AC T00311
XX
ID T00311
XX
DT 26.01.1993 (created); hse.
DT 20.08.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA GATA-3-isoform1
XX
SY GATA-3; GATA-box binding factor 3; GATA3; NF-E1c (chick).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003927 GATA3; HGNC: GATA3.
XX
CL C0004; CC; 2.2.1.1.3.1.
XX
SZ 443 AA; 47.9 kDa (cDNA) (calc.).
XX
SQ MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV
SQ PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT
SQ SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE
SQ KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL
SQ GGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL
SQ IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEG
SQ IQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT
SQ PMHPPSSLSFGPHHPSSMVTAMG
XX
FT 30 74 
essential for trans-activation [7].
FT 249 311 
essential for nuclear translocation [7].
FT 257 307 
SM00401; ZnF_GATA.
FT 257 311 
PS50114; GATA_ZN_FINGER_2.
FT 263 297 
PF00320; GATA zinc finger.
FT 303 348 
essential for DNA-binding [7].
FT 311 361 
SM00401; ZnF_GATA.
FT 311 364 
PS50114; GATA_ZN_FINGER_2.
FT 317 351 
PF00320; GATA zinc finger.
XX
SF 2 zinc finger motifs;
XX
CP T lymphocytes [3] [12]; neuroblastoma cell lines; eosinophils and basophils [11] [11] [12] [3].
EX blood,neutrophil granulocyte,,adult; none; RT-PCR; total RNA; [11].
XX
FF ectopic expression can rescue erythroid differentiation of GATA-1 T00305 deficient murine embryonic stem cells [10];
FF transcription factor, look up the TRANSFAC cross reference for more details;
FF a dominant negative mutant of GATA-3-isoform1 (mutation of KRR to AAA at position 304-306) blocks transactivation by GATA-1, -2 and -3 in co-transfection experiments [9];
XX
MX M00077 V$GATA3_01.
MX M00350 V$GATA3_02.
MX M00351 V$GATA3_03.
MX M01878 V$GATA3_Q4.
MX M00203 V$GATA_C.
MX M00789 V$GATA_Q6.
XX
BS R02158.
BS R04901.
BS R08143.
BS R08144.
BS R08145.
BS R08146.
BS R08147.
BS R08148.
BS R08265.
BS R14554.
BS R00590.
BS R03268.
BS R14574.
BS R14575.
BS R14576.
BS R14538.
BS R14541.
BS R14542.
BS R02795.
BS R03723.
BS R01432.
BS R00507.
BS R14566.
BS R14572.
BS R14573.
BS R08270.
BS R08271.
BS R08272.
BS R08276.
XX
DR TRANSPATH: MO000005568.
DR TRANSCOMPEL: C00026.
DR TRANSCOMPEL: C00088.
DR SMARTDB: SB000096.
DR EMBL: M69106;
DR EMBL: X55037;
DR EMBL: X55122;
DR EMBL: X58072;
DR UniProtKB: P23771-1;
XX
RN [1]; RE0000167.
RX PUBMED: 2225071.
RA Orkin S. H.
RT Globin gene regulation and switching: Circa 1990
RL Cell 63:665-672 (1990).
RN [2]; RE0000451.
RX PUBMED: 1827068.
RA Ho I.-C., Vorhees P., Marin N., Oakley B. K., Tsai S.-F., Orkin S. H., Leiden J. M.
RT Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene
RL EMBO J. 10:1187-1192 (1991).
RN [3]; RE0000452.
RX PUBMED: 2050118.
RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei M.-G., Romeo P.-H.
RT A t-cell specific TCR delta DNA binding protein is a member of the human GATA family
RL EMBO J. 10:1809-1816 (1991).
RN [4]; RE0001473.
RX PUBMED: 2017177.
RA Ko L. J., Yamamoto M., Leonard M. W., George K. M., Ting P., Engel J. D.
RT Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer
RL Mol. Cell. Biol. 11:2778-2784 (1991).
RN [5]; RE0002546.
RX PUBMED: 1871134.
RA Marine J., Winoto A.
RT The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elemets
RL Proc. Natl. Acad. Sci. USA 88:7284-7288 (1991).
RN [6]; RE0002959.
RX PUBMED: 8321207.
RA Merika M., Orkin S. H.
RT DNA-binding specificity of GATA family transcription factors
RL Mol. Cell. Biol. 13:3999-4010 (1993).
RN [7]; RE0007082.
RX PUBMED: 8114750.
RA Yang Z., Gu L., Romeo P.-H., Bories D., Motohashi H., Yamamoto M., Engel J. D.
RT Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains
RL Mol. Cell. Biol. 14:2201-2212 (1994).
RN [8]; RE0011089.
RX PUBMED: 7556215.
RA Joulin V., Richard-Foy H.
RT A new approach to isolate genomic control regions, Application to the GATA transcription factor family
RL Eur. J. Biochem. 232:620-626 (1995).
RN [9]; RE0011693.
RX PUBMED: 7829479.
RA Smith V. M., Lee P. P., Szychowski S., Winoto A.
RT GATA-3 dominant negative mutant. Functional redundancy of the T cell receptor alpha and beta enhancers.
RL J. Biol. Chem. 270:1515-1520 (1995).
RN [10]; RE0013446.
RX PUBMED: 7823931.
RA Blobel G. A., Simon M. C., Orkin S. H.
RT Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins.
RL Mol. Cell. Biol. 15:626-633 (1995).
RN [11]; RE0013448.
RX PUBMED: 8507862.
RA Zon L. I., Yamaguchi Y., Yee K., Albee E. A., Kimura A., Bennett J. C., Orkin S. H., Ackerman S. J.
RT Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.
RL Blood 81:3234-3241 (1993).
RN [12]; RE0013453.
RX PUBMED: 8386664.
RA Biassoni R., Verdiani S., Cambiaggi A., Romeo P.-H., Ferrini S., Moretta L.
RT Human CD3-CD16+ natural killer cells express the hGATA-3 T cell transcription factor and an unrearranged 2.3-kb TcR delta transcript.
RL Eur. J. Immunol. 23:1083-1087 (1993).
RN [13]; RE0023899.
RX PUBMED: 11937547.
RA Kieffer L. J., Greally J. M., Landres I., Nag S., Nakajima Y., Kohwi-Shigematsu T., Kavathas P. B.
RT Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3
RL J. Immunol. 168:3915-3922 (2002).
RN [14]; RE0013452.
RX PUBMED: 1370462.
RA Dorfman D. M., Wilson D. B., Bruns G. A. P., Orkin S. H.
RT Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.
RL J. Biol. Chem. 267:1279-1285 (1992).
XX
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