679-41685 (2004).
RN [36]; RE0065382.
RX PUBMED: 15522878.
RA Qing Y., Costa-Pereira A. P., Watling D., Stark G. R.
RT Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation.
RL J. Biol. Chem. 280:1849-1853 (2005).
RN [37]; RE0066235.
RX PUBMED: 7567993.
RA Inhorn R. C., Carlesso N., Durstin M., Frank D. A., Griffin J. D.
RT Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750.
RL Proc. Natl. Acad. Sci. USA 92:8665-8669 (1995).
RN [38]; RE0066281.
RX PUBMED: 9447970.
RA Itoh T., Liu R., Yokota T., Arai K. I., Watanabe S.
RT Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor.
RL Mol. Cell. Biol. 18:742-752 (1998).
RN [39]; RE0066419.
RX PUBMED: 11070174.
RA Shimoda K., Kato K., Aoki K., Matsuda T., Miyamoto A., Shibamori M., Yamashita M., Numata A., Takase K., Kobayashi S., Shibata S., Asano Y., Gondo H., Sekiguchi K., Nakayama K., Nakayama T., Okamura T., Okamura S., Niho Y., Nakayama K.
RT Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.
RL Immunity 13:561-571 (2000).
RN [40]; RE0067485.
RX PUBMED: 15465815.
RA Nonami A., Kato R., Taniguchi K., Yoshiga D., Taketomi T., Fukuyama S., Harada M., Sasaki A., Yoshimura A.
RT Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.
RL J. Biol. Chem. 279:52543-52551 (2004).
RN [41]; RE0068438.
RX PUBMED: 16966486.
RA Samardzija M., Wenzel A., Aufenberg S., Thiersch M., Reme C., Grimm C.
RT Differential role of Jak-STAT signaling in retinal degenerations.
RL FASEB J. 20:2411-2413 (2006).
RN [42]; RE0069067.
RX PUBMED: 15630138.
RA Inoue H., Kato R., Fukuyama S., Nonami A., Taniguchi K., Matsumoto K., Nakano T., Tsuda M., Matsumura M., Kubo M., Ishikawa F., Moon B. G., Takatsu K., Nakanishi Y., Yoshimura A.
RT Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.
RL J. Exp. Med. 201:73-82 (2005).
RN [43]; RE0069210.
RX PUBMED: 8592940.
RA Lowe C., Gillespie G. A., Pike J. W.
RT Leukemia inhibitory factor as a mediator of JAK/STAT activation in murine osteoblasts.
RL J. Bone Miner. Res. 10:1644-1650 (1995).
RN [44]; RE0069503.
RX PUBMED: 20974963.
RA Rochman Y., Kashyap M., Robinson G. W., Sakamoto K., Gomez-Rodriguez J., Wagner K. U., Leonard W. J.
RT Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
RL Proc. Natl. Acad. Sci. USA 107:19455-19460 (2010).
RN [45]; RE0070879.
RX PUBMED: 9582023.
RA Chaturvedi P., Reddy M. V., Reddy E. P.
RT Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation.
RL Oncogene 16:1749-1758 (1998).
RN [46]; RE0023424.
RX PUBMED: 8943308.
RA Sawyer S. T., Penta K.
RT Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction.
RL J. Biol. Chem. 271:32430-32437 (1996).
RN [47]; RE0023523.
RX PUBMED: 10545526.
RA Bousquet C., Susini C., Melmed S.
RT Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor.
RL J. Clin. Invest. 104:1277-1285 (1999).
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